Corrosion Fatigue Resistant and Intimal Hyperplasia Suppressive Biometal for Bioabsorbable Stents

用于生物可吸收支架的抗腐蚀疲劳和内膜增生抑制生物金属

• 批准号: 9816239
• 负责人: Jaroslaw W Drelich
• 金额: $ 36.97万
• 依托单位: MICHIGAN TECHNOLOGICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9816239
• 关键词: Abdomen; Absorbable Implants; Address; Age; Alloys; Anti-inflammatory; Aorta; Arteries; Behavior; Benchmarking; Biodegradation; Blood Vessels; Cells; Characteristics; Chronic; Complex; Coronary; Corrosion; Defect; Developed Countries; Developing Countries; Diet; Drops; Elements; Endothelium; Engineering; Ensure; Environment; Exhibits; Failure; Fatigue; Formulation; Fracture; Grain; Health; Heart Diseases; Human; Hyperplasia; Individual; Industrialization; Inflammatory; Inflammatory Response; Iron; Laboratories; Location; Magnesium; Mechanics; Metabolic Clearance Rate; Metals; Modeling; Obesity; Oxides; Patients; Performance; Periodicity; Phase; Physiological; Pilot Projects; Plasma; Precipitation; Procedures; Property; Rattus; Research; Resistance; Risk; Solubility; Stainless Steel; Stents; Stress; System; Temperature; Testing; Texture; Thick; Time; Toxic effect; Trace Elements; Work; Zinc; base; biomaterial compatibility; cardiovascular health; density; design; ductile; experience; falls; improved; in vivo; interest; mechanical load; mechanical properties; metallicity; novel; particle; prototype; response; scaffold; side effect

Summary Heart disease is of great societal interest due to its drastic impact on health in industrialized nations, especially in developed countries where obesity rates are high and the typical diet is not conducive to cardiovascular health. While invasive procedures are not desirable, they are often crucial to ensuring patient survival. The five million coronary stents administered world- wide each year remain present in the human artery for the lifetime of the patient. This has resulted in the emergence of several serious side effects. A bioabsorbable metal stent that harmlessly erodes away over time could minimize the normal chronic risks associated with permanent stents. Our laboratory has been working to refine the composition and microstructure of biodegradable Zn-based binary alloys and test their behavior in the vascular environment over the last four years in an effort to develop a metal with mechanical properties and biocompatibility required for endovascular stent applications. Having contributed enormously to the scientific understanding of Zn-based systems, we are now ready to develop more complex Zn-based alloys with 2-3 alloying elements that meet benchmark values for biodegradable stents, including: 1) have superior corrosion fatigue resistance that eliminates early stage (6 to 9 months) fracturing of biodegradable stents (common problem in Mg-based and Zn-based stents prototyped in the last several years); 2) maintain in vivo corrosion rates close to the 0.02 mm/year value; 3) exhibit >200 MPa yield strength, and >25-30% elongation to failure; and 4) demonstrate biocompatibility in terms of short- and long-term inflammatory responses, re-endothelialization, and suppressed intimal hyperplasia, similar or better than 316L stainless steel (industrial standard for stent materials).

概括 心脏病因其对工业化国家健康的巨大影响而受到社会极大关注。 国家，尤其是肥胖率高且典型饮食的发达国家 不利于心血管健康。虽然侵入性手术并不可取，但它们是 通常对于确保患者的生存至关重要。全球已植入 500 万个冠状动脉支架 在患者的一生中，每年都有大量的残留物存在于人体动脉中。这有 导致出现了一些严重的副作用。一种生物可吸收金属支架 随着时间的推移，无害地侵蚀掉，可以最大限度地减少与以下疾病相关的正常慢性风险： 永久性支架。 我们的实验室一直致力于细化可生物降解材料的成分和微观结构 锌基二元合金并测试它们在过去四年中在血管环境中的行为 多年来致力于开发一种具有机械性能和生物相容性的金属 血管内支架的应用。对科学理解做出了巨大贡献 锌基系统，我们现在准备开发更复杂的锌基合金，具有 2-3 符合可生物降解支架基准值的合金元素，包括：1) 卓越的耐腐蚀疲劳性能，可消除早期（6 至 9 个月）断裂 可生物降解支架（去年原型化的镁基和锌基支架的常见问题 几年）; 2）保持体内腐蚀率接近0.02毫米/年值； 3）展示 >200 MPa 屈服强度，>25-30% 断裂伸长率； 4）展示 短期和长期炎症反应、再内皮化方面的生物相容性， 并抑制内膜增生，与316L不锈钢（工业级）相似或更好 支架材料标准）。