CEREBROVASCULAR TIME RESOLVED CONTRAST ENHANCED 3D MRA

脑血管时间分辨对比增强 3D MRA

• 批准号: 2031197
• 负责人: PATRICK Alan TURSKI
• 金额: $ 16.76万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-05 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2031197
• 关键词: angiography; artery stenosis; cardiovascular imaging /visualization; carotid artery; clinical research; human subject; magnetic resonance imaging; method development

DESCRIPTION (Adapted from Applicant's Abstract): Accurate measurement of proximal internal carotid artery stenosis requires clear delineation of the residual lumen within the stenotic segment. We have recently developed a technique for gadolinium enhanced 3D time resolved magnetic resonance arteriography that can accomplish this goal. The technique provides a series of 3D images with sufficient temporal resolution to separate the carotid arteries from the jugular veins. The availability of the temporal image series avoids uncertainties in injection timing relative to image acquisition and permits image subtraction in a manner completely analogous to DSA but with 3D reprojection capabilities. Subtraction of accumulated background signal from previous injection allows for multiple site studies with repeated injections. We hypothesize that with images available at all points in the contrast pass, including the peak, small doses of contrast material with permit examination of the aortic arch, cervical vessels and intracranial vessels. Specific aims include: (1) implementation of a data acquisition scheme in which a subset of each 3D data set is used to form an on-line 2D subtracted projection image which will permit selection of a subset of the entire 3D data set to be chosen for reconstruction. (2) Use of ROI data from the preview images to permit reweighting of acquired k-space volumes to reduce intra and extraluminal artifacts. (3) Investigation of temporal and spatial resolution for image of the carotid bifurcation. (4) Optimization of the dose of intravenous contrast material and the injection rate. (5) Implementation of these innovation for a blinded assessment of carotid stenosis measurement.

描述（根据申请人的摘要改编）：准确测量 颈内动脉狭窄近端需要明确描述 狭窄段内的残留管腔。 我们最近开发了 Gadolinium增强3D时间解析的磁共振的技术 可以实现这一目标的动脉造影。 该技术提供了 一系列具有足够时间分辨率的3D图像 颈静脉的颈动脉。 时间的可用性 图像系列避免了相对于图像的注射时间不确定性 以完全类似的方式获取和允许图像减法 到DSA，但具有3D再投影功能。 累积的减法 先前注射的背景信号允许进行多次站点研究 重复注射。 我们假设这是完全可用的图像 对比度中的点，包括峰值，小剂量的对比度 允许检查主动脉弓，宫颈血管和 颅内血管。 具体目的包括：（1）实施数据 采集方案，其中每个3D数据集的子集用于形成一个 在线2D减去投影图像，该图像将允许选择 整个3D数据集的子集用于重建。 （2）使用 从预览图像中的ROI数据允许重新加权 K空间量减少内部和外部伪影。 （3） 研究颈动脉图像的时间和空间分辨率 分叉。 （4）优化静脉对比材料的剂量 和注射率。 （5）实施这些创新 颈动脉狭窄测量的盲评估。