LOCALIZATION OF CEREBRAL DYSFUNCTION IN DEMENTIA (AD)

痴呆症 (AD) 脑功能障碍的定位

• 批准号: 3417300
• 负责人: MALCOLM COOPER
• 金额: $ 31.03万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 1994-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3417300
• 关键词: Alzheimer's disease; blood flow measurement; cognition; cognition disorders; computer simulation; dementia; human subject; magnetic resonance imaging; memory; neuroanatomy; neurophysiology; pathologic process; positron emission tomography; short term memory; verbal learning

The broad objective of the proposed research is to advance currently available neuro-imaging techniques in order to facilitate their application to disorders characterized by cognitive and behavioral dysfunction. The specific aims of this proposal are to improve image analysis methods for integrating anatomical MR images and functional PET images of regional cerebral blood flow obtained by using H215O and apply behavioral/physiological techniques to generate cognitive signals that are valuable in understanding localized dysfunction in demented patients. There are three major components in the development of image analysis methods: (1) Image registration: Improved methods based on surface- fitting techniques will be developed for spatially registering a set of MR images with a series of PET emission images that are acquired by injecting H215O to the same subject under different behavioral/physiological conditions; (2) Image interpolation: Accurate interpolation schemes for both the shapes of the brain surface and the intensity levels of brain images will be developed using an dynamic elastic force field model to generate more complete 3-D brain image data sets; and (3) Image subtraction: New techniques will be developed for detecting, localizing, and enhancing the cognitive signals by subtracting PET images at a baseline state from images at a stimulus state. The detected cognitive signals will be also be in registration with the anatomical map provided by MR images. In developing behavioral/physiological techniques, three procedures will be used to generate cognitively induced signals for understanding localized dysfunction in demented patients: (1) Modified Sternberg procedure, in which signals related to short-term memory will be assessed; (2) Serial reaction time procedure, in which signals related to implicit memory will be evaluated; and (3) Verbal comprehension procedure, which will be employed to enhance global cerebral flow. The results of this research will be of value in determining the neuronal systems affected in the dementia of Alzheimer's disease and related degenerative disorders and contribute to an improved understanding of the pathophysiological mechanisms involved in the degenerative processes.

拟议研究的广泛目标是目前促进 可用的神经成像技术，以便于他们 应用于以认知和行为为特征的疾病 功能障碍。 该提议的具体目的是改善形象 整合解剖学MR图像和功能性PET的分析方法 使用H215O获得的区域脑血流图像并应用 行为/生理技术生成认知信号 在理解痴呆症中的局部功能障碍方面很有价值 患者。 图像分析的开发中有三个主要组成部分 方法：（1）图像注册：基于表面的改进方法 将开发拟合技术，用于空间注册一组 具有一系列宠物排放图像的MR图像由 将H215O注入不同的主题 行为/生理状况； （2）图像插值：准确 大脑表面形状的插值方案和 大脑图像的强度水平将通过动态发展开发 弹性力场模型生成更完整的3D脑图像数据 套; （3）图像减法：将开发新技术 检测，本地化和增强认知信号 从刺激处的图像中减去基线状态下的宠物图像 状态。 检测到的认知信号也将是注册 使用MR图像提供的解剖图。 在开发行为/生理技术时，将三个程序 用于生成认知感应的信号以理解 痴呆患者的局部功能障碍：（1）修饰的Sternberg 过程，其中与短期内存有关的信号是 评估； （2）串行反应时间过程，其中信号相关 将评估隐式记忆； （3）言语理解 该程序将用于增强全球脑流。 这项研究的结果将在确定 在阿尔茨海默氏病和 相关的退化性疾病，并有助于改善 了解参与的病理生理机制 退化过程。