SYMPOSIUM ON RISK ASSESSMENT OF NASAL CARCINOGENS

鼻腔致癌物风险评估研讨会

• 批准号: 3434796
• 负责人: MAARTEN C BOSLAND
• 金额: $ 0.7万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1989-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3434796
• 关键词: Rodentias; aldehydes; bioassay; carcinogenesis; chemical carcinogen; chemical related neoplasm /cancer; disease /disorder model; disease /disorder proneness /risk; dust; environment related neoplasm /cancer; formaldehyde; nickel; nose neoplasm; toxicology

The purpose of this international conference is to bring together scientists involved in regulatory, applied, and fundamental toxicology to discuss the relevance for human health of nasal tumors found in rodent bioassays. Formaldehyde is only one of several compounds capable of producing nasal tumors in rodents. ln recent NTP bioassays the nasal mucosa was the fourth most important site of carcinogenesis, after liver, kidney and mammary gland. The interaction of scientists that this conference aims at is intended to yield a better understanding of the pathobiological and environmental factors involved in nasal carcinogenesis in rodents, leading to some guidance for establishing the carcinogenic potential and assessing the health risk for man of chemicals that cause nasal tumors in rodents. Additional goals is to update the knowledge about chemical-environmental factors related to nasal tumors in man, such as aldehydes, nickel and wood dust. The current status of what is understood about the mechanisms of nasal carcinogenesis will be discussed in depth. Finally regulation of nasal carcinogens in differents countries will be discussed. ln addition, it is intended to draft recommendations for research needed to enhance our capability to judge the relevance for human health of exposure to such chemicals. Senior investigators and regulatory scientists in the field will be invited as speakers, discussants and session chairpersons. The participation of junior investigators will be encouraged by making available a limited number of travel stipends and creating the possibility for the presentation of recent results relevant to the conference topic. The proceedings, including full papers by the speakers, as well as a report on the various discussions, will be published promptly.

这次国际会议的目的是结合在一起 参与监管，应用和基本的科学家 毒理学讨论与鼻部人类健康的相关性 在啮齿动物生物测定中发现的肿瘤。 甲醛只是之一 几种能够在啮齿动物中产生鼻肿瘤的化合物。 LN最近的NTP生物测定鼻粘膜是第四的 癌症发生的重要部位，肝脏，肾脏和乳腺后 腺。 这次会议旨在的科学家的互动 旨在更好地理解病理学 和鼻癌中涉及的环境因素 啮齿动物，导致一些建立致癌的指导 潜力并评估化学物质人的健康风险 引起啮齿动物的鼻肿瘤。 其他目标是更新 关于与鼻部有关的化学环境因素的知识 人类的肿瘤，例如醛，镍和木尘。 这 有关鼻腔机制的理解的现状 致癌作用将在深入讨论。 最终调节 将讨论不同国家 /地区的鼻癌。 Ln 此外，它旨在起草研究建议 需要增强我们判断与人类相关性的能力 暴露于此类化学物质的健康。 高级调查人员和 该领域的监管科学家将被邀请作为演讲者， 讨论者和会议主席。 大三的参与 通过使调查人员有限 旅行津贴的数量，并创造了可能性 与会议主题相关的最新结果的介绍。 诉讼程序，包括演讲者的完整论文，以及 有关各种讨论的报告将及时发表。