Harvard University Center for AIDS Research

哈佛大学艾滋病研究中心

• 批准号: 10912098
• 负责人: RAJESH T GANDHI
• 金额: $ 54.55万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10912098
• 关键词: Acquired Immunodeficiency Syndrome; Address; Adolescent; Africa; Aging; Animal Model; Basic Science; Behavioral; Bioinformatics; Biometry; Boston; Clinical; Clinical Research; Collaborations; Communities; Consultations; Core Facility; Country; Dana-Farber Cancer Institute; Development; Epidemic; Epidemiology; Funding; Funding Mechanisms; General Hospitals; Generations; Goals; HIV; HIV Infections; HIV vaccine; HIV/AIDS; Health; Hospitals; Human; Immune response; Immune system; Immunity; Infection; Infrastructure; Institution; Interdisciplinary Study; International; Israel; Leadership; Link; Massachusetts; Medical center; Mentors; Mentorship; Methodology; Mission; Modeling; Molecular Virology; Mus; Pathogenesis; Patients; Pediatric Hospitals; Persons; Pilot Projects; Play; Population; Population Research; Prevention; Privatization; Process; Public Health; Public Health Schools; Reporting; Reproductive Health; Research; Research Personnel; Research Priority; Research Project Grants; Research Support; Resources; Role; Schools; Services; Site; Strategic Planning; Sum; Technology; Training and Education; Translational Research; United States National Institutes of Health; Universities; Vaccine Research; Vaccines; Woman; base; biobehavior; career; catalyst; cohort; community engagement; community science; efficacy trial; flexibility; health economics; human model; implementation science; innovation; inter-institutional; laboratory equipment; medical schools; meetings; member; multidisciplinary; next generation; programs; reproductive health of adolescents; success; synergism; vaccine candidate; working group

PROJECT SUMMARY/ABSTRACT Overall This application proposes continued funding of the Harvard University Center for AIDS Research (HU CFAR). HU CFAR is the umbrella organization for all AIDS research at Harvard, operating out of the Provost's Office. It represents each of the Harvard affiliated schools as well as the affiliated hospitals, including Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Massachusetts General Hospital, Brigham & Women's Hospital. In addition, it includes Fenway Health, extending its reach to additional clinical populations and translational research sites outside Harvard. HU CFAR builds collaborations and provides infrastructure support to coordinate and promote emerging opportunities in basic, clinical, behavioral, translational and implementation HIV research. Research emphasis among investigators includes studies of molecular virology, pathogenesis, host immune responses, epidemiology, treatment, vaccines prevention and delivery. CFAR also oversees 4 Scientific Programs (Health Economics and Modeling; HIV Vaccines; HIV Eradication) as well as 3 Scientific Working Groups (Adolescents and HIV, HIV and Aging; Reproductive Health for HIV-Infected Populations). Five core facilities have also been identified for HU CFAR support: Clinical Core, Biostatistics and Bioinformatics Core, Human Immune System Mouse, Core Advanced Laboratory Technologies Core, Bio-Behavioral and Community Science Core. In addition, an Administrative Core will provide strategic planning and fiscal oversight, and a Developmental and Mentoring Core will support innovative pilot projects related to the goals of the scientific programs and scientific working groups, and provide mentorship to develop the next generation of HIV researchers. Undertaking the following specific aims, the HU CFAR will continue to evolve, to meet the needs of its members and the NIH AIDS research priorities by promoting and facilitating collaborative, cross-disciplinary activities in AIDS research among CFAR members, serving as a model for collaborative inter-institutional interactions at Harvard. Briefly, we propose to: 1. Facilitate and expand synergistic multidisciplinary collaborations among the diverse and highly successful HU-affiliated HIV/AIDS researchers and their trainees 2. Promote new interactions and support innovative research initiatives capable of more effectively addressing key HIV/AIDS related research questions aimed at bringing an end to the epidemic 3. Attract, engage, support and mentor the next generation of Early Career Investigators in HIV/AIDS research

项目概要/摘要 全面的 本申请提议继续资助哈佛大学艾滋病研究中心 (HU CFAR)。 HU CFAR 是哈佛大学所有艾滋病研究的伞式组织，在教务长办公室下运作。 它代表哈佛的每所附属学校以及附属医院，包括丹娜—法伯癌症研究所 癌症研究所、贝斯以色列女执事医疗中心、波士顿儿童医院、马萨诸塞州综合医院 医院，布莱根妇女医院。此外，它还包括芬威健康 (Fenway Health)，将其覆盖范围扩大到更多 哈佛大学以外的临床人群和转化研究中心。 HU CFAR 建立合作关系 提供基础设施支持，以协调和促进基础、临床、行为、 艾滋病毒研究的转化和实施。研究人员的研究重点包括 分子病毒学、发病机制、宿主免疫反应、流行病学、治疗、疫苗预防和 送货。 CFAR 还监督 4 个科学项目（健康经济学和建模；HIV 疫苗；HIV 根除）以及 3 个科学工作组（青少年与艾滋病毒、艾滋病毒与老龄化；生殖 艾滋病毒感染人群的健康）。 HU CFAR 支持还确定了五个核心设施： 临床核心、生物统计学和生物信息学核心、人类免疫系统小鼠、核心高级 实验室技术核心、生物行为和社区科学核心。此外，还有一个行政 核心将提供战略规划和财政监督，发展和指导核心将提供支持 与科学计划和科学工作组的目标相关的创新试点项目，以及 为培养下一代艾滋病毒研究人员提供指导。具体开展以下工作 的目标，HU CFAR 将继续发展，以满足其成员和 NIH 艾滋病研究的需求 通过促进和促进 CFAR 之间艾滋病研究中的协作、跨学科活动来确定优先事项 成员，成为哈佛大学机构间协作互动的典范。简而言之，我们建议： 1. 促进和扩大多元化和高度协同的多学科合作 HU 附属的成功的艾滋病毒/艾滋病研究人员及其学员 2. 促进新的互动并支持能够更有效地开展创新研究活动 解决与艾滋病毒/艾滋病相关的关键研究问题，旨在结束这一流行病 3. 吸引、参与、支持和指导下一代艾滋病毒/艾滋病早期职业研究者 研究

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