TB/MDR-TB Research training and Capacity Strengthening for LMIC in Southeast Asia Phase II: End-of-Fiscal-Year Supplement

东南亚中低收入国家结核病/耐多药结核病研究培训和能力强化第二阶段：财年末补充文件

• 批准号: 10877205
• 负责人: Angkana Chaiprasert
• 金额: $ 4.92万
• 依托单位: PRINCE OF SONGKLA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10877205
• 关键词: Affect; Big Data; Collaborations; Contact Tracing; Country; Data; Databases; Disease; Epidemiologist; Epidemiology; Evaluation; Goals; Grant; Health system; Human Resources; Indonesia; Institution; Interruption; Investments; Manuscripts; Mentors; Methods; Mission; Multidrug-Resistant Tuberculosis; Myanmar; Mycobacterium tuberculosis; Peer Review; Phase; Policies; Politics; Postdoctoral Fellow; Prevalence; Procedures; Publications; Research; Research Personnel; Research Project Grants; Research Proposals; Research Training; Resources; Scientist; Series; Southeastern Asia; Supervision; Surveys; Thailand; Training; Tuberculosis; Universities; Work; Writing; genome sequencing; global health; improved; low and middle-income countries; member; post-doctoral training; professor; programs; research facility; responsible research conduct; screening; senior faculty; whole genome

Project Summary/Abstract TB/MDR-TB is a serious global health problem. Southeast Asia is a region heavily affected by this disease. To achieve the END-TB goal, research on TB must be enhanced. The objective of our D43TW009522 grant "TB/MDR-TB Research capacity strengthening program for Southeast Asia, Phase II" is to strengthen TB research capacity, especially human resources for TB research, at LMIC collaborating research centers and the National TB Control Program (NTP) in Myanmar, Thailand, and Indonesia. Since 2015, we have been training a series of young researchers from these three countries effectively. The trainees were from the collaborating centers, who return to work in their countries successfully. However, there has been a serious political turmoil in Myanmar in 2021. Research facilities and human resources are interrupted. Most of our alumni could not continue to work in the country. There is a need to try different methods, including indirect approaches, to assemble human resources for research. When the political situation turns more favorable, research in the country can then regain its momentum. Two Myanmar alumni of our grant are now working at the Department of Epidemiology as postdoctoral fellows on TB research. Supporting these scientists to grow further can at least partially maintain human resources for TB research that D43TW009522 had invested. At the Department of Epidemiology, Prince of Songkla University (EPI-PSU), TB research projects are growing to serve the national and global needs. We have been working more intensively with the Division of Tuberculosis (DTB) than before. Our scope of TB research has expanded to include National Big Data on the health system, which includes TB. Thailand is going to do routine whole genome sequencing on all isolates of Mycobacterium tuberculosis. TB control has become more intensive in screening and treatment of latent TB infections. These national and institutional expansions in TB research require more well-trained epidemiologists to get involved. Well-trained TB epidemiologists are therefore needed by both Myanmar and Thailand and other countries. We are requesting the end-of-year supplement grant to support these two alumni as our postdoctoral fellows They will work with the senior and junior researchers in developing research proposals, analysis of existing data, preparing manuscripts, and writing competitive research grants. Two main research topics to be accomplished by them include post-TB study and analysis of management gap in TB contact tracing. As PSU is pushing Responsible Conduct of Research policy and practice, they will do research on join this mission. Under our supervision, they will appropriately join the National TB prevalence survey and the Project to improve the National TB database. Professor Virasakdi Chongsuvivatwong, the PI of D43TW009522, will be their main mentor and joined by the senior faculty members of EPI-PSU and Mahidol University. Annual evaluation of this post-doctoral training will follow the procedures set by PSU’s Post-doctoral Program, which emphasizes peer-reviewed scientific publication.

项目摘要/摘要 TB/MDR-TB是一个严重的全球健康问题。东南亚是一个受到严重影响的地区 疾病。为了实现结核病目标，必须增强对结核病的研究。 我们的D43TW009522的目的是“ TB/MDR-TB研究能力加强计划 东南亚，第二阶段“是为了增强结核病研究能力，尤其是结核病的人力资源 研究，LMIC合作研究中心和国家结核病控制计划（NTP） 缅甸，泰国和印度尼西亚。 自2015年以来，我们一直在有效地培训来自这三个国家的一系列年轻研究人员。 学员来自合作中心，他们成功地在自己的国家工作。 但是，缅甸在2021年发生了严重的政治动荡。研究设施和人类 资源被中断。我们的大多数校友无法继续在该国工作。有一个 需要尝试不同的方法，包括间接方法，以汇集人力资源 研究。当政治局势变得更加有利时，该国的研究就可以继续 势头。 我们赠款的两个缅甸校友现在在流行病学系作为博士后工作 TB研究的研究员。支持这些科学家进一步发展至少可以部分地维持人类 D43TW009522投资的结核病研究资源。 在桑克拉大学（Epi-PSU）流行病学系（EPI-PSU），结核病研究项目是 不断满足国家和全球需求。我们一直在与 结核病（DTB）的划分比以前。我们的结核病研究范围已扩大到包括国家 包括结核病在内的卫生系统的大数据。泰国将进行常规的整个基因组 对结核分枝杆菌的所有分离株进行测序。结核病控制已变得更加密集 筛查和治疗潜在结核病感染。这些国家和机构扩展结核病 研究要求更多训练有素的流行病学家参与其中。训练有素的结核病流行病学家是 因此，缅甸，泰国和其他国家都需要。 我们要求获得年终补充赠款，以支持这两个校友作为我们的博士后 研究员将与高级和初级研究人员合作制定研究建议，分析 现有数据，准备手稿以及撰写竞争性研究补助金。两项主要研究 他们将要完成的主题包括结核病后研究和TB接触中管理差距的分析 跟踪。由于PSU正在推动负责​​任的研究政策和实践的行为，他们将进行研究 加入这个任务。在我们的监督下，他们将适当加入国家结核病患病率调查 以及改善国家结核数据库的项目。 D43TW009522的PI Virasakdi Chongsuvivatwong教授将成为他们的主要导师，并加入 EPI-PSU和Mahidol大学的高级教职员工。 该博士后培训的年度评估将遵循PSU的博士后设定的程序 计划强调经过同行评审的科学出版物。