Johns Hopkins Alzheimer's Disease Research Center

约翰·霍普金斯大学阿尔茨海默病研究中心

基本信息

批准号：
10591542
负责人：
MARILYN S. ALBERT
金额：
$ 318.09万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-15 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10591542
关键词：
Acceleration Aging Alzheimer&apos s Disease Alzheimer&apos s disease patient Alzheimer&apos s disease related dementia Baltimore Basic Science Behavioral Biological Markers Biological Models Biostatistics Core Cancer Education Grant Program Center Core Grants Clinical Clinical Research Clinical Trials Collaborations Communities Data Data Analyses Dedications Development Disease Education Enrollment Environment Event Fostering Funding Funding Agency Future Goals Grant Growth Human Individual Institution Intramural Research Program Joints K-Series Research Career Programs Laboratories Leadership Link Longitudinal Studies Mentorship Methodology Methods Mind Molecular National Institute on Aging Neurosciences Participant Patient Care Patients Phase Pilot Projects Process Program Description Research Research Personnel Research Training Resources Scientific Advances and Accomplishments Source Strategic Planning Talents Therapeutic Tissue Banks Tissues Training Training Support Translating Universities Work brain tissue data management design education research educational atmosphere human model improved innovation insight interest meetings neuropathology next generation outreach pre-clinical programs recruit research study senior faculty

Acceleration Aging Alzheimer&apos s Disease Alzheimer&apos s disease patient Alzheimer&apos s disease related dementia Baltimore Basic Science Behavioral Biological Markers Biological Models Biostatistics Core Cancer Education Grant Program Center Core Grants Clinical Clinical Research Clinical Trials Collaborations Communities Data Data Analyses Dedications Development Disease Education Enrollment Environment Event Fostering Funding Funding Agency Future Goals Grant Growth Human Individual Institution Intramural Research Program Joints K-Series Research Career Programs Laboratories Leadership Link Longitudinal Studies Mentorship Methodology Methods Mind Molecular National Institute on Aging Neurosciences Participant Patient Care Patients Phase Pilot Projects Process Program Description Research Research Personnel Research Training Resources Scientific Advances and Accomplishments Source Strategic Planning Talents Therapeutic Tissue Banks Tissues Training Training Support Translating Universities Work brain tissue data management design education research educational atmosphere human model improved innovation insight interest meetings neuropathology next generation outreach pre-clinical programs recruit research study senior faculty

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项目摘要

OVERALL – PROJECT SUMMARY/ ABSTRACT The Johns Hopkins Alzheimer's Disease Research Center (JHADRC) is an integrated program of investigators whose overarching goal is to improve understanding of the earliest phases of AD and to expand therapeutic approaches. The overall scientific focus of the JHADRC is on the earliest stages of AD and related disorders in humans and in model systems, through characterizing the earliest clinical and pathophysiological processes, and by identifying cellular and molecular events that contribute to the abnormalities in model systems that capture aspects of the human disorders. We also focus efforts on improving care of patients in the symptomatic phases of disease. We have made substantial progress with these research goals during the current funding cycle, supported by a P50 center grant, and propose to continue and expand this work in the next funding cycle, through a P30 grant mechanism. The proposed Center consists of 6 Cores and one component : (1) the Administrative Core (Core A), (2) the Clinical Core (Core B), (3) the Data Management and Biostatistics Core (Core C), (4) the Neuropathology Core (Core D), (5) the Outreach, Recruitment and Engagement Core (Core E), (6) the Biomarker Core (Core F) and (7) the Research Education Component (REC). In this application we are also including funds for 3 Developmental Projects; we anticipate funding one developmental project for 2 years and two developmental projects for 3 years each.

总体 - 项目摘要/摘要约翰·霍普金斯·阿尔茨海默氏病研究中心（JHADRC）是一个综合计划其总体目标是提高对AD最早阶段的理解并扩大治疗方法。 JHADRC的总体科学重点是广告和相关疾病的最早阶段人类和模型系统中，通过表征最早的临床和病理生理过程，通过鉴定细胞和分子事件，这些事件导致模型系统中的异常捕获人类疾病的各个方面。我们还专注于改善对患者的护理疾病的有症状阶段。我们在这些研究目标中取得了重大进展当前的筹资周期，得到P50中心赠款的支持，并提议继续进行和扩展这项工作下一个资金周期，通过P30赠款机制。拟议的中心由6个核心和一个组成组件：（1）行政核心（核心A），（2）临床核心（核心B），（3）数据管理和生物统计学核心（核心C），（4）神经病理学核心（核心D），（5）外展，招聘和参与核心（核心E），（6）生物标志物核心（核心F）和（7）研究教育部分（rec）。在此应用程序中，我们还包括用于3个发展项目的资金；我们预计会资助一个开发项目2年和两个发展项目，分别为3年。