Midcareer Investigator Award in Patient-Oriented Research: Yael Schenker, MD, MAS

以患者为导向的研究中的职业生涯中期研究员奖：Yael Schenker，医学博士，MAS

• 批准号: 10592288
• 负责人: Yael Schenker
• 金额: $ 18.46万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10592288
• 关键词: Address; Adult; Advanced Malignant Neoplasm; Age; Aging; Attention; Award; Behavior Therapy; Caregiver Burden; Caregivers; Caring; Chronic; Clinical; Clinical Investigator; Cognition; Collaborations; Communication; Compassion; Computerized Medical Record; Data; Data Set; Dedications; Diagnosis; Discipline; Disease; Educational Curriculum; Elderly; Enrollment; Environment; Faculty; Family Caregiver; Fostering; Foundations; Funding; Future; Geriatric Assessment; Geriatrics; Goals; Grant; Infrastructure; Intervention; Intervention Studies; Intervention Trial; Investigation; Learning; Malignant Neoplasms; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Modeling; Morbidity - disease rate; Office Nursing; Older Population; Oncology; Outcome; Palliative Care; Patients; Personal Satisfaction; Policies; Population; Positioning Attribute; Postdoctoral Fellow; Pragmatic clinical trial; Public Health; Quality of Care; Quality of life; Reporting; Research; Research Personnel; Research Training; Resources; Role; Social support; Students; Techniques; Testing; Thinking; Time; Training; Universities; Update; Visit; Work; age related; care delivery; care seeking; career; career development; design; experience; improved; improved outcome; innovation; longitudinal dataset; medical specialties; mindfulness; next generation; novel; older patient; outreach; palliative; preference; professor; programs; resilience; skills; student mentoring; therapy design; therapy development; trial design

ABSTRACT: The growing population of older adults with advanced cancer experiences significant public health problems, including steep declines in quality of life, receipt of care that does not reflect patients' values and preferences, and high rates of caregiver burden. Inadequate attention to patient priorities and age-related concerns (e.g., function, cognition, and social support)—contribute to morbidity in this population. The emerging field of geriatric palliative care seeks to address age-related concerns and align care with patient goals over the trajectory of chronic and serious illness. The overarching goal of this K24 proposal is to enhance the candidate's mentorship of students, fellows, and junior faculty pursuing geriatric palliative care research, with a particular focus on identifying unmet geriatric palliative care needs and developing and testing interventions to improve quality of life and goal-concordant care for older patients with advanced cancer. As a successful mid-career investigator with a track record of leading successful palliative intervention trials with seriously ill older patients, the candidate is well-positioned to mentor the next generation of aging researchers. This award will leverage an outstanding longitudinal dataset of over 400 audio-recorded `primary' palliative care visits with older patients with advanced cancer and longitudinal patient- and caregiver-reported outcomes to explore optimal geriatric palliative care intervention designs. The research aims are to (1) characterize communication about age-related concerns in primary palliative care visits with older adults with advanced cancer and their family caregivers; (2) identify missed opportunities for addressing age- related concerns in primary palliative care visits for older adults with advanced cancer and their family caregivers; and (3) refine a conceptual model for primary palliative care delivery that incorporates age- related concerns and can be optimized to improve quality of life for older adults with advanced cancer. The K24 award will provide protected time for the candidate to update and expand her mentorship program, building bridges between researchers in geriatrics, palliative care and oncology. She will leverage outstanding aging research and mentoring resources available at the University of Pittsburgh; learn new skills to foster inquiry, wellbeing and resilience among trainees; and create a Junior Faculty Visiting Professor Program for geriatric palliative care researchers. This proposal is significant and innovative because it will support new clinical investigators using novel mentoring techniques and develop pilot data to inform large-scale trials addressing deficiencies in quality of care for a burgeoning population of older adults with advanced cancer. It is highly feasible because the candidate is a committed mentor with ongoing R01 funding, from an outstanding research environment with strong geriatrics programs and a large pool of potential mentees.

摘要：患有晚期癌症经历的老年人不断增长 公共卫生问题，包括生活质量的急剧下降，收到不反映的护理 患者的价值和偏好，以及伯恩（Burnen）的高照顾者。注意患者的注意力不足 优先事项和与年龄有关的问题（例如功能，认知和社会支持） - 该人群的发病率。老年姑息治疗的新兴领域旨在解决与年龄有关的问题 关注和使护理与患者目标有关慢性病和严重疾病的轨迹。 这项K24提案的总体目标是增强候选人对学生，研究员的心态 和从事老年姑息治疗研究的初级教师，特别着眼于识别未满足 老年姑息治疗需求以及制定和测试干预措施以改善生活质量和 针对老年晚期癌症患者的目标符合护理。作为成功的中期调查员 具有领先的成功姑息干预试验的记录，与年龄较大的患者进行 候选人的位置很好，可以指导下一代老龄化研究人员。这个奖项将 利用超过400个音频录制的“主要”姑息治疗访问的未出色纵向数据集 老年患者患有晚期癌症和纵向患者和护理人员报告的结果 探索最佳的老年姑息治疗干预设计。研究目的是（1）表征 与老年人初级姑息治疗访问中有关年龄有关的问题的沟通 晚期癌症及其家庭护理人员； （2）确定未解决年龄的机会 - 针对晚期癌症老年人及其家人的初级姑息治疗访问的相关问题 照顾者； （3）完善一个主要姑息治疗交付的概念模型，该模型结合了年龄 - 相关问题，可以优化以改善晚期癌症老年人的生活质量。 K24奖将为候选人提供受保护的时间更新和扩展她的精神训练 计划，在老年医学，姑息治疗和肿瘤学领域的研究人员之间建造桥梁。她会的 利用匹兹堡大学获得的杰出老龄化研究和心理资源； 学习新技能，以培养学员的询问，福祉和韧性；并创建一个初级教师 老年姑息治疗研究人员的客座教授计划。该提议很重要， 创新，因为它将使用新颖的心理技术支持新的临床研究人员 制定试点数据，以告知大规模试验，以解决水牛的护理质量缺陷 老年人患有晚期癌症的人群。这是非常可行的，因为候选人是 从持续不断的R01资金进行精神上的精神，来自杰出的研究环境 老年医学计划和大量潜在月经。