Tailored Retention and Engagement for Equitable Treatment of OUD and Pain (TREETOP)

为公平对待 OUD 和疼痛而量身定制的保留和参与 (TREETOP)

• 批准号: 10876692
• 负责人: Megan Hamm
• 金额: $ 274.2万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10876692
• 关键词: Tailored; Retention; Engagement; Equitable; Treatment

PROJECT SUMMARY/ABSTRACT: The Tailored Retention and Engagement for Equitable Treatment of OUD and Pain (TREETOP) clinical research center at the University of Pittsburgh (Pitt) is part of the NIH IMPOWR network. TREETOP draws on the NIDA Clinical Trials Network Appalachian (Pennsylvania & West Virginia) and Western States (Oregon) Nodes and the Community-based OUD and Pain Enhanced treatment (COPE) collaborative (Baltimore, Maryland) to develop effective, equitable, and sustainable interventions for chronic pain and OUD. Our overall goal is to improve treatment for comorbid chronic pain and OUD across the OUD Treatment Cascade, prioritizing two disproportionately impacted communities for whom equitable implementation of effective interventions can be challenging: rural and Black communities. We will achieve our overall goal through the integrated contributions of 5 center components as follows: 1) Research Site Overview, Management, and Operations - Our diverse multidisciplinary team has extensive experience with multisite clinical trials as well as in TREETOP’s two emphasis areas, health equity and implementation science. 2) Engagement and Outreach - Our TREETOP Stakeholder Consultation Board (SCB) includes representatives with a variety of perspectives and lived experiences from each clinic and community partnering in our studies and will serve as active participants on the research team. 3) Engagement/Retention Research Projects - Both projects share the central premise that treating chronic pain improves pain and OUD outcomes, tailor a pain self-management (PSM) intervention to patients with co-morbid chronic pain and OUD, and evaluate both the intervention effectiveness and the barriers and facilitators to equitable and sustained implementation of the intervention through the Health Equity Implementation Framework. Specifically, the Engagement research project investigates whether PSM can improve pain and engage primary care patients in medication treatment for OUD, while the Retention project investigates whether PSM and/or flexibly dosed buprenorphine/naloxone can improve pain and retention in treatment among patients who have already initiated care in office-based addiction treatment programs. 4) Data Collection, Management, and Harmonization - The Data Core will be led by investigators with a track record of success in the measurement and analysis of patient-reported outcomes and in leading clinical trials and data coordinating centers, and includes national leaders in the PROMIS Health Organization. 5) Pilot Projects - Our Pilot program includes 3 initial studies on pain measurement, chronic pain/OUD treatment implementation in specialty settings, and chronic pain and OUD stigma, and then follows a standard protocol for soliciting and reviewing future pilot projects addressing health equity and implementation science. Overall Impact: Our TREETOP investigators and SCB will collaborate to advance the science of sustainably and equitably managing chronic pain and OUD, prioritizing disproportionately impacted rural and Black communities.

项目摘要/摘要：量身定制的保留和参与，以公平治疗OUD 匹兹堡大学（PITT）的疼痛（Treetop）临床研究中心是NIH Impowr的一部分 网络。 Treetop借鉴了NIDA临床试验网络阿巴拉契亚（宾夕法尼亚州和西弗吉尼亚州） 以及西方国家（俄勒冈州）节点以及基于社区的Oud和疼痛增强治疗（COPE） 合作（马里兰州巴尔的摩）为慢性开发有效，公平和可持续的干预措施 痛苦和乌德。我们的总体目标是改善合并症慢性疼痛的治疗 治疗级联，优先考虑两个不成比例的受影响的社区 实施有效的干预措施可能会受到挑战：粗糙和黑人社区。我们将实现我们的 通过5个中心组件的综合贡献进行的总体目标如下：1）研究站点 概述，管理和运营 - 我们的潜水员多学科团队在 多站点临床试验以及Treetop的两个强调领域，健康平等和实施 科学。 2）参与和外展 - 我们的树梢利益相关者咨询委员会（SCB）包括 代表每个诊所和社区合作的各种观点和生活经验 在我们的研究中，将担任研究团队的活跃参与者。 3）参与/保留研究 项目 - 两个项目都有一个主要的前提，即治疗慢性疼痛会改善疼痛和OUD 结局，对慢性慢性疼痛和OUD患者的疼痛自我管理（PSM）量身定制干预， 并评估干预效率以及公平和持续的障碍和促进者 通过健康公平实施框架实施干预措施。具体来说， 参与研究项目调查PSM是否可以改善疼痛并吸引初级保健患者 在OUD的药物治疗中，保留项目调查了PSM和/或灵活服用 丁丙诺啡/纳洛酮可以改善已经 在基于办公室的成瘾治疗计划中开始护理。 4）数据收集，管理和 协调 - 数据核心将由研究人员领导，并在测量中取得成功的记录 以及对患者报告的结果以及领先的临床试验和数据协调中心的分析以及 包括Promis保健组织中的国家领导人。 5）试点项目 - 我们的试点计划包括3 有关疼痛测量，慢性疼痛/OUD治疗实施的初步研究以及 慢性疼痛和污名 针对健康公平和实施科学的项目。总体影响：我们的树梢调查员 SCB将合作发展可持续和同样管理慢性疼痛和OUD的科学， 优先考虑对农村和黑人社区的不成比例。