Base Title: PREVENT Preclinical Drug Development Program: Preclinical Efficacy and Intermediate Endpoint BiomarkersTask Order Title: Colorectal Cancer (CRC) Prevention by TPST-1495 in PIRC rat mod

基本标题：预防临床前药物开发计划：临床前功效和中间终点生物标志物任务顺序标题：TPST-1495 在 PIRC 大鼠模型中预防结直肠癌 (CRC)

• 批准号: 10927554
• 负责人: CHINTHALAPALLY RAO
• 金额: $ 114.04万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-11 至 2026-09-10
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10927554
• 关键词: American Association of Cancer Research; Animal Cancer Model; Animals; Apoptosis; Biological Markers; Blood Chemical Analysis; Body Water; Body Weight; Cell Proliferation; Chemopreventive Agent; Colon; Colon Carcinoma; Colonic Polyps; Colonoscopy; Colorectal Neoplasms; Communities; Consultations; Contractor; Contracts; Development; Dinoprostone; Dose; Familial Adenomatous Polyposis Syndrome; Funding; Government; Histology; Human Resources; Inbred F344 Rats; Incidence; Inflammation; Kidney; Literature; Liver; Lung; Malignant Neoplasms; Measurement; Measures; Mission; Modeling; Monitor; Notification; Oral; Oral Administration; Organ; Pathway interactions; Plasma; Polyps; Preclinical Drug Development; Principal Investigator; Program Development; Progress Reports; Rattus; Reporting; Research; Safety; Sampling; Schedule; Signal Pathway; Slide; Small Intestinal Polyp; Spleen; Sulindac; Technology; Testing; Toxic effect; Toxicology; Travel; Tumor Burden; WFDC2 gene; Water consumption; Work; base; cancer prevention; carcinogenesis; clinical translation; colorectal cancer prevention; efficacy evaluation; efficacy study; immunoregulation; innovation; meetings; neoplastic cell; novel; posters; preclinical efficacy; predictive marker; preventive intervention; programs; research and development; symposium; treatment duration; tumor; vaccinology; American Association of Cancer Research; Animal Cancer Model; Animals; Apoptosis; Biological Markers; Blood Chemical Analysis; Body Water; Body Weight; Cell Proliferation; Chemopreventive Agent; Colon; Colon Carcinoma; Colonic Polyps; Colonoscopy; Colorectal Neoplasms; Communities; Consultations; Contractor; Contracts; Development; Dinoprostone; Dose; Familial Adenomatous Polyposis Syndrome; Funding; Government; Histology; Human Resources; Inbred F344 Rats; Incidence; Inflammation; Kidney; Literature; Liver; Lung; Malignant Neoplasms; Measurement; Measures; Mission; Modeling; Monitor; Notification; Oral; Oral Administration; Organ; Pathway interactions; Plasma; Polyps; Preclinical Drug Development; Principal Investigator; Program Development; Progress Reports; Rattus; Reporting; Research; Safety; Sampling; Schedule; Signal Pathway; Slide; Small Intestinal Polyp; Spleen; Sulindac; Technology; Testing; Toxic effect; Toxicology; Travel; Tumor Burden; WFDC2 gene; Water consumption; Work; base; cancer prevention; carcinogenesis; clinical translation; colorectal cancer prevention; efficacy evaluation; efficacy study; immunoregulation; innovation; meetings; neoplastic cell; novel; posters; preclinical efficacy; predictive marker; preventive intervention; programs; research and development; symposium; treatment duration; tumor; vaccinology

The purpose of this Task Order is to evaluate the efficacy and preliminary safety of TPST-1495 for the prevention of Colorectal Cancer (CRC) associated with Familial Adenomatous Polyposis (FAP) in PIRC rat model. The Government will provide TPST-1495 to the Contractor for use under the effort described in the Statement of Work.

该任务顺序的目的是评估TPST-1495在PIRC大鼠模型中与家族性腺瘤性息肉病（FAP）相关的结直肠癌（CRC）的疗效和初步安全性。政府将根据工作声明中描述的努力向承包商提供TPST-1495。