Infrastructure for Pathways, a Prospective Study of Breast Cancer Survivorship

通路基础设施，乳腺癌存活率的前瞻性研究

基本信息

批准号：
10622554
负责人：
Christine B. Ambrosone
金额：
$ 103.61万
依托单位：
KAISER FOUNDATION RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-01 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10622554
关键词：
Accident and Emergency department Address African American Air Aliquot Alternative Therapies Ambulatory Surgical Procedures Ancillary Study Asian Behavior Biological Assay Biological Specimen Banks Blood Blood specimen Breast Cancer Treatment Breast Cancer survivorship California Cancer Prognosis Cardiovascular Diseases Cementation Cessation of life Characteristics Clinical Cohort Studies Communication Communities Complement Complementary therapies Comprehensive Cancer Center DNA DNA Microarray Chip Data Data Linkages Databases Diagnosis Diagnostic Dimensions Dose Eating Electronic Health Record Emergency department visit Enrollment Environment Environmental Exposure Epidemiology Event Formalin Genetic Health Healthcare Healthcare Systems Hereditary Disease Hospitalization Infrastructure Infrastructure Activities Institution Integrated Health Care Systems Latina Life Style Link Management Information Systems Measures Medical Molecular Neighborhoods Operative Surgical Procedures Outcome Paraffin Embedding Participant Pathologic Pathway interactions Patient Self-Report Patients Pharmaceutical Preparations Physical activity Plasma Prospective Studies Prospective, cohort study Quality of life Questionnaires Recurrence Reporting Research Research Personnel Research Priority Research Project Grants Research Support Resources Saliva Serum Slide Social Environment Social Network Social support Specimen Time Tissue Microarray Toxic effect Treatment Protocols Tumor Bank United States National Institutes of Health Update Whole Blood Woman biobank bone health breast cancer diagnosis built environment cancer care cancer invasiveness cancer therapy care systems chemotherapy cohort comorbidity cost data enclave data resource design dietary supplements epidemiology study ethnic diversity experience follow-up genome-wide health care service utilization health plan improved innovation lifestyle factors malignant breast neoplasm member multi-ethnic patient-clinician communication programs racial diversity saliva sample tumor virtual water quality web portal

项目摘要

ABSTRACT The Pathways Study is a prospective cohort study of women diagnosed with first primary invasive breast cancer in the Kaiser Permanente Northern California (KPNC) health care system. Enrolled from January 2006 through May 2013, the 4,505 women in the cohort are racially and ethnically diverse, and include 351 (7.8%) African American, 512 (11.4%) Latina, and 599 (13.3%) Asian women. Data have been collected on food intake, physical activity, use of nutritional supplements and complementary and alternative therapies, and quality of life, social support, doctor-patient communications, and other factors. We have banked biospecimens at Roswell Park Comprehensive Cancer Center including blood (n=4,034, or 90% of the cohort), saliva (n=4,310, or 96%), and extracted germline DNA (n=4,437, or 99%), and have conducted genome-wide assays through the NIH Center for Inherited Disease Research program. We have established a biorepository of slides and tumor blocks from initial surgery (n=4,150, or 92%). We have also geocoded baseline addresses and linked these data to contextual databases to create neighborhood-level social and built environment variables. The KPNC setting provides access to electronic health records (EHRs), and we have detailed data available on diagnostic characteristics, treatment regimens, high-grade toxicities, and comorbid conditions. As of February 24, 2020, 572 recurrences, 424 second primary invasive cancers, and 886 deaths have been identified, with 1,286 women with at least one of these outcomes. In this infrastructure competitive renewal application, we propose to maintain and augment the Pathways Study to support research questions that build upon this resource. Study participants will continue to be followed for updates and outcomes through biennial follow-up questionnaires. We will maintain our biorepositories at Roswell Park and KPNC, and expand our tumor specimen bank by collecting slides and tumor blocks from ~600 recurrences. We will enhance our data resources with ongoing linkage with the KPNC EHR, and establish new linkages with geospatial environmental exposure databases and California statewide data on hospitalizations, emergency department visits, and ambulatory surgery. To address relevance to changes in breast cancer treatment and care, we will complement the cohort by establishing a data-only cohort of about 48,000 invasive breast cancer cases diagnosed and treated in KPNC from 2006-2023, will extract data from the KPNC EHR, and link to geospatial and statewide health care data, as with the Pathways Study. We will continue engagement with our External Advisory Board and Community Advisory Board to help guide infrastructure activities and prioritize research use of this cohort. We will also create a Pathways Study data enclave that will enable investigators to readily explore data and biospecimen availability for analyses or research projects. Continued support will enhance this unique, outstanding, multi-level, multi-dimensional, innovative resource, and facilitate its availability for the broader research community.

