GORDON RES CONF--ENZYMES AND METABOLIC PATHWAYS

GORDON RES CONF——酶和代谢途径

• 批准号: 3435017
• 负责人: WILLIAM J RAY
• 金额: $ 0.4万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1989-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3435017
• 关键词: X ray crystallography; cofactor; enzyme mechanism; enzyme structure; enzymes; meeting /conference /symposium; protein folding; site directed mutagenesis; travel

Support is requested for the Gordon Research Conference on Enzymes, Coenzymes and Metabolic Pathways that will be held at the Kimball Union Academy, Meriden, New Hampshire from July 4 through July 8, 1988. The emphasis of this conference is on enzymes: their structure, the relationship of their structure to chemical catalysis, the coenzymes and prosthetic groups involved in their reactions, binding interactions of substrates, inhibitors and effectors, and the pathways which metabolically contiguous enzymes control in biological systems, together with their regulation. Among other topics, the 1988 conference will include discussions on the use of site-directed mutagenesis, X-ray crystallography, and possibly transferred Nuclear Overhauser enhancement, in defining catalytic mechanism and binding interactions; chemical catalysis, both in enzymic and nonenzymic systems; the structural basis for protein folding and stability; the design of enzymes with altered structure/function/stability, nucleic acid enzymology, and mechanisms of metabolic control.

要求在戈登研究会议上支持 酶，辅酶和代谢途径将保持在 新罕布什尔州梅里登（Meriden）的金博尔联盟学院（Kimball Union Academy） 4至1988年7月8日。这次会议的重点是 酶：它们的结构，结构与 化学催化，辅酶和假体涉及 在其反应中，底物，抑制剂的结合相互作用 和效应子，以及代谢连续的途径 酶在生物系统中控制及其 规定。 除其他主题外，1988年的会议将包括 讨论使用位置定向诱变，X射线的讨论 晶体学，并可能转移核透射器 增强，定义催化机制和结合 互动；化学催化，包括酶和非酶 系统；蛋白质折叠和稳定性的结构基础；这 具有改变结构/功能/稳定性的酶的设计， 核酸酶学和代谢控制的机制。