2022 Angiotensin GRC/GRS

2022 血管紧张素 GRC/GRS

• 批准号: 10381797
• 负责人: Minolfa C Prieto
• 金额: $ 4万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-23 至 2022-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10381797
• 关键词: 2019-nCoV; ACE2; Academia; Address; Adipose tissue; Aging; Angiotensin I; Angiotensin II; Angiotensin Receptor; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Anniversary; Area; Award; Basic Science; Biology; Blood Pressure; Bone Marrow; COVID-19; COVID-19 pandemic; Cardiometabolic Disease; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Clinic; Clinical; Clinical Medicine; Clinical Sciences; Collaborations; Data; Development; Diabetes Mellitus; Digestive System Disorders; Disease; Doctor of Medicine; Doctor of Philosophy; Electrolyte Balance; Electrolytes; Endocrine System Diseases; Enzymes; Etiology; Event; Fostering; Funding; Future; Gender; Generations; Goals; Health; Health Sciences; Hematological Disease; Homeostasis; Human Biology; Hypertension; Immune response; Immune system; Industry; Inflammatory Response; Institutes; International; Joints; Kidney; Kidney Diseases; Lead; Leadership; Life Cycle Stages; Liquid substance; Mediator of activation protein; Medical Research; Mentors; Mentorship; Metabolic Diseases; Minority Groups; Mission; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Disease; National Institute of Diabetes and Digestive and Kidney Diseases; Neurocognition; Neurosecretory Systems; Nutrition Disorders; Obesity; Organ; Outcome; Oxidative Stress; Pathologic Processes; Pathology; Persons; Pharmacogenomics; Population; Postdoctoral Fellow; Productivity; Proteins; Proteomics; Public Health; Quality of life; Regulation; Renin-Angiotensin-Aldosterone System; Research; Research Personnel; Research Training; Role; SARS-CoV-2 infection; Science; Scientist; Sex Differences; System; Therapeutic; Tissues; Translating; Translational Research; Travel; Underrepresented Minority; Underrepresented Populations; United Kingdom; United States National Institutes of Health; Universities; Urologic Diseases; Virginia; Woman; Women Physicians; angiotensin I (1-7); arm; base; career; career development; design; fetal programming; frontier; graduate student; human disease; improved; insight; liver function; meetings; metabolomics; minority student; nephrogenesis; novel; precision medicine; programs; receptor; receptor function; success; symposium; systems research; therapeutic target; tool; undergraduate student

PROJECT SUMMARY The renin angiotensin aldosterone system (RAAS) is a key regulator of cardiovascular (CV) function, fluid electrolyte balance, and homeostasis, and it influences many systems including the renal, neuroendocrine, and immune systems. Perturbations of the RAAS trigger a cascade of events, including generation of vasoactive mediators, oxidative stress, inflammatory responses, and tissue remodeling, thus contributing to end-organ pathology and disease. In the 2022 GRC on Ang, we will discuss the most recent, cutting-edge discoveries in the field and share insights on emerging new areas beyond the CV system such as the role of the RAAS in adipose biology, bone marrow regulation, liver function, neurocognition, and immune responses. The conference will focus on the latest advances of the RAAS from discovery science to clinical impact. A highlight in 2022 will be the celebration of 22 years of the discovery of ACE2. ACE2 is a multifunctional protein, that not only is CV protective by generating Ang-(1-7) and Ang-(1-9) from Ang II and Ang I respectively, but it is also, tissue injurious by acting as the receptor for the SARS-CoV-2, the etiologic agent of the current worldwide COVID-19 pandemic. The enigmas of ACE2 as a key enzyme in the protective arm of the RAAS will be a highlight. The role of ACE2 as a major mediator and potential therapeutic target in COVID-19 will be debated along with the controversies on the progression of COVID-19 infection and long-term outcomes in populations treated with ACE inhibitors and/or angiotensin receptor blockers. The 2022 GRC on Ang will further feature novel topics including sex-differences in the regulation and changes of the RAAS during the life course (fetal programming, kidney development, and aging) will be further addressed. In line with precision medicine being the next frontier in clinical medicine, the meeting will also highlight new advances in the pharmacogenomics, proteomics, and metabolomics of the RAAS in human diseases. Preceding the GRC, we will have the 2022 Gordon Research Seminar (GRS), a special forum for graduate students, postdoctoral fellows, early career researchers and other junior scientists to present and exchange new data and cutting-edge ideas. The 2022 GRS will focus on recent advances in RAAS studies beyond the classical paradigms, including new functions of receptors from this system and providing trainees with an enhanced understanding of current tools to aid their research, and cover a wide range of topics including the immune system, sex differences and aging. Additionally, the mentorship sessions will address the interplay between academia and industry and discuss approaches to translate scientific discoveries to the clinic and how to optimize impact. The aims are aligned with the NHLBI, NIDDK and NIAID missions and initiative and the scientific themes that will be covered are of direct relevance to these institutes. NIH funds requested will help attract young investigators and trainees, including from underrepresented groups with limited opportunities to joint top national and international experts in the RAAS for networking among researchers, clinicians, young investigators and trainees.

