Validity and Utility of a PATCH to Monitor Free-living Energy Expenditure in Children 3 to 8 Years Old

监测 3 至 8 岁儿童自由生活能量消耗的补丁的有效性和实用性

• 批准号: 10353453
• 负责人: Bridget R. Armstrong
• 金额: $ 21.62万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10353453
• 关键词: 8 year old; Acceleration; Accelerometer; Age; Assessment tool; Behavior; Cardiovascular Diseases; Caring; Chest; Child; Child Health; Complex; Data; Development; Device Designs; Devices; Diabetes Mellitus; Electrocardiogram; Energy Metabolism; Epidemiology; Equation; Evaluation; Goals; Health; Heart Rate; Hour; Human body; Indirect Calorimetry; Individual; Intervention; Intervention Studies; Laboratories; Link; Longevity; Maintenance; Measurement; Measures; Methodology; Methods; Mind; Monitor; Movement; Nature; Obesity; Observational Study; Outcome; Phase; Photoplethysmography; Physical activity; Physical assessment; Polysomnography; Postage Stamps; Prevention; Protocols documentation; Research; Resistance; Series; Signal Transduction; Skin; Sleep; Technology; Testing; Time; Water; acceptability and feasibility; base; design; energy balance; epidemiology study; fitbit; free behavior; improved; innovation; novel; open source; sedentary; sensor; validation studies; wearable device

Accurate assessment of physical activity energy expenditure is essential to (1) quantify the relationships between energy expenditure and children’s health outcomes and (2) assess intervention/prevention effects. However, energy expenditure is difficult to assess in free-living conditions. A combination of heart rate (HR) and accelerometry data provides a more precise estimate of energy expenditure than either HR or accelerometry alone, when compared to a criterion measure of direct or indirect calorimetry. However, very few available devices exist which capture both HR and accelerometry. Although some scientific- grade (e.g., ActiHeart) and consumer-grade wearable devices (e.g., Fitbit) incorporate multiple sensors (i.e. accelerometry and HR via chest leads or photoplethysmography), restrictions to raw signal data (FitBit) or the need to change chest leads daily (ActiHeart) makes it problematic to use such devices to measure energy expenditure in children. Moreover, these devices were not developed with children in mind, and therefore, have limitations regarding size, comfort, and the need for daily care/maintenance. The current study leverages microcontroller wearable electronics’ technology to develop a small device that adheres to the human body (referred to here as the ‘PATCH’). The PATCH is the size of a postage stamp and incorporates multiple sensors (i.e. accelerometry and photoplethysmography) in a single device. Using multiple channels of raw signal data, we can more accurately estimate energy expenditure under free-living conditions. The PATCH is far less obtrusive than existing scientific grade integrated devices (i.e., ActiHeart) or commercial wearable devices (i.e., FitBit), and thus has the potential to improve acceptability and wear-time, particularly among children. Our long-term goal is to advance the measurement field for epidemiologic- and intervention- based studies that focus on measuring 24-hour movement and energy expenditure. The objectives of the proposed project are to conduct a series of studies that include both laboratory and field- based protocols to establish the preliminary reliability, validity and utility/feasibility of the new PATCH technology for measuring children’s energy expenditure in free-living conditions. We will evaluate the validity of the PATCH to measure physical activity and HR of children (age 3-8 years old) compared to criterion measures of accelerometry and electrocardiography, respectively. We will develop equations to predict energy expenditure and examine initial concordance compared to indirect calorimetry. Using quantitative and qualitative methodology, we will also assess the feasibility and acceptability of wearing the PATCH over extended periods of monitoring wear time (e.g., 30 days). This technology has the potential to become a research standard for intervention and epidemiological studies of energy expenditure among children. Results from the current study will inform the next phase of development for wearable devices to measure the energy expenditure of free-living individuals.

准确评估身体活动能量消耗对于 (1) 量化之间的关系至关重要 能量消耗和儿童健康结果；(2) 评估干预/预防效果。 在自由生活条件下很难评估心率 (HR) 和能量消耗的组合。 加速度测量数据比 HR 或加速度测量提供更精确的能量消耗估计 与直接或间接量热法的标准测量相比。 然而，能够同时采集心率和加速度测量数据的可用设备非常少。 级（例如 ActiHeart）和消费级可穿戴设备（例如 Fitbit）包含多个传感器（即 通过胸导联或光电体积描记法进行加速度测量和心率测量）、对原始信号数据的限制 (FitBit) 或 需要每天更换胸导联（ActiHeart）使得使用此类设备测量能量存在问题 此外，这些设备的开发并未考虑到儿童，因此， 尺寸、舒适度和日常护理/维护需求方面的限制。 当前的研究利用微控制器可穿戴电子技术来开发一种小型设备 粘附在人体上（此处称为“PATCH”）。 PATCH 的大小与邮票相同，并且 在单个设备中集成多个传感器（即加速度测量法和光电体积描记法）。 通过原始信号数据通道，我们可以更准确地估计自由生活条件下的能量消耗。 PATCH 远不如现有的科学级集成设备（即 ActiHeart）或商业设备那么引人注目。 可穿戴设备（即 FitBit），因此有可能提高可接受性和佩戴时间，特别是 我们的长期目标是推进流行病学和干预措施的测量领域。 基于专注于测量 24 小时运动和能量消耗的研究。 拟议项目的目标是进行一系列研究，包括实验室和现场研究 基于协议来建立新 PATCH 技术的初步可靠性、有效性和实用性/可行性 我们将评估 PATCH 的有效性。 测量儿童（3-8 岁）的体力活动和心率，与标准测量值进行比较 我们将分别建立加速度计和心电图来预测能量消耗。 并使用定量和定性检查与间接量热法相比的初始一致性。 方法上，我们还将评估长期佩戴 PATCH 的可行性和可接受性 监测佩戴时间（例如 30 天）的技术有潜力成为研究标准。 儿童能量消耗的干预和流行病学研究当前研究的结果。 将为可穿戴设备的下一阶段开发提供信息，以测量自由生活的能量消耗 个人。