Penn PET Addiction Center of Excellence (Penn PACE)

宾夕法尼亚州 PET 成瘾卓越中心 (Penn PACE)

基本信息

批准号：
9794253
负责人：
HENRY RICHARD KRANZLER
金额：
$ 176.27万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-15 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9794253
关键词：
Area Biological Markers Biometry Brain Buprenorphine Caring Clinical Clinical Data Clinical Management Clinical Research Collaborations Comorbidity Complex Controlled Clinical Trials Coupled Data Data Analyses Depression and Suicide Development Disease Dose Ensure Epidemic Evaluation Experimental Designs Faculty Feeling suicidal Foundations Funding Future Genetic Variation Goals Grant HIV HIV Infections Harm Reduction Heart Image Individual Differences Infrastructure Lead Mental Depression Mentorship Methadone Modeling Monitor Morbidity - disease rate Names National Institute of Drug Abuse Neurobiology Operations Research Opiate Addiction Opioid Opioid Receptor Overdose Oxidative Stress Participant Patient Care Patients Pennsylvania Persons Pharmaceutical Preparations Pilot Projects Positron-Emission Tomography Process Productivity Psychiatry Radiochemistry Radiology Specialty Recording of previous events Request for Applications Research Research Personnel Resources Risk Role Scanning Science Scientist Services Strategic Planning Suicide Technical Expertise Therapeutic Toxic effect Training Training Programs Translational Research Translations Treatment outcome United States National Institutes of Health Universities addiction base career career development clinical care clinical infrastructure delta opioid receptor design disorder later incidence prevention dosimetry illicit opioid image processing imaging properties imaging scientist imaging study improved individualized medicine innovation instrumentation interdisciplinary collaboration kappa opioid receptors medical schools molecular imaging mortality neurobiological mechanism neurochemistry neuroimaging neuroinflammation next generation novel strategies opioid use disorder pain relief prescription opioid professor programs radiotracer ranpirnase receptor recruit response suicidal risk synergism treatment response treatment trial

项目摘要

OVERALL ABSTRACT This is a revised application requesting resources to create a NIDA P30 Core Center of Excellence Program at the University of Pennsylvania focused on studying the neurobiology of opiate use disorders (OUDs). This new center will focus on Positron Emission Tomography (PET) studies in patients seeking treatment at the Center for the Studies of Addiction (CSA) at the Perelman School of Medicine. The University of Pennsylvania has a long history in two key areas that serve as the foundation of this P30 Center of Excellence, the development of novel strategies for the opiate use disorders, and PET imaging studies of brain function. The name of the proposed center is the Penn PET Addiction Center of Excellence (Penn PACE), and represents a collaborative effort between the Departments of Radiology and Psychiatry at Penn. A key addition to this revised application is the inclusion of Yale University in this P30 Center. The center will initially focus on opioid receptors in opioid sensitivity, addiction, and suicide, and the role of oxidative stress and neuroinflammation in OUDs. This center takes advantage of unique resources at both the University of Pennsylvania and Yale University. The PIs of the Center are Dr. Robert H. Mach, the Britton Chance Professor of Radiology, Dr. Henry Kranzler, the Benjamin Rush Professor of Psychiatry, and Dr. Caryn Lerman, the John Glick Professor of Psychiatry and Vice Dean for Strategic Initiatives at Penn. Another key person is Dr. Richard Carson of the Yale University PET Center; Dr. Carson will lead the research effort at Yale University and direct the data analysis component of the Imaging Core. He is also the Co-Director of the Imaging Core with Dr. David Mankoff at Penn. The center consists of an Administrative Core and three research cores: Radiochemistry, Imaging and Clinical Core. Central to this center is the Pilot Project Core, which consists of a panel of identified and potential pilot projects by NIDA-funded investigators who use the opportunities provided by this P30 Core Center of Excellence Program to expand their research programs. We anticipate that the Penn PACE will lead to a significant advance in our understanding of the neurobiological mechanisms of opiate use disorders and neuroinflammation in a manner only possible through the combination of tightly-controlled clinical trials coupled with the unique molecular imaging properties provided by PET.

总体摘要这是一个修订后的申请，需要资源来创建 NIDA P30 核心卓越中心宾夕法尼亚大学的项目重点研究阿片类药物使用障碍的神经生物学（OUD）。这个新中心将专注于对寻求治疗的患者进行正电子发射断层扫描（PET）研究佩雷尔曼医学院成瘾研究中心 (CSA) 的治疗。这宾夕法尼亚大学在两个关键领域拥有悠久的历史，这两个领域是 P30 的基础卓越中心，针对阿片类药物使用障碍和 PET 成像开发新策略大脑功能的研究。拟议中心的名称是 Penn PET Addiction Center of 卓越奖（Penn PACE），代表放射科之间的合作努力和宾夕法尼亚大学的精神病学。此修订后的申请的一个重要补充是将耶鲁大学纳入这个P30中心。该中心最初将重点关注阿片类药物敏感性、成瘾性和阿片类药物受体的研究自杀，以及氧化应激和神经炎症在 OUD 中的作用。该中心利用宾夕法尼亚大学和耶鲁大学拥有独特的资源。中心PI 是 Robert H. Mach 博士，Britton Chance 放射学教授，Henry Kranzler 博士，本杰明 Rush 精神病学教授和 Caryn Lerman 博士（John Glick 精神病学副教授）宾夕法尼亚大学战略计划院长。另一位关键人物是耶鲁大学的理查德·卡森博士 PET中心；卡森博士将领导耶鲁大学的研究工作并指导数据分析成像核心的组成部分。他还与 David Mankoff 博士共同担任影像核心部门的联合主任在宾夕法尼亚大学。该中心由一个行政核心和三个研究核心组成：放射化学、影像和临床核心。该中心的核心是试点项目核心，它由一组由 NIDA 资助的研究人员利用所提供的机会确定和潜在的试点项目通过这个 P30 核心卓越中心计划来扩展他们的研究项目。我们预计宾夕法尼亚大学 PACE 将使我们对神经生物学机制的理解取得重大进展阿片类药物使用障碍和神经炎症的治疗只能通过以下方法的结合才能实现：严格控制的临床试验加上 PET 提供的独特分子成像特性。