Research Training Center for Botanicals and Chronic Diseases in Tajikistan and Indonesia

塔吉克斯坦和印度尼西亚植物药和慢性病研究培训中心

• 批准号: 10878049
• 负责人: ILYA RASKIN
• 金额: $ 25.6万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-28 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10878049
• 关键词: Biodiversity; Biomedical Research; Botanicals; Cardiovascular Diseases; Cementation; Central Asia; Chronic Disease; Collaborations; Community Outreach; Country; Degree requirements; Diabetes Mellitus; Distance Learning; Educational Curriculum; Educational workshop; Ensure; Event; Faculty; Foundations; Funding; Grant; Health; Health Professional; Indonesia; Inflammation; Institution; Interdisciplinary Study; International; Intestinal Diseases; Laboratories; Louisiana; Mentors; Metabolic; Metabolic syndrome; Minority-Serving Institution; Monitor; Pharmacologic Substance; Postdoctoral Fellow; Prevention; Research Training; Resources; Rheumatoid Arthritis; Scientist; Students; Tajikistan; Teacher Professional Development; Testing; Training; Training Programs; Training and Infrastructure; United States National Institutes of Health; Universities; Visit; combat; common treatment; community college; doctoral student; evidence base; experience; nervous system disorder; online course; programs; resilience; symposium; synergism

This renewal will build on a successful research training program carried out in Tajikistan during the last five years. We will leverage accumulated expertise, training materials, networks of international collaborators, and well-developed and tested online and face-to-face training curricula to expand the Tajikistan program and to add Indonesia to the program. Close collaborations between US, Tajik and Indonesian faculty involved in this proposal are well-established and fully functional. The expanded Center for Botanicals and Chronic Diseases (CBCD) will cement and synergize these existing collaborations and provide quality international experience for our trainees. In the next five years, CBCD will focus its training on the evidence-based, rigorous studies of local botanicals for the prevention and treatment of common inflammation-associated chronic diseases and disorders, such as diabetes and metabolic syndrome, cardiovascular diseases, osteo- and rheumatoid arthritis, and intestinal and neurological disorders. CBCD will train 10 scientists in Tajikistan (5 Ph.D. students and 5 postdoctoral fellows) and 24 scientists in Indonesia (16 M.S. and 8 Ph.D. students). Both countries are providing a significant financial match to enable the training. Research training components will include: 1) Online courses and e-workshops; 2) One-on-one e- mentoring and progress monitoring; 3) Annual in-country conferences and workshops with invited international speakers; 4) Visits to mentor's laboratories in the US (funded by Tajikistan for Tajik students); and 5) Required graduate and postdoctoral courses offered in partnering countries. CBCD will involve three U.S. institutions - Rutgers University, Pennington Biomedical Research Center/Louisiana State University, and Eugenio María de Hostos Community College (CUNY), a minority serving institution specializing in health-related training. Internationally, CBCD will involve three leading Tajik institutions and two top-tier Indonesian universities. In addition to its official trainees, CBCD will open its distance learning courses, on-line training and in-country events to a wider audience of local scientists and health professionals, ensuring a broader community outreach. CBCD’s aim is to provide a sustainable foundation for intense research training and retention of local scientists in the interdisciplinary studies of botanicals for the prevention and treatment of chronic diseases. Our integrated training program will leverage resources generated through other NIH-funded programs that involve the research training faculty participating in this proposal: NIH National Center for Botanicals and Metabolic Resiliency (2004 – present); NIH T32 Training Grant in Botanical Approaches to Combat Metabolic Syndrome (just renewed for a 5 year third cycle) and the completed International Cooperative Biodiversity Groups (ICBG) program titled “Building New Pharmaceutical Capabilities in Central Asia.” CBCD will also take advantage of the world-wide research training infrastructure established by the Global Institute for Bioexploration (GIBEX).

这种更新将在最后一个成功的研究培训计划基础上在塔吉克斯坦进行 五年。我们将利用积累的专业知识，培训材料，国际合作者的网络， 并经过精心开发和测试在线和面对面培训课程，以扩展塔吉克斯坦计划和 为该计划添加印度尼西亚。我们之间的密切合作，塔吉克和印尼教师参与了这一点 提案已建立良好且功能齐全。扩展的植物和慢性疾病中心 （CBCD）将巩固并协同这些现有合作，并为 我们的学员。在接下来的五年中，CBCD将把培训重点放在基于证据的，严格的本地研究上 预防和治疗常见感染相关的慢性疾病和疾病的植物学， 例如糖尿病和代谢综合征，心血管疾病，骨和类风湿关节炎以及 肠道和神经系统疾病。 CBCD将在塔吉克斯坦培训10位科学家（5个博士学位和5名博士后研究员）和24位科学家 在印度尼西亚（16 M.S.和8 Ph.D.学生）。两国都提供了一项重大的财务匹配，以实现 培训。研究培训组件将包括：1）在线课程和电子工作坊； 2）一对一的E- 心理和进步监测； 3）与受邀国际的年度国内会议和研讨会 演讲者； 4）参观美国的导师实验室（由塔吉克斯坦为塔吉克学生资助）； 5）需要 合作国家提供的研究生和博士后课程。 CBCD将涉及三个美国机构 - 罗格斯大学，彭宁顿生物医学研究 中心/路易斯安那州立大学和EugenioMaríaDeHostos社区学院（CUNY），少数派服务 专门从事与健康有关的培训的机构。在国际上，CBCD将涉及三个领先的塔吉克机构 和两所顶级印尼大学。除了其官方学员外，CBCD还将开放其远程学习 向众多当地科学家和卫生专业人员的众多听众的课程，在线培训和国内活动， 确保更广泛的社区宣传。 CBCD的目的是为深入研究培训和保留本地的可持续基础提供可持续的基础 植物学跨学科研究的科学家，用于预防和治疗慢性疾病。我们的 集成培训计划将利用其他NIH资助计划产生的资源，涉及 参与该建议的研究培训教师：NIH国家植物与代谢中心 弹性（2004 - 现在）； NIH T32培训补助金用于战斗代谢综合症的植物学方法 （刚刚续签了5年的第三个周期）和完整的国际合作生物多样性小组（ICBG） 计划“在中亚建立新的药物能力”。 CBCD也将利用 全球生物探索研究所（Gibex）建立的全球研究培训基础设施。

项目成果

Hypolipidemic effect of brown seaweed (Sargassum crassifolium) extract in vivo (Study of histopathology, mRNA expression, and immunohistochemistry (IHC) with VCAM-1, ICAM-1, and MCP-1 parameters).

褐海藻（Sargassum crassifolium）提取物的体内降血脂作用（组织病理学、mRNA 表达和使用 VCAM-1、ICAM-1 和 MCP-1 参数的免疫组织化学 (IHC) 研究）。

• 发表时间: 2024
• 期刊: ArXiv
• 作者: Zaidan,Sarah;Abdillah,Syamsudin;Arfian,Nur;Arozal,Wawaimuli
• 通讯作者: Arozal,Wawaimuli

POLYPHENOLS CONTENT AND ANTIOXIDANT ACTIVITY OF ARTEMISIA SIEVERSIANA WILLD. IN WESTERN PAMIR.

大叶蒿的多酚含量和抗氧化活性。

• 发表时间: 2017
• 期刊: American scientific journal
• 作者: Miravalova,Gulazor;Kurbonbekova,Shifo;Satorov,Shukratdzhon;Mirzorahimov,Akobir;Navruzshoev,Dovudsho;Dushenkov,Vyacheslav;Vakhidova,Manizha
• 通讯作者: Vakhidova,Manizha