The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ Injury

营养在酒精引起的器官损伤的发生/进展中的作用

• 批准号: 10625843
• 负责人: CRAIG J. MCCLAIN
• 金额: $ 138.64万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625843
• 关键词: Alcohol abuse; Alcoholic Liver Diseases; Alcohols; Brain; Broccoli - dietary; Butyrates; Cause of Death; Chronic; Collaborations; Communities; Country; Development; Dietary Fats; Dietary Intervention; Education; Enhancers; Epigenetic Process; Ethanol; FDA approved; Faculty; Feces; Fetal Alcohol Spectrum Disorder; Fetal Alcohol Syndrome; Fostering; Functional disorder; Funding; Future; Goals; Grant; Health; Health Care Costs; Impairment; Individual; Industry; Injury; Institution; Interdisciplinary Study; Intervention; Intestines; Knowledge; Lactobacillus; Lipids; Mediating; Mediator; Morbidity - disease rate; National Institute on Alcohol Abuse and Alcoholism; Neural Crest Cell; Nutritional; Organ; Pathogenesis; Prevention; Prevention approach; Preventive; Probiotics; Productivity; Proteomics; Research; Research Personnel; Resources; Role; School Dentistry; Signal Transduction; Sulforaphane; Therapeutic Intervention; United States; United States National Institutes of Health; Universities; Volatile Fatty Acids; alcohol abuse therapy; alcohol exposure; alcohol intervention; alcohol research; alcohol use disorder; base; cofactor; college; exosome; gut bacteria; gut inflammation; gut-liver axis; high school; improved; intestinal barrier; liver inflammation; metabolome; metabolomics; mortality; mouse model; multidisciplinary; nanoparticle; new therapeutic target; novel; nutrition; organ injury; prevent; teratogenesis; therapeutic effectiveness; therapeutic target

The University of Louisville Alcohol Research Center (ULARC) was created to serve as a regional/national resource to perform interdisciplinary collaborative research on the role of nutrition as a cofactor in alcohol induced organ injury and as a possible therapeutic intervention to prevent/treat this organ injury. The nutrition and alcohol-induced organ injury theme of the center is unique among alcohol centers. The approach is highly translational. Our investigators include faculty from 13 departments and 6 colleges. The Specific Aims of the ULARC are to: 1) perform/facilitate interdisciplinary research on nutrition and alcohol-induced organ injury; 2) serve as a regional/national resource for the study of nutrition and alcohol-induced organ injury; 3) develop potential therapeutic targets/interventions for alcohol induced organ injury based on the mechanistic research of the ULARC; and 4) disseminate knowledge/interventions to the scientific and lay communities. We will explore interactions of nutrition and alcohol abuse in the development of alcohol-induced organ dysfunction, and we will evaluate diverse potential nutritional preventive/therapeutic interventions. Project 1 (Kirpich/McClain) evaluates the role of dietary fat in ALD pathogenesis; Project 2 (Barve) evaluates alcohol- induced epigenetic alterations in the gut:liver axis. Project 3 (Chen) will elucidate the mechanisms by which enhancers mediate ethanol-induced developmental impairment of neural crest cells and teratogenesis and unique exosome treatment for prevention of FASD. Project 4 (Feng) studies the beneficial effects of the probiotic, Lactobacillus rhamnosis GG (LGG)on the gut:liver axis in ALD. Together, these projects form a cohesive and interactive approach to investigate the effects of nutrition and nutritional interventions on alcohol-induced organ injury.

路易斯维尔大学酒精研究中心（ULARC）被创建为 区域/国家资源以营养为角色进行跨学科合作研究 酒精诱导器官损伤中的辅因子，以及可能的治疗干预措施，以防止/治疗 这种器官损伤。中心的营养和酒精引起的器官损伤主题在 酒精中心。该方法是高度转化的。我们的调查人员包括来自13个部门的教师 和6所大学。 ULARC的具体目的是： 1）对营养和酒精诱导器官损伤进行跨学科研究； 2）作为研究营养和酒精诱导器官损伤的区域/国家资源； 3）基于 ULARC的机械研究；和 4）将知识/干预传播给科学和外行社区。 我们将探索营养和酒精滥用的相互作用，以开发酒精诱导的器官 功能障碍，我们将评估各种潜在的营养预防/治疗干预措施。项目1 （Kirpich/McClain）评估饮食脂肪在ALD发病机理中的作用；项目2（Barve）评估酒精 - 肠道中诱导的表观遗传改变：肝轴。项目3（陈）将阐明该机制 增强剂介导乙醇诱导的神经rest细胞的发育障碍，致变质以及 独特的外泌体治疗以预防FASD。项目4（Feng）研究了 益生菌，肠胃疾病GG（LGG）的肠道：ALD中的肝轴。 这些项目共同构成了一种凝聚力和互动的方法，以研究营养的影响和 酒精引起的器官损伤的营养干预措施。

项目成果

Neural crest cells and fetal alcohol spectrum disorders: Mechanisms and potential targets for prevention.

神经嵴细胞和胎儿酒精谱系障碍：预防机制和潜在目标。

• DOI: 10.1016/j.phrs.2023.106855
• 发表时间: 2023-08
• 期刊: PHARMACOLOGICAL RESEARCH
• 影响因子: 9.3
• 作者: Chen, Shao-yu;Kannan, Maharajan
• 通讯作者: Kannan, Maharajan

Prevalence and Treatment for Alcohol Use Disorders Based on Kentucky Medicaid 2012-2019 Datasets.

基于肯塔基州医疗补助 2012-2019 数据集的酒精使用障碍的患病率和治疗。

• 发表时间: 2022
• 期刊: Journal of alcoholism and drug dependence
• 作者: Hu,Huirong;Mitra,Riten;Han,Yuchen;Pal,Subhadip;Huang,Haojiang;McClain,CraigJ;Vatsalya,Vatsalya;Kulasekera,KB;Kong,Maiying
• 通讯作者: Kong,Maiying

Keratin-18: Diagnostic, Prognostic, and Theragnostic for Alcohol-Associated Hepatitis.

• DOI: 10.14309/ajg.0000000000001042
• 发表时间: 2021-01-01
• 期刊: The American journal of gastroenterology
• 作者: McClain CJ;Vatsalya V;Mitchell MC
• 通讯作者: Mitchell MC

Sulforaphane Protects Against Ethanol-Induced Apoptosis in Human Neural Crest Cells Through Diminishing Ethanol-Induced Hypermethylation at the Promoters of the Genes Encoding the Inhibitor of Apoptosis Proteins.

• DOI: 10.3389/fcell.2021.622152
• 发表时间: 2021
• 期刊: Frontiers in cell and developmental biology
• 影响因子: 5.5
• 作者: Li Y;Fan H;Yuan F;Lu L;Liu J;Feng W;Zhang HG;Chen SY
• 通讯作者: Chen SY

Manipulation of MicroRNAs in Cultured Mouse Embryos: Applications for Developmental Toxicology.

• DOI: 10.1007/978-1-4939-7883-0_10
• 发表时间: 2018
• 期刊: Methods in molecular biology
• 作者: Fuqiang Yuan;Shao-yu Chen