Midcareer K24 Award for Mentoring and Patient-Oriented Research

职业生涯中期 K24 指导和以患者为导向的研究奖

• 批准号: 10618740
• 负责人: PHILLIP O COFFIN
• 金额: $ 20.25万
• 依托单位: SAN FRANCISCO DEPARTMENT OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10618740
• 关键词: Absence of pain sensation; Acceleration; Affect; Animals; Behavior Therapy; Benefits and Risks; Caring; Characteristics; Cocaine; Data; Data Set; Development; Disease; Ecological momentary assessment; Elderly; Enrollment; Event; Failure; Female; Funding; Gender; HIV; Healthcare Systems; Heroin; Hour; Human; Intervention; Interview; Longitudinal cohort study; Mental Health; Mentors; Methamphetamine; Methamphetamine overdose; Mid-Career Clinical Scientist Award (K24); Modeling; Morbidity - disease rate; Motivation; Naloxone; National Institute of Drug Abuse; Neuropathy; Opioid; Opioid Analgesics; Overdose; Pain; Pain Nature; Pain Research; Pain intensity; Pain management; Palliative Care; Participant; Patients; Peripheral Nervous System Diseases; Persons; Pharmaceutical Preparations; Poisoning; Postoperative Period; Primary Care; Qualitative Methods; Reading; Reporting; Research; Research Personnel; Rewards; Risk; San Francisco; Science; Self Care; Self Management; Social isolation; Source; Stimulant; Time; Toxic effect; Training; Voice; career; chronic pain; chronic pain patient; clinical practice; cohort; experience; experimental study; faculty mentor; implementation science; improved; methamphetamine effect; methamphetamine use; mortality; non-cancer chronic pain; novel; novel strategies; opioid use; overdose death; painful neuropathy; patient oriented; patient oriented research; pharmacologic; pleasure; poor health outcome; prescription opioid; reduced substance use; response; social; stimulant use; substance use; suicide mortality; transmission process; trial design; viral transmission

Project Summary/Abstract This K24 award will support the candidate’s development as a mentor and substance use investigator, while completing a novel study of the use of non-prescribed stimulants in the self-care of chronic pain, particularly among people living with HIV and neuropathic pain. The candidate will complete training in mentoring through differentness to further enhance his ability to mentor trainees underrepresented in science, while also developing and delivering a training targeted for mentors not underrepresented, in order to improve the pipeline of senior mentors who can effectively mentor underrepresented trainees. He will also enhance his abilities to conduct substance use research by obtaining additional training in implementation science, ecological momentary assessment, adaptive trial design, and pain research. He will undertake directed reading with experts in pain research and in mentoring. In addition, the candidate will pursue new research to examine the phenomenon of non-prescribed stimulant use self-care of chronic pain. The candidate will enroll 50 people living with HIV and neuropathic pain who report methamphetamine use for pain self-care for 6 months of ecological momentary assessments, to determine the relationship between use and functional pain. The candidate will conduct qualitative interviews with 30 of the participants to explore the nature of the pain and relationship between physical and social pain, as well as the perceived risks and benefits to methamphetamine use. Finally, he will compare those who do not use stimulants, who use stimulants for pain, and who use stimulants for other reasons from his longitudinal cohort study of patients with chronic pain to establish longitudinal effects of methamphetamine use for pain self-care.

项目摘要/摘要 该K24奖将支持候选人作为精神和药物使用调查员的发展，而 完成一项关于在慢性疼痛的自我护理中使用非处方刺激剂的新研究，尤其是 在患有艾滋病毒和神经性疼痛的人中。候选人将通过 不同之处，以进一步增强他在科学领域的精神培训能力不足的能力，同时也 为了改善未代表性的导师，开发和提供针对导师的培训 高级导师的管道有效地代表人数不足。他还将增强他的 通过获得实施科学方面的额外培训来进行药物使用研究的能力， 生态瞬时评估，适应性试验设计和疼痛研究。他将进行定向阅读 具有疼痛研究和心理研究专家。此外，候选人将进行新的研究以进行考试 非处方刺激物的现象使用了慢性疼痛的自我保健。候选人将注册50人 患有艾滋病毒和神经性疼痛的人报告甲基苯丙胺用于疼痛自我护理6个月 生态瞬间评估，以确定使用与功能疼痛之间的关系。 候选人将对30名参与者进行定性访谈，以探索疼痛的性质和 身体和社会痛苦之间的关系，以及甲基苯丙胺的风险和益处 使用。最后，他将比较那些不使用兴奋剂，使用兴奋剂痛苦并使用的人 由于他的纵向队列研究的其他原因，刺激因素是慢性疼痛患者的 甲基苯丙胺用于疼痛自我护理的纵向作用。