LATE EFFECTS IN WILMS TUMOR SURVIVORS AND OFFSPRING

对维尔姆斯肿瘤幸存者和后代的迟发影响

• 批准号: 2414221
• 负责人: NORMAN E BRESLOW
• 金额: $ 37.13万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-15 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2414221
• 关键词: Wilms' tumor; cancer registry /resource; cancer risk; child (0-11); clinical research; combination cancer therapy; congenital disorders; congestive heart failure; disease /disorder proneness /risk; family genetics; fertility; genetic disorder; human data; human subject; human therapy evaluation; longitudinal human study; neoplasm /cancer chemotherapy; neoplasm /cancer epidemiology; neoplasm /cancer genetics; neoplasm /cancer radiation therapy; neoplasm /cancer relapse /recurrence; pediatric neoplasm /cancer; pregnancy disorder; renal failure; young adult human (21-34)

DESCRIPTION: (Adapted from the Applicant's Abstract): This proposal is to continue the follow-up of children and young adults who were treated successfully for Wilms tumor on protocol studies of the National Wilms Tumor Study Group (NWTSG). Patients will be contacted annually and those who become lost will be actively traced. Information on health status and key events will be obtained from periodic physical exams and medical histories, with medical records used to confirm reproductive outcomes and key diagnoses. The goals are to help elucidate the genetic events involved in the pathogenesis of Wilms tumor, to estimate the risk of adverse pregnancy outcomes and congenital defects in offspring, and to determine the risks of second malignant neoplasms, congestive heart failure and renal failure in survivors.Adjuvant treatment for Wilms tumor involves the combination of several chemotherapeutic agents with or without radiation therapy. This facilitates comparison of rates of key events among randomized subgroups of patients that differ with respect to the dose and duration of use of radiation and specific drugs. Data on the occurrence of Wilms tumor in family members and offspring will facilitate testing of specific genetic models and the estimation of recurrence risks for use by clinical geneticists in counselling affected families. Although initially believed to exemplify Knudson's two stage mutational model in a manner similar to retinoblastoma, the genetics of Wilms tumor is now recognized to be more complex and heterogeneous. The proposed epidemiologic studies will provide insights regarding carcinogenic mechanisms that can be used to orient and interpret the laboratory studies. Collaboration with groups of molecular biologists, providing them national access to informative subgroups of patients, will speed their discoveries.

描述：（根据申请人的摘要改编）：此提案是 继续对接受治疗的儿童和年轻人进行随访 在国家威尔姆斯肿瘤方案研究中成功地为威尔姆斯肿瘤 研究组（NWTSG）。 每年将与患者联系 迷失将被积极追踪。 有关健康状况和密钥的信息 事件将从定期的身体检查和病史中获得 用来确认生殖结果和钥匙的病历 诊断。 目标是帮助阐明涉及的遗传事件 威尔姆斯肿瘤的发病机理，以估计妊娠不良的风险 后代的结果和先天性缺陷，并确定 第二个恶性肿瘤，充血性心力衰竭和肾衰竭 幸存者。威尔姆斯肿瘤的辅助治疗涉及 有或没有放射治疗的几种化学治疗剂。 这 促进比较随机亚组之间关键事件率的比较 在剂量和使用时间不同的患者 辐射和特定药物。 有关威尔姆斯肿瘤发生的数据 家庭成员和后代将有助于测试特定的遗传 模型和临床使用的复发风险 咨询受影响家庭的遗传学家。 虽然最初相信 以类似的方式来体现诺森的两个阶段突变模型 视网膜母细胞瘤，威尔姆斯肿瘤的遗传学现在被认为是更多 复杂而异构。 拟议的流行病学研究将提供 有关可用于定向和的致癌机制的见解 解释实验室研究。 与分子组合作 生物学家，为他们提供全国访问信息的访问 患者将加快发现的速度。