项目概要 肾素血管紧张素醛固酮系统 (RAAS) 是心血管 (CV) 功能、体液的关键调节因子。 电解质平衡和体内平衡，它影响许多系统，包括肾脏、神经内分泌和 免疫系统。 RAAS 的扰动会引发一系列事件，包括血管活性物质的产生 介质、氧化应激、炎症反应和组织重塑，从而有助于终末器官 病理学和疾病。在 Ang 的 2022 年 GRC 中，我们将讨论 Ang 领域的最新、前沿发现 领域并分享对简历系统之外新兴领域的见解，例如 RAAS 在 脂肪生物学、骨髓调节、肝功能、神经认知和免疫反应。这 会议将重点关注 RAAS 从发现科学到临床影响的最新进展。一个亮点 2022 年将庆祝 ACE2 发现 22 周年。 ACE2是一种多功能蛋白质， 仅通过分别从 Ang II 和 Ang I 生成 Ang-(1-7) 和 Ang-(1-9) 来保护 CV，但它也是， 作为 SARS-CoV-2 的受体，造成组织损伤，SARS-CoV-2 是当前全球范围内流行的病原体 2019冠状病毒病大流行。 ACE2 作为 RAAS 保护臂中的关键酶，其谜团将是 强调。 ACE2 作为 COVID-19 主要介质和潜在治疗靶点的作用将受到争论 以及关于 COVID-19 感染进展和人群长期结果的争议 用ACE抑制剂和/或血管紧张素受体阻滞剂治疗。 2022 年 Ang 上的 GRC 将进一步呈现 新颖的主题包括生命过程中 RAAS 调节和变化的性别差异（胎儿 编程、肾脏发育和衰老）将得到进一步解决。符合精准医疗 临床医学的下一个前沿，会议还将重点介绍药物基因组学的新进展， 人类疾病中 RAAS 的蛋白质组学和代谢组学。在 GRC 之前，我们将举办 2022 年 戈登研究研讨会（GRS），针对研究生、博士后研究员、早期职业生涯的特别论坛 研究人员和其他初级科学家展示和交流新数据和前沿思想。 2022年 GRS 将重点关注 RAAS 研究超越经典范式的最新进展，包括新功能 该系统的受体，并让学员更好地了解当前的工具来帮助 他们的研究涵盖了广泛的主题，包括免疫系统、性别差异和衰老。 此外，指导会议将讨论学术界和工业界之间的相互作用，并讨论 将科学发现转化为临床的方法以及如何优化影响。目标是一致的 NHLBI、NIDDK 和 NIAID 的使命和倡议以及将涵盖的科学主题是 与这些机构有直接关系。 NIH 请求的资金将有助于吸引年轻的研究人员和实习生， 包括来自代表性不足的群体，与顶级国家和国际专家联合的机会有限 在 RAAS 中，用于研究人员、临床医生、年轻研究人员和实习生之间的联系。