抽象的途径研究是一项前瞻性队列研究，对被诊断为初次浸润性乳房的妇女 Kaiser Permanente北加州（KPNC）医疗保健系统中的癌症。从2006年1月开始注册到2013年5月，该队列中的4,505名妇女在种族和种族上都是多样的，其中包括351（7.8％）非洲裔美国人，512（11.4％）拉丁裔和599（13.3％）亚洲妇女。已经收集了有关食物摄入，体育锻炼，营养补充剂的使用以及互补和替代疗法以及生活质量，社会支持，医生交流，和其他因素。我们已经在罗斯威尔公园综合癌症中心进行了生物测量血液（n = 4,034，或同类的90％），唾液（n = 4,310或96％）和提取的种系DNA（n = 4,437，或 99％），并通过NIH遗传疾病研究中心进行了全基因组测定程序。我们已经从初始手术开始建立了幻灯片和肿瘤块的生物座（n = 4,150或 92％）。我们还将地理编码的基线地址链接到上下文数据库以创建邻里级别的社会和建筑环境变量。 KPNC设置可访问电子健康记录（EHR），我们拥有有关诊断特征，治疗方案的详细数据，高级毒性和合并条件。截至2020年2月24日，第572次复发，424秒侵入性癌症和886例死亡已被发现，其中1,286名妇女至少有其中一名。在此基础设施竞争性更新应用中，我们建议维护和扩大路径支持以此资源为基础的研究问题。学习参与者将继续紧随其后的是通过两年一次的后续问卷进行更新和结果。我们将维护我们的 Roswell Park和KPNC的生物库，并通过收集幻灯片和大约600次复发的肿瘤阻滞。我们将通过与KPNC进行持续的联系来增强我们的数据资源 EHR，并与地理空间环境曝光数据库建立新的联系和全州加利福尼亚有关住院，急诊科和门诊手术的数据。解决与乳腺癌治疗和护理的变化，我们将通过建立仅数据队列来补充队列从2006 - 2023年开始，在KPNC中诊断和治疗的大约48,000例侵入性乳腺癌病例将提取与途径研究一样，来自KPNC EHR的数据以及与地理空间和全州医疗保健数据链接的数据。我们将继续与我们的外部顾问委员会和社区咨询委员会互动以帮助指导基础设施活动并优先考虑该队列的研究使用。我们还将创建一个途径研究数据飞地将使调查人员容易探索数据和生物测量的可用性，以进行分析或研究项目。持续的支持将增强这种独特的，杰出的，多级的，多维的，创新资源，并促进其对更广泛的研究社区的可用性。

项目成果

期刊论文数量（38）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Development of cardiometabolic risk factors following endocrine therapy in women with breast cancer.

乳腺癌女性内分泌治疗后心脏代谢危险因素的发展。

DOI：
10.21203/rs.3.rs-2675372/v1
发表时间：
2023
期刊：
Research square
影响因子：
0
作者：
Rillamas-Sun,Eileen;Kwan,MarilynL;Carlos,California;Cheng,Richard;Neugebauer,Romain;Rana,JamalS;Nguyen-Huynh,Mai;Shi,Zaixing;Laurent,CecileA;Lee,ValerieS;Roh,JaniseM;Huang,Yuhan;Shen,Hanjie;Hershman,DawnL;Kushi,Lawrence
通讯作者：
Kushi,Lawrence

Associations of Post-Diagnosis Lifestyle with Prognosis in Women with Invasive Breast Cancer.

诊断后生活方式与浸润性乳腺癌女性预后的关系。

DOI：
10.1158/1055-9965.epi-22-1274
发表时间：
2023
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
0
作者：
Troeschel,AlyssaN;Hartman,TerrylJ;McCullough,LaurenE;Ergas,IsaacJ;Collin,LindsayJ;Kwan,MarilynL;Ambrosone,ChristineB;Flanders,WDana;Bradshaw,PatrickT;CespedesFeliciano,ElizabethM;Roh,JaniseM;Wang,Ying;Valice,Emily;Kus
通讯作者：
Kus

"I Had to Make Them Feel at Ease": Narrative Accounts of How Women With Breast Cancer Navigate Social Support.

DOI：
10.1177/1049732321989999
发表时间：
2021-05
期刊：
Qualitative health research
影响因子：
3.2
作者：
Wright JD;Kroenke CH;Kwan ML;Kushi LH
通讯作者：
Kushi LH

Individual- and neighborhood-level socioeconomic status and risk of aggressive breast cancer subtypes in a pooled cohort of women from Kaiser Permanente Northern California.

DOI：
10.1002/cncr.33861
发表时间：
2021-12-15
期刊：
Cancer
影响因子：
6.2
作者：
Aoki RF;Uong SP;Gomez SL;Alexeeff SE;Caan BJ;Kushi LH;Torres JM;Guan A;Canchola AJ;Morey BN;Lin K;Kroenke CH
通讯作者：
Kroenke CH

Changes in bone mineral density in women with breast cancer receiving aromatase inhibitor therapy.