Role of Preoperative Baroreflex Sensitivity on Postoperative and Persistent Pain after Thoracic Surgery

术前压力感受反射敏感性对胸外科术后和持续性疼痛的作用

• 批准号: 9809527
• 负责人: WILLIAM MAIXNER
• 金额: $ 24.15万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9809527
• 关键词: Acute; Age; Anti-inflammatory; Baroreflex; Biological Markers; Blood specimen; C-reactive protein; Comorbidity; Data; Future; Goals; Hour; Human; IL8 gene; Impairment; Inflammation; Inflammatory; Inflammatory Response; Interferon Type II; Interleukin-1 beta; Interleukin-6; Intervention Studies; Measures; Mediating; Nociception; Operative Surgical Procedures; Outcome; Pain; Pain intensity; Patients; Perioperative; Persistent pain; Postoperative Pain; Postoperative Period; Reflex action; Reporting; Research Design; Risk; Risk Factors; Role; Sensory; TNF gene; Thoracic Surgical Procedures; Time; Treatment Protocols; Video-Assisted Thoracic Surgery; Visit; biopsychosocial; clinical pain; minimally invasive; novel; opioid use; pain score; peripheral blood; psychologic; therapy design; treatment effect

The primary goal of this proposal is to establish Baroreflex Sensitivity (BRS) as a biomarker for acute postoperative pain (POP) and the likelihood of persistent postoperative pain (PPP) at the 3 month postoperative timepoint in patients undergoing video-assisted thoracic surgery (VATS). Our central hypothesis is that preoperative BRS is inversely associated with the magnitude and duration of POP during postoperative days 0-2 and the likelihood of PPP at 3 months throughout the postoperative observation by influencing nociceptive processing and surgically-induced inflammation. If this central hypothesis is confirmed then future interventional studies designed to enhance BRS will be developed with the goal of optimizing perioperative outcomes.

该提案的主要目标是建立压力反射敏感性（BRS）作为急性发作的生物标志物 术后疼痛 (POP) 和术后 3 个月持续疼痛 (PPP) 的可能性 接受电视胸腔镜手术（VATS）患者的术后时间点。我们的中央 假设术前 BRS 与 POP 的严重程度和持续时间呈负相关 术后 0-2 天期间以及术后 3 个月内发生 PPP 的可能性 通过影响伤害性处理和手术引起的炎症进行观察。如果这个中央 如果假设得到证实，那么未来旨在增强 BRS 的干预研究将被开发 优化围手术期结果的目标。