Midcareer K24 Award for Mentoring and Patient-Oriented Research

职业生涯中期 K24 指导和以患者为导向的研究奖

基本信息

批准号：
10618740
负责人：
PHILLIP O COFFIN
金额：
$ 20.25万
依托单位：
SAN FRANCISCO DEPARTMENT OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-01 至 2028-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10618740
关键词：
Absence of pain sensation Acceleration Affect Animals Behavior Therapy Benefits and Risks Caring Characteristics Cocaine Data Data Set Development Disease Ecological momentary assessment Elderly Enrollment Event Failure Female Funding Gender HIV Healthcare Systems Heroin Hour Human Intervention Interview Longitudinal cohort study Mental Health Mentors Methamphetamine Methamphetamine overdose Mid-Career Clinical Scientist Award (K24)Modeling Morbidity - disease rate Motivation Naloxone National Institute of Drug Abuse Neuropathy Opioid Opioid Analgesics Overdose Pain Pain Nature Pain Research Pain intensity Pain management Palliative Care Participant Patients Peripheral Nervous System Diseases Persons Pharmaceutical Preparations Poisoning Postoperative Period Primary Care Qualitative Methods Reading Reporting Research Research Personnel Rewards Risk San Francisco Science Self Care Self Management Social isolation Source Stimulant Time Toxic effect Training Voice career chronic pain chronic pain patient clinical practice cohort experience experimental study faculty mentor implementation science improved methamphetamine effect methamphetamine use mortality non-cancer chronic pain novel novel strategies opioid use overdose death painful neuropathy patient oriented patient oriented research pharmacologic pleasure poor health outcome prescription opioid reduced substance use response social stimulant use substance use suicide mortality transmission process trial design viral transmission

项目摘要

Project Summary/Abstract This K24 award will support the candidate’s development as a mentor and substance use investigator, while completing a novel study of the use of non-prescribed stimulants in the self-care of chronic pain, particularly among people living with HIV and neuropathic pain. The candidate will complete training in mentoring through differentness to further enhance his ability to mentor trainees underrepresented in science, while also developing and delivering a training targeted for mentors not underrepresented, in order to improve the pipeline of senior mentors who can effectively mentor underrepresented trainees. He will also enhance his abilities to conduct substance use research by obtaining additional training in implementation science, ecological momentary assessment, adaptive trial design, and pain research. He will undertake directed reading with experts in pain research and in mentoring. In addition, the candidate will pursue new research to examine the phenomenon of non-prescribed stimulant use self-care of chronic pain. The candidate will enroll 50 people living with HIV and neuropathic pain who report methamphetamine use for pain self-care for 6 months of ecological momentary assessments, to determine the relationship between use and functional pain. The candidate will conduct qualitative interviews with 30 of the participants to explore the nature of the pain and relationship between physical and social pain, as well as the perceived risks and benefits to methamphetamine use. Finally, he will compare those who do not use stimulants, who use stimulants for pain, and who use stimulants for other reasons from his longitudinal cohort study of patients with chronic pain to establish longitudinal effects of methamphetamine use for pain self-care.

项目概要/摘要该 K24 奖项将支持候选人作为导师和药物使用调查员的发展，同时完成一项关于使用非处方兴奋剂自我护理慢性疼痛的新颖研究，特别是候选人将通过指导完成艾滋病毒感染者和神经性疼痛患者的培训。差异性，以进一步提高他指导科学领域代表性不足的学员的能力，同时也制定并提供针对代表性不足的导师的培训，以提高能够有效指导代表性不足的学员的高级导师的管道也将增强他的能力。通过获得实施科学方面的额外培训来进行药物滥用研究的能力，他将进行生态瞬时评估、适应性试验设计和疼痛研究。此外，候选人还将进行新的研究来检验。非处方兴奋剂使用自我护理慢性疼痛的现象将招收50人。患有艾滋病毒和神经性疼痛的人报告使用甲基苯丙胺进行疼痛自我护理 6 个月生态瞬时评估，以确定使用和功能性疼痛之间的关系。候选人将与 30 名参与者进行定性访谈，以探讨疼痛的本质和身体和社会痛苦之间的关系，以及甲基苯丙胺的感知风险和益处最后，他会比较那些不使用兴奋剂、使用兴奋剂缓解疼痛的人和使用兴奋剂的人。其他原因的兴奋剂来自他对慢性疼痛患者的纵向队列研究来建立甲基苯丙胺用于疼痛自我护理的纵向影响。