RADIATION EFFECTS ON TITANIUM IMPLANT OSSEOINTEGRATION

辐射对钛种植体骨整合的影响

• 批准号: 3425316
• 负责人: GLENN E MINSLEY
• 金额: $ 2.17万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1989-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3425316
• 关键词: angiogenesis; biomaterial compatibility; dogs; endosseous dental implant; necrosis; radiation therapy; radiobiology; thrombosis; titanium

Osseointegrated dental implants are being used in prosthetic reconstruction for maxillofacial prosthetic patients (patients who have sustained the loss of oral or facial anatomy due to trauma, congenital anomaly or oncological disease) to aid in the retention of intraoral and facial prostheses. These implants combined with a mechanical attachment (i.e. magnets, clip-bar) embedded in the prosthesis provided a superior, more predictable result in retention of prostheses as compared to other retentive methods (i.e. adhesives). Many of these patients with oncological disease receive radiation therapy. Typically, patients who have received radiotherapy have not undergone implant treatment. This is due to a lack of research determining the predictability of osseointegration in irradiated bone. The purpose of this study is to provide needed preliminary information to asess the effects upon osseointegration when these implants are placed into previously irradiated bone. The specific aims of the project are to evaluate qualitatively and quantitatively and new bone formation around the implants and surrounding areas six months following implantation in irradiated bone in a suitable animal model. This implantation will be performed after a healing period of six months has elapsed following exposure of the bony site to a prescribed fractionated course of radiation therapy. In addition, qualitative and quantitative evaluations will be made for the presence of any other bone formation (i.e. necrotic bone), fibroplasia and vascular changes (i.e. thrombosis, angiogenesis). The significance of the study will be to provide prelimunary information regarding feasible and predictable outcomes for clinical use of this implant system in prosthetic reconstruction for humans who have undergone radiotherapy. Six young adult mongrel dogs will be used for this study. The dogs will be randomly divided into two equal groups. Each group will receive a different dose of radiation given in a fractionated regiment (30Gy and 60Gy respectively). The proposed protocol will involve radiotherapy to the zygomatic arch and occipital crest on one side of the dog's head. The opposing side will be protected from and radiation. This side will serve as a control. After a six month rest period following the completion of radiotherapy, implants will be placed into both the irradiated and control sides. After a six month healing period, the implants will be recovered for analysis following euthanasia of the animals. The results from this study will serve to direct future long-term investigations in this area.

骨整合牙种植体被用于修复 颌面修复患者的重建（患者 由于外伤导致口腔或面部解剖结构丧失， 先天性异常或肿瘤疾病）以帮助保留 口腔内和面部假体。 这些植入物结合 嵌入的机械附件（即磁铁、夹杆） 假肢提供了更好、更可预测的结果 与其他固位方法相比，假体的固位 （即粘合剂）。 其中许多患者患有肿瘤疾病 接受放射治疗。 通常，接受过治疗的患者 未曾接受放射治疗或种植治疗。 这是由于 缺乏确定可预测性的研究 辐照骨中的骨整合。 本研究的目的是 提供评估效果所需的初步信息 当这些种植体被植入骨整合时 之前受过辐射的骨头。 该项目的具体目标是 定性和定量评估新骨 植入物周围和周围区域六个月后形成 植入合适动物的受辐射骨骼后 模型。 这种植入将在愈合期后进行 骨部位暴露于某种物质后六个月过去了 规定分次放射治疗疗程。 此外， 将进行定性和定量评估 存在任何其他骨形成（即坏死骨）， 纤维增生和血管变化（即血栓形成、血管生成）。 该研究的意义在于提供初步的 有关可行和可预测结果的信息 该种植体系统在假体重建中的临床应用 接受过放射治疗的人。 六名青年 这项研究将使用杂种狗。 狗们将会 随机分为相等的两组。 每组将获得一份 分次治疗中给予不同剂量的放射（30Gy 和 60Gy）。 拟议的协议将涉及 一侧颧弓和枕嵴放射治疗 狗的头。 对方将受到保护，免受和 辐射。 此侧将作为控制。 六个月后 完成放射治疗、植入后的休息时间 将被放置在照射侧和对照侧。 经过一个 六个月的愈合期，种植体将恢复 动物安乐死后的分析。 结果来自 这项研究将有助于指导未来的长期调查 这个区域。