NATIONAL FERRET RESOURCE AND RESEARCH CENTER ON LUNG DISEASE

国家雪貂肺病资源与研究中心

基本信息

批准号：
10929919
负责人：
JESSICA BOYLE
金额：
$ 113.19万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-23 至 2024-09-22
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10929919
关键词：
Advisory Committees Age Alveolar Cell Animal Model Animals Anti-Inflammatory Agents Antibodies Biological Biology Body Fluids Catalogs Cell Therapy Cells Communities Complementary DNA Contracts Cystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator Data Databases Decision Making Deposition Development Disease Disease model Educational workshop Enzyme-Linked Immunosorbent Assay Farm Ferrets Fluorescence-Activated Cell Sorting Foundations Funding Gene Expression Genes Genetic Genetic Engineering Genetically Modified Animals Genotype Gland Goals Grant Human Human Resources Immunoprecipitation In Situ Hybridization Industrialization International Knock-in Knock-out Leadership Left Lung Lung diseases Maps Messenger RNA Methods Modeling Mus National Heart, Lung, and Blood Institute Phenotype Preparation Protocols documentation Pulmonary function tests RNA Reagent Records Research Research Contracts Research Personnel Resources Sampling Site Source Specimen Submucosa Technology Testing Therapeutic Agents Tissue Model Tissue Sample Tissues Trachea Training Transgenic Organisms United States Department of Agriculture United States National Institutes of Health Western Blotting Work Xenograft procedure cell type experimental study material transfer agreement member pharmacologic programs recombinant virus repository sample collection single-cell RNA sequencing stem cell biology stem cell therapy stem cells symposium therapeutic evaluation web site

项目摘要

During the proposed funding period, the NFLRRC seeks to facilitate the utilization of ferret models for lung disease by generating genetically modified animals, biological specimens, reagents, and data easily accessible, and by expanding the genetic toolbox for ferret-based research on lung biology. Our work will focus on three objectives: 1) Distribute ferrets, and biologic specimens from ferrets, for the study of lung disease and lung biology and for the testing of therapeutics; 2) Generate additional genetic ferret models relevant to lung disease and lung biology; and 3) Maintain and build a repository of reagents and information needed for ferret research. The expected accomplishments of establishing the proposed NFLRRC are facilitation (at both the technical and fiscal levels) of the utilization of ferret models in the study of lung disease, for which other animal models are not well suited. This undertaking has had, and will continue to have, a broad impact on our understanding of diseases for which other animal models have failed to accurately recapitulate the human phenotypes.

在拟议的资金期间，NFLRRC试图促进雪貂模型的利用通过产生转基因动物，生物标本，试剂和数据来轻松产生疾病可访问，并通过扩展基于雪貂的肺部生物学研究的遗传工具箱。我们的工作将集中关于三个目标：1）从雪貂分发雪貂和生物标本，以研究肺部疾病和肺部生物学和治疗学测试； 2）产生与肺部疾病和肺部生物学有关的其他遗传雪貂模型； 3）维护和建立雪貂研究所需的试剂和信息的存储库。建立拟议的NFLRRC的预期成就是促进的（在技术上都在肺部疾病研究中利用雪貂模型的利用水平），其他动物模型不适合适合。这项事业已经并且将继续对我们的理解产生广泛的影响其他动物模型未能准确概括人类表型的疾病。