California Precision Medicine Consortium

加州精准医学联盟

• 批准号: 9355296
• 负责人: HODA A ANTON-CULVER
• 金额: $ 127.79万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-27 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9355296
• 关键词: California; Precision; Medicine; Consortium

The PREcision Medicine Initiative Enrollment and Retention (PREMIER) cohort will be assembled to reflect the diverse populations of California. Our goal is to enroll a minimum of 10,000 representative participants during a 12-month period. Participants will be consented using an NIH central IRB protocol and will share biospecimens, anthropometric data (e.g., waist circumference), survey responses, and electronic health records (EHRs) with the PMI Cohort Program (PMI-CP). Participants will be engaged through multiple media including non-proprietary applications developed by the PMI-CP. The inclusion of six large healthcare provider organizations throughout California in the PREMIER cohort will ensure that we meet our enrollment goals. To facilitate interactions with PMI-CP leadership, there will be a single program management office (PMO) at UCSD that will be charged with all communications to site PIs at each institution. Importantly, our large, diverse consortium of seasoned investigators has a long history of past collaboration and productive scientific interactions, creating substantial efficiencies in the use of common research resources, providing further assurance that we will fulfill our contractual obligations. This collaboration included the transformation and periodic updating of EHRs from all our patients (>10 million patients in our six initial participating institutions) into the Observational Medical Outcomes Partnership (OMOP) and PCORnet common data models (CDM). Data from PMI participants will be centralized at UCSD, which will submit these data to the Data and Research Support Center (DRSC). We expect to be in close contact with the Participant Technology Center (PTC) and the DRSC, as well as with NIH administration to ensure that PREMIER members are active participants in various PMI-CP Working Groups. We are ready to implement the NIH Central IRB protocol, and quickly adapt existing processes or adopt new ones to conform to the PMI-CP protocols.

PREcision Medicine Initiative 的入组和保留 (PREMIER) 队列将进行汇总，以反映 加利福尼亚州的不同人口。我们的目标是在活动期间至少招募 10,000 名代表参与者 12个月期限。参与者将使用 NIH 中央 IRB 协议获得同意，并将共享生物样本， 人体测量数据（例如腰围）、调查回复和电子健康记录 (EHR) PMI 队列计划 (PMI-CP)。参与者将通过多种媒体参与，包括非专有媒体 PMI-CP 开发的应用程序。整个过程中纳入了六家大型医疗保健提供者组织 加州的 PREMIER 队列将确保我们实现我们的入学目标。为了方便与 PMI-CP 领导，UCSD 将设立一个项目管理办公室 (PMO)，负责 与每个机构的现场 PI 的所有通信。重要的是，我们由经验丰富的大型多元化财团组成 研究人员过去的合作和富有成效的科学互动有着悠久的历史，创造了大量的成果 提高共同研究资源的使用效率，进一步保证我们将实现我们的目标 合同义务。这项合作包括对来自所有国家的电子病历进行改造和定期更新。 我们的患者（在我们的六个初始参与机构中超过 1000 万患者）进入观察性医疗 结果合作伙伴关系 (OMOP) 和 PCORnet 通用数据模型 (CDM)。 PMI 参与者的数据将 集中在加州大学圣地亚哥分校，它将把这些数据提交给数据和研究支持中心（DRSC）。我们期望 与参与者技术中心 (PTC) 和 DRSC 以及 NIH 保持密切联系 确保 PREMIER 成员积极参与各个 PMI-CP 工作组。 我们已准备好实施 NIH 中央 IRB 协议，并快速调整现有流程或采用新流程 符合 PMI-CP 协议。