CELLULAR AGING AND OXYGEN FREE RADICALS

细胞老化和氧自由基

• 批准号: 3118850
• 负责人: RAJINDAR S SOHAL
• 金额: $ 11.83万
• 依托单位: SOUTHERN METHODIST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3118850
• 关键词: Insecta; aging; animal tissue; cell age; cell senescence; electron transport; free radical oxygen; genetic strain; longevity; mitochondria; oxidoreductase; species difference; superoxide dismutase; superoxides

The ultimate goal of the prospective studies is to understand the nature of the mechanisms underlying the aging process in animals. The objective of the proposed studies is to test the predictions of the free radical hypothesis of aging. The relationship between rates of oxy-radical generation and aging will be explored by pursuing three different lives of investigation: (1) Determine if rates of O2 and H2O2 generation by mitochondria increase during aging in mammalian and insect species. (2) Determine if rates of O2 and H2O2 generation by mitochondria are correlated with variations in life span of different mammalian and insect species. Comparisons will be made within rather than between the phylogenetic groups. (3) Investigate why the rates of O2 and H2O2 generation by mitochondria vary in different tissues and species. Results of this study will promote a better understanding of the relationship between oxy-radical and hydroperoxide production by mitochondria and the aging process.

前瞻性研究的最终目标是了解 动物衰老过程的基础机制。 目的 拟议的研究是测试自由基的预测 衰老的假设。 氧基速率之间的关系 通过追求三种不同的生活，将探索产生和衰老 调查：（1）确定O2和H2O2的速率是否通过 哺乳动物和昆虫物种衰老期间的线粒体增加。 （2） 确定线粒体生成的O2和H2O2的速率是否相关 不同的哺乳动物和昆虫物种的寿命变化。 比较将在系统发育之间而不是在内部进行 组。 （3）调查为什么O2和H2O2的速率通过 线粒体在不同的组织和物种中有所不同。 这项研究的结果将促进对 氧基 - 自由基与氢过氧化物之间的关系通过 线粒体和衰老过程。