Early joint cranial and brain development from fetal and pediatric imaging

胎儿和儿科成像的早期关节颅骨和大脑发育

• 批准号: 10456319
• 负责人: Natasha Lepore
• 金额: $ 68.81万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10456319
• 关键词: 3-Dimensional; Accounting; Address; Affect; Age; Ants; Arizona; Birth; Bone Development; Brain; Brodmann' s area; Cephalic; Child; Childhood; Clinical; Clinical Management; Cognition; Colorado; Craniosynostosis; Data; Data Set; Databases; Deformity; Development; Diagnosis; Diffusion; Disease; Evolution; Face; Fetal Development; Fetal Growth; Fetus; Funding; Future; Goals; Growth; Head; Health; Hospitals; Image; Imaging Device; Imaging Techniques; Impaired cognition; Individual; Infant; Institution; Intracranial Hypertension; Joints; Knowledge; Live Birth; Logistic Regressions; Los Angeles; Magnetic Resonance Imaging; Manuals; Measures; Methodology; Methods; Modeling; Morphology; Motion; Motor; Multiple Pregnancy; National Institute of Child Health and Human Development; National Institute of Dental and Craniofacial Research; Neurologic; Organ; Patients; Pediatric Hospitals; Physicians; Positioning Attribute; Pregnancy; Research; Research Personnel; Resources; Sampling; Shapes; Standardization; Surgical sutures; Syndrome; System; Testing; Thick; Time; Universities; Variant; Work; X-Ray Computed Tomography; aged; automated segmentation; base; bone; brain abnormalities; brain morphology; brain shape; brain tissue; brain volume; cortex mapping; cranium; design; developmental disease; disability; early childhood; fetal; graphical user interface; imaging modality; improved; improved outcome; in utero; in vivo; indexing; model development; morphometry; multidisciplinary; programs; quantitative imaging; sex; success; tool; treatment planning; user-friendly

PROJECT SUMMARY The devastating impacts of early-childhood cranial and skull deformities affect nearly 25% of infants from single pregnancies and 50% of those from multiple pregnancies. If not diagnosed early and treated effectively, these abnormalities can impact brain development, leading to cognitive impairment, elevated intracranial pressure, and motor disabilities. Clinicians’ capacity to effectively diagnose and treat these disorders is hindered by two things: first, a limited understanding of how the cranium and brain normally grow and co- develop; and, second, a dearth of imaging techniques that are sensitive enough to analyze joint cranial and brain development in both healthy and abnormal instances. To address these limitations, a strong, interdisciplinary, collaborative team from Children’s National Hospital, Children’s Hospital Los Angeles, Brown University, University of Colorado and Arizona State University proposes the current R01 aimed at developing the first normative joint model of brain and cranium development before and after birth. This work is f ueled by the team’s robust prior efforts, in which they independently collected large, normative datasets of computed tomography (CT) and magnetic resonance (MR) images of infants and fetuses, and implemented preliminary tools to analyze them as a starting point for new methods to be developed as part of this project . The team’s hypothesis is that the development of regional cortical and cranial morphologies will be strongly associated. It will be tested using the following aims: (1) Develop quantitative imaging tools to model healthy cranial development in infants; (2) Determine the joint development of cranial and cortical shape and thickness in infants; (3) Develop a preliminary model of fetal brain and cranial growth across gestation; and (4) Build and disseminate a user-friendly toolbox for clinicians and researchers. This project will be the first systematic in-vivo study of joint healthy cranial and brain development before and after birth. As such, it will determine typical variations of the cranial shape and their correlations with brain parameters, adjusted for age and sex. The normative models generated here will serve as clinical resources for matched comparisons in individual children with suspected disorders that involve abnormal cranial shapes. Additionally, precise in-vivo quantitative imaging methods for assessing joint cranial and brain shape in inf ants will be developed in this project and will serve as invaluable tools for physicians to better assess, diagnose, and plan treatment for infant cranial deformities in the future.

项目概要 儿童早期颅骨和头骨畸形的破坏性影响影响了近 25% 的婴儿 单胎妊娠和 50% 的多胎妊娠如果未及早诊断和有效治疗， 这些异常会影响大脑发育，导致认知障碍、颅内压升高 压力和运动障碍是临床医生有效诊断和治疗这些疾病的能力。 受到两件事的阻碍：首先，对颅骨和大脑如何正常生长和协作的了解有限。 其次，缺乏足够灵敏的成像技术来分析关节颅骨和 为了解决这些限制，需要强大的、 来自国家儿童医院、洛杉矶儿童医院、布朗的跨学科协作团队 大学、科罗拉多大学和亚利桑那州立大学提出当前的 R01 旨在开发 出生前后大脑和颅骨发育的第一个规范联合模型是这项工作的推动者。 该团队之前的努力，他们独立收集了计算的大型规范数据集 婴儿和胎儿的断层扫描（CT）和磁共振（MR）图像，并进行了初步 分析它们的工具作为该团队开发新方法的起点。 假设是区域皮质和颅骨形态的发育密切相关。 将使用以下目标进行测试：（1）开发定量成像工具来模拟健康颅骨 (2) 确定颅骨和皮质的形状和厚度的联合发育 婴儿；(3) 开发妊娠期胎儿大脑和颅骨生长的初步模型； 为追随者和研究人员传播用户友好的工具箱。 该项目将是之前第一个针对关节健康颅骨和大脑发育的系统体内研究 因此，它将确定出生后颅骨形状的典型变化及其与大脑的相关性。 此处生成的规范模型将作为临床资源。 对患有涉及异常颅骨形状的疑似疾病的个别儿童进行匹配比较。 此外，用于评估婴儿蚂蚁的关节颅骨和大脑形状的精确体内定量成像方法 将在该项目中开发，并将作为医生更好地评估、诊断、 并计划未来婴儿颅骨畸形的治疗。