Science and Engineering for Sensors, Mechanisms, and Biomarkers of Exposures

传感器、机制和暴露生物标志物的科学与工程

• 批准号: 9259573
• 负责人: JOHN M ESSIGMANN
• 金额: $ 125.9万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9259573
• 关键词: Active Listening; Address; Adolescent; Advocacy; Affect; Age; Air; Alkylating Agents; Animals; Area; Aromatic Polycyclic Hydrocarbons; Authorship; Benzo(a)pyrene; Biochemical; Biological; Biological Markers; Biology; Biomedical Engineering; Boston; Carbon; Carbon Nanotubes; Carcinogens; Cellular Phone; Chemical Engineering; Chemistry; Chemoprotective Agent; Communication; Communication Programs; Communities; Community Outreach; Complex; Consensus; Data; Development; Dimethylnitrosamine; Disease; Educational process of instructing; Engineering; Environment; Environmental Engineering technology; Environmental Health; Environmental Pollution; Evaluation; Exposure to; Faculty; Genetic; Genomic Instability; Health; Human; Immigrant; Induced Mutation; Industrialization; Information Systems; Institutes; Interdisciplinary Study; Light; Liquid substance; Location; Low income; Maine; Malignant Neoplasms; Maps; Massachusetts; Mathematics; Measurable; Mission; Modeling; Molecular; Mutation; N-nitrosodimethylamine; National Institute of Environmental Health Sciences; Native Americans; Nitrosamines; Pattern; Physics; Planet Earth; Poison; Policies; Population; Positioning Attribute; Postdoctoral Fellow; Predisposition; Public Health; Research; Research Personnel; Risk; Risk Estimate; Rivers; Science; Scientist; Signal Recognition Particle; Societies; Source; Structure; Superfund; System; Systems Biology; Technology; Training; Training Activity; Training Programs; Translations; Ursidae Family; Water; Work; atmospheric chemistry; base; carcinogenicity; cost; disease registry; disorder risk; environmental agent; environmental justice; exposure route; feeding; functional group; gene environment interaction; graduate student; innovation; mature animal; member; multidisciplinary; next generation; novel; novel marker; phosphoproteomics; programs; remediation; response; sensor; superfund site; tool; training opportunity; transcriptomics; tribal leader; tumor; undergraduate student; waste treatment; willingness

Overall: Project Summary/Abstract Native Americans in Maine, and people living in the Mystic River Watershed in Massachusetts have expressed serious concerns about contaminants in their environments. In both locations, people are negatively impacted by legacy contaminants, and in both cases, there are Environmental Justice communities of concern. The Loring Air Force Base Superfund site impacts the Native Americans, and the Industri-Plex, Wells G&H, and Olin Superfund sites impact people living in the Mystic River Watershed (a land area north and east of Boston, covering 76 square miles that drains into rivers feeding into the Boston Harbor). The MIT-SRP brings engineering and scientific innovation to bear on critical problems relevant to our stakeholders in Maine and Massachusetts. Our problem-oriented program centers around two pervasive contaminants, N-nitrosamines (potently carcinogenic to animals) and PAHs (carcinogenic to people). Both of these contaminants are broadly important as they are present in multiple Superfund sites and they continue to be produced by ongoing industrial activities today. The MIT-SRP with its diverse expertise (from engineers, to chemists, to biologists and to biological engineers) has the tools, the commitment, and the willingness to collaborate, making it possible to take on these serious environmental health challenges. Specifically, the MIT-SRP will: a) identify novel PAH breakdown products; b) develop novel sensor technologies including a low cost smartphone- enabled carbon nanotube sensor; c) use high fidelity duplex consensus sequencing to reveal patterns of mutations that can be traced to specific contaminants; d) reveal how age and stage of development impact susceptibility to N-nitrosodimethylamine and PAH-induced mutations and cancer; e) reveal how gene- environment interactions impact susceptibility to genomic instability and cancer; and f) use phosphoproteomics and transcriptomics to uncover systems-level molecular responses that shed light on underlying mechanisms of disease and give rise to novel biomarkers of disease risk. These tools will inform policy, enable risk estimates, and guide remediation. Our bi-directional program is based on established relationships with local agencies that represent our stakeholders. To maximize the impact of our Program, we will continue to grow our relationships with the Massachusetts Department of Public Health, the ATSDR, the EPA, the NIEHS and Tribal Leaders. Embedded in all of the MIT-SRP activities are training opportunities for undergraduates, graduate students and postdocs, thus supporting the next generation of environmental health scientists. The impact of the MIT-SRP is predicted to be significant, thanks to multidisciplinary collaboration among engineers, biomedical researchers, community outreach professionals, and experts in training and translation. Further, the technologies and approaches that will be developed can be broadly disseminated among Superfund sites and elsewhere. Taken together, the MIT-SRP will enable reduced risk, guidance for remediation, and support for policy decisions, thus having a direct and measurable impact on public health.

总体而言：项目摘要/摘要 缅因州的美洲原住民和马萨诸塞州神秘河流域的居民表示 严重关注其环境中的污染物。在这两个地方，人们都受到了负面影响 遗留污染物，在这两种情况下，都有环境正义社区关注。这 洛林空军基地超级基金网站影响了美洲原住民、Industri-Plex、Wells G&H 和 奥林超级基金站点影响居住在神秘河流域（波士顿北部和东部的土地区域， 占地 76 平方英里，流入河流，注入波士顿港）。 MIT-SRP 带来 工程和科学创新，以解决与缅因州和缅因州利益相关者相关的关键问题 马萨诸塞州。我们以问题为导向的计划围绕两种普遍存在的污染物：N-亚硝胺 （对动物有强致癌性）和多环芳烃（对人有致癌性）。这两种污染物广泛 很重要，因为它们存在于多个超级基金站点中，并且它们继续由正在进行的 今天的工业活动。 MIT-SRP 拥有多元化的专业知识（从工程师、化学家到生物学家） 对于生物工程师来说）拥有工具、承诺和合作意愿，使其成为可能 有可能应对这些严峻的环境健康挑战。具体来说，MIT-SRP 将： a) 确定 新颖的PAH分解产品； b）开发新颖的传感器技术，包括低成本智能手机- 启用碳纳米管传感器； c) 使用高保真双工一致性测序来揭示模式 可追溯到特定污染物的突变； d) 揭示年龄和发育阶段如何影响 对 N-亚硝基二甲胺和 PAH 诱导的突变和癌症的易感性； e) 揭示基因如何- 环境相互作用影响基因组不稳定性和癌症的易感性； f) 使用磷酸蛋白质组学 和转录组学来揭示系统级分子反应，从而揭示潜在机制 疾病并产生疾病风险的新生物标志物。这些工具将为政策提供信息，促进风险 评估并指导整改。我们的双向计划基于与当地建立的关系 代表我们利益相关者的机构。为了最大限度地发挥我们计划的影响，我们将继续发展 我们与马萨诸塞州公共卫生部、ATSDR、EPA、NIEHS 和 部落首领。 MIT-SRP 的所有活动中都包含为本科生提供的培训机会， 研究生和博士后，从而支持下一代环境健康科学家。这 由于工程师之间的多学科合作，预计 MIT-SRP 的影响将是巨大的， 生物医学研究人员、社区外展专业人员以及培训和翻译专家。更远， 将开发的技术和方法可以在超级基金站点之间广泛传播 和其他地方。总而言之，MIT-SRP 将能够降低风险、提供补救指导并提供支持 政策决策，从而对公共卫生产生直接和可衡量的影响。