RETINAL ELECTRICAL STIMULATION IN PHOTORECEPTOR LOSS

视网膜电刺激导致光感受器损失

• 批准号: 2383240
• 负责人: MARK S HUMAYUN
• 金额: $ 9.31万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2002-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2383240
• 关键词: bioengineering /biomedical engineering; blind aid; blindness; dogs; electron microscopy; electrophysiology; electrostimulus; eye fundus photography; eye prosthesis; histology; implant; light microscopy; longitudinal animal study; nonhuman therapy evaluation; ophthalmoscopy; retina degeneration; retinal bipolar neuron; retinitis pigmentosa; visual photoreceptor

DESCRIPTION (Adapted from applicant's abstract): By using electrical stimulation to bypass neurons which have become non-functional, implanted neural prostheses such as the cochlear implant have rehabilitated patients for whom there is no other treatment. The applicant proposes that a similar approach could benefit a subset of patients blind from retinitis pigmentosa and age-related macular degeneration, two leading causes of blindness. The results to date have supported this approach and show that vision compatible with mobility and large print reading is possible. The next critical step is to determine the maximum resolution affordable by such an approach. In this proposal, the applicant delineates key experiments necessary to achieve this goal.

描述（改编自申请人的摘要）：使用电气 刺激绕过已成为非功能，植入的神经元 神经假体（例如人工耳蜗植入物）已修复患者 没有其他待遇。 申请人提出类似的 方法可以使一部分患者从视网膜炎色素炎中受益 和与年龄有关的黄斑变性，这是失明的两个主要原因。 这 迄今为止的结果支持了这种方法，并表明了视力兼容 有了移动性和大型打印读数。 下一个关键步骤 是确定通过这种方法负担得起的最大分辨率。 在 该提案，申请人描述了实现必要的关键实验 这个目标。