A Personalized Behavioral Intervention to Improve Physical Activity, Sleep and Cognition in Sedentary Older Adults

改善久坐老年人身体活动、睡眠和认知的个性化行为干预

基本信息

批准号：
9808108
负责人：
Junxin Li
金额：
$ 24.9万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-01 至 2022-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9808108
关键词：
Accelerometer Achievement Affect Aging Attention Behavior Therapy Biological Markers C-reactive protein Characteristics Circadian Rhythms Cognition Cognitive Complex Control Groups Dementia Devices Effectiveness Elderly Ensure Exercise Foundations Frequencies Future Goals Health Heart Rate Impaired cognition Individual Inflammatory Interleukin-1 beta Interleukin-6 Intervention Intervention Studies Learning Longitudinal cohort Mediating Mentors Mission Monitor Napping National Institute of Nursing Research Outcome Outcome Study Participant Pathway interactions Phase Physical Exercise Physical activity Pilot Projects Preparation Public Health Randomized Controlled Trials Reporting Research Personnel Retrospective Studies Risk Factors Serum Short-Term Memory Sleep Structure TNF gene Technology Testing Time Training United States Work Wrist base behavior change career career development circadian cognitive benefits cognitive function cognitive performance cohort cytokine exercise intervention follow-up healthy aging improved improvement on sleep innovation insight laboratory experience novel older men older women physical conditioning preservation processing speed prospective prototype sedentary sedentary lifestyle smart watch vigilance wearable device

项目摘要

PROJECT SUMMARY/ABSTRACT The proposed project aims to identify the optimal features of daytime napping and physical activity for cognition in older adults (K99) and examine the effects of an innovative, personalized behavioral intervention on promoting physical activity, healthy napping, sleep and cognitive function in sedentary older adults (R00). In the K99 phase, to ensure the successful completion of the R00 project and facilitate the achievement of my career development goals, I will follow an intensive training plan that incorporates courses, laboratory training, mentoring, and structured activities. In addition, a retrospective study will be conducted using two large longitudinal cohorts of older adults in the United States to examine the associations of daytime physical activity and nocturnal sleep with cognitive decline over 4-6 years. The K99 study will examine: 1) baseline associations of napping characteristics, physical activity and nocturnal sleep duration with cognition; 2) whether baseline napping, physical activity and nocturnal sleep duration predict cognitive decline at the 4-6 year follow-up; and 3) relationships between changes in physical activity and nocturnal sleep duration and changes in cognitive function at follow-up. Building off the K99, in the R00 phase, a randomized controlled trial will be conducted in older adults (without dementia) with both sedentary lifestyle and nocturnal sleep complaints to examine the effectiveness of a 24-week personalized behavioral intervention implemented with smartwatch technology on promoting physical activity, nocturnal sleep, and cognition compared against a control group; we have successfully tested this in a pilot study. Serum inflammatory biomarkers will be assessed to explore hypothesized mechanisms for associations among the study outcomes. In order to optimize outcomes at the subject level, a personalized physical activity plan will be calculated based on the individual’s characteristics, personal circadian rhythm at baseline, and the optimal characteristics of napping and physical activity that were identified in the K99 phase. The R00 study will examine: 1) whether the intervention increases participants’ non-nap period physical activity, optimizes napping duration, and enhances nocturnal sleep; 2) whether the intervention improves participants’ overall cognitive performance; 3) whether the relationship between the study intervention and cognitive performance is mediated by changes in physical activity, healthy nap duration, and nocturnal sleep duration; and 4) (exploratory aim) if the proposed intervention changes serum inflammatory biomarkers, including cytokines (IL-6, IL-1ß, TNF-α) and C-reactive protein, and whether these biomarkers relate to changes in physical activity, sleep, and cognitive function. Upon completion, this proposal will provide important insights on the optimal features of physical activity and napping for cognitive function. The proposed intervention may provide a novel way for older adults to optimize wellness and achieve active, healthy lives while aging, a key theme of the National Institute of Nursing Research in its mission to enhance public health. It will also build a strong foundation for my future career as an independent researcher.

项目概要/摘要该项目旨在确定白天小睡和体力活动对于认知的最佳特征老年人 (K99) 并检查创新的、个性化的行为干预对促进久坐老年人的身体活动、健康的午睡、睡眠和认知功能（R00）。 K99阶段，保证R00项目的顺利完成，促进我的目标的实现职业发展目标，我将遵循强化培训计划，包括课程、实验室培训、此外，还将利用两项大型活动进行回顾性研究。美国老年人的纵向队列研究白天体力活动的关联 K99 研究将检查：1) 基线关联。午睡特征、体力活动和夜间睡眠持续时间与认知的关系；2) 是否为基线；午睡、体力活动和夜间睡眠时间可预测 4-6 年随访时的认知能力下降；3) 身体活动和夜间睡眠时间的变化与认知变化之间的关系在 R00 阶段，将在 K99 的基础上进行随机对照试验。具有久坐生活方式和夜间睡眠抱怨的老年人（无痴呆症），以检查使用智能手表技术实施的 24 周个性化行为干预的有效性与对照组相比，促进身体活动、夜间睡眠和认知；在一项试点研究中成功测试了这一点，将评估血清炎症生物标志物以进行探索。促进研究结果之间的关联机制，以优化研究结果。学科层面，将根据个人特点计算个性化的身体活动计划，基线时的个人昼夜节律，以及午睡和身体活动的最佳特征在 K99 阶段确定的 R00 研究将检查：1）干预是否增加。参与者非午睡期间的身体活动，优化午睡时间，并增强夜间睡眠2)； 3）是否有关系研究干预和认知表现之间的关系是由体力活动的变化介导的，健康午睡持续时间和夜间睡眠持续时间；以及 4)（探索性目标）如果提议的干预措施发生变化血清炎症生物标志物，包括细胞因子（IL-6、IL-1ß、TNF-α）和 C 反应蛋白，以及是否这些生物标志物与身体活动、睡眠和认知功能的变化有关。该提案将为认知活动和小睡的最佳特征提供重要见解所提出的干预措施可能为老年人提供一种优化健康并实现目标的新方法。在老龄化过程中保持积极、健康的生活，这是国家护理研究所的一个关键主题，其使命是这也将为我未来作为一名独立研究员的职业生涯奠定坚实的基础。