JACKSON HEART STUDY (JHS) GRADUATE TRAINING AND EDUCATION CENTER (GTEC) - TASK AREA B

杰克逊心脏研究 (JHS) 研究生培训和教育中心 (GTEC) - 任务区 B

• 批准号: 10972975
• 负责人: MARINELLE PAYTON
• 金额: $ 220万
• 依托单位: JACKSON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-13 至 2025-08-12
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10972975
• 关键词: JACKSON; HEART; STUDY; JHS; GRADUATE

The Jackson Heart Study (JHS) (https://www.jacksonheartstudy.org/) initiated in 1998 is a longitudinal investigation of genetic and environmental risk factors associated with the disproportionate burden of cardiovascular disease in African Americans. In addition, the JHS conducts community education and outreach activities to promote healthy lifestyles and reduce disease risk burden, undergraduate and graduate level research training programs, and high school science and math enrichment programs to prepare and encourage underrepresented minority students to pursue biomedical careers. The JHS is funded by the National Heart, Lung and Blood Institute (NHLBI) and the National Institute on Minority Health and Health Disparities (NIMHD). The JHS represents an expansion of the Jackson Field Center of the Atherosclerosis Risk in Communities (ARIC) study (http://www2.cscc.unc.edu/aric/) to broaden data collection in an African American population and to increase access to and participation of African American populations and scientists in biomedical research and professions. The JHS recruited 5306 African American residents living in the Jackson, Mississippi, metropolitan area of Hinds, Madison, and Rankin Counties. Participants were enrolled from 4 recruitment pools: random, 17%; volunteer, 30%; currently enrolled in the ARIC Study, 31% and secondary family members, 22%. Recruitment was limited to non-institutionalized adult African American men and women, 35-84 years old, except in a nested family cohort where those 21 to 34 years of age were also eligible. The final cohort of participants enrolled during the baseline exam included 6.6% of all African American men and women residents of the Jackson Mississippi Metropolitan Statistical Area aged 35-84 (N=76,426, US Census 2000). Among these participants, approximately 3400 gave consent that allows genetic research. JHS participants received three back-to-back clinical examinations (Exam 1, 2000-2004; Exam 2, 2005-2008; and Exam 3, 2009-2013) that have generated extensive longitudinal data on traditional and putative cardiovascular disease risk factors and measures of subclinical cardiovascular disease from echocardiography, cardiac magnetic resonance imaging and computed tomography scans. Biological samples (i.e., blood and urine) have been assayed for putative biochemical risk factors and stored for future research. DNA has been extracted and lymphocytes have been cryopreserved for studies of candidate genes, genome-wide scanning, expression, and other –omics investigations. In addition, JHS participants are contacted annually by telephone to update personal and health information including vital status, interim medical events, hospitalizations, functional status and sociocultural information. Ongoing cohort surveillance for cardiovascular events (i.e., coronary heart disease and related procedures, heart failure, and stroke) and deaths also involves data linkage with hospital discharge lists of JHS catchment area hospitals and the National Death Index (NDI). Medical records of cardiovascular disease related hospitalizations and death certificates are abstracted and used for adjudication of cardiovascular events and related deaths. The current JHS contracts (2018-2024) will include a clinical examination (Exam 4, 2/2020-11/2022) and investigation of the link between cardiovascular health and brain health.

1998年启动的杰克逊心脏研究（JHS）（https://www.jacksonheartstudy.org/）是对非裔美国人心血管疾病不成比例的伯恩（Burnen）遗传和环境危险因素的纵向研究。此外，JHS开展社区教育和外展活动，以促进健康的生活方式，并降低疾病风险伯恩，本科和研究生级的研究培训计划以及高中科学和数学丰富计划，以准备和鼓励代表性不足的少数群体从事生物医学生涯。 JHS由国家心脏，肺和血液研究所（NHLBI）和国家少数民族健康与健康差异（NIMHD）资助。 JHS代表了社区动脉粥样硬化风险（ARIC）研究（http://wwwww2.cscc.unc.edu/aric/）的杰克逊野战中心的扩展，以扩大非洲裔美国人口的数据收集，并增加非裔美国人人口和科学家参与生物医学研究和专业的机会。 JHS招募了5306名居住在杰克逊，密西西比州，欣德斯大都会，麦迪逊和兰金县的非裔美国人居民。参与者从4个招聘池中招募：随机，17％；志愿者，30％；目前正在参加ARIC研究，31％和中学家庭成员，22％。招聘仅限于35 - 84岁的非机构化成年非裔美国人男女，除了在一个嵌套的家庭队列中，那里的21至34岁也有资格。在基线考试期间入学的最后一组参与者包括6.6％的非裔美国人男女居民，杰克逊密西西比州大都会统计区为35-84岁（n = 76,426，美国人口普查，2000年）。在这些参与者中，大约有3400人同意允许遗传研究。 JHS参与者接受了三项背靠背临床检查（考试1，2000-2004;考试2，2005-2008;和考试3，2009-2013），这些检查对传统和假定的心血管疾病危险因素和超细节性心血管疾病的措施产生了广泛的纵向数据，来自eChocarcartiography，Cardiac concance and tomcraphy scans tomection tomecraphy tomection and tomcraphy tomcraphy tomecraphy and tomcraphy。已经为假定的生化危险因素分配了生物样品（即血液和尿液），并存储用于未来的研究。 DNA已被提取，淋巴细胞已被冷冻保存，用于研究候选基因，全基因组扫描，表达和其他 - 组学研究。此外，每年通过电话与JHS参与者联系，以更新个人和健康信息，包括重要的状态，临时医疗活动，住院，功能状况和社会文化信息。对心血管事件（即冠心病及相关程序，心力衰竭和中风）的持续队列监视以及死亡还涉及与JHS集水区医院的医院出院清单以及国家死亡指数（NDI）的数据联系。与心血管疾病相关的住院和死亡证明的病历被提取，并用于调整心血管事件和相关死亡。当前的JHS合同（2018-2024）将包括临床检查（考试4、2/2020-11/2022），并研究心血管健康与大脑健康之间的联系。