Severity and long-term health effects of COVID-19 among World Trade Center responders

COVID-19 对世贸中心急救人员的严重程度和长期健康影响

• 批准号: 10620252
• 负责人: BENJAMIN J LUFT
• 金额: $ 58.51万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620252
• 关键词: Severity; long; term; health; effects

PROJECT SUMMARY / ABSTRACT Since late 2019, SARS-CoV-2 virus, and a resulting, potentially deadly disease called COVID-19, have caused a global pandemic. SARS-CoV-2 primarily causes disease in lungs but can also cause gastrointestinal and neurological disease. The majority of SARS-CoV-2 infections are mild, however people of older age and people with certain pre-existing conditions are at increased risk of severe illness and death. Emerging evidence suggests that genetic factors may also contribute to COVID-19 severity. While most infections completely resolve within several weeks, some people continue experiencing COVID-19 symptoms for weeks or even months after recovering from acute illness. Of major concern is an emerging evidence that even those who recover from symptomatic COVID-19 and even those who had a mild disease, may experience serious long-term complications affecting different body organs. Some of these complications include respiratory, cardiovascular, renal, neurological, and psychiatric conditions. Importantly, many potential long-term effects of COVID-19, as well as risk factors for long-term complications, remain unknown. Men and women who worked as first responders during the tragic 9/11/2001 World Trade Center (WTC) events constitute an aging population. Toxic exposures at the WTC sites caused a disproportionally high prevalence of certain health conditions (designated as WTC-related conditions) in this population, many of which have either been identified or are hypothesized to be risk factors for severe COVID-19 disease and may increase the likelihood of developing long-term complications. New York City (NYC) area, including Long Island, suffered from a major early SARS-CoV-2 outbreak, with an estimated 19-23% of the general population being infected in NYC. Pilot data from Long Island WTC Health Program suggest that about 10% of WTC responders in this area may have been infected. This research project aims to: 1) Assess the impact of SARS-CoV-2 infection, COVID-19 disease, and mandatory social distancing measures on short- and long-term physical and mental health outcomes among WTC responders; 2) Investigate demographic, health, and occupational risk factors, as well as the impact of toxic WTC exposures on COVID-19 disease severity and negative health outcomes following SARS-CoV-2 infection, and 3) Investigate genetic risk factors for COVID-19 disease severity and negative post-COVID outcomes. We hypothesize that in this population SARS-CoV-2 infection will exacerbate incidence and progression of respiratory, cardiovascular, and mental health conditions, and that similar demographic, health, genetic, occupational, and toxic exposure factors will be associated with increased risk of severe disease and long-term complications. The results of this study will help to better understand the impact of COVID-19 on WTC responders, identify sub-populations at increased risk of negative outcomes, and inform targeted interventions to manage these risks. Some of the study findings, in particular occupational and genetic risk factors of negative COVID-19 outcomes, will have broader implications beyond WTC responder population.

项目摘要 /摘要 自2019年底以来，SARS-COV-2病毒以及一种称为Covid-19的潜在致命疾病已引起 全球大流行。 SARS-COV-2主要引起肺部疾病，但也可能引起胃肠道和 神经疾病。大多数SARS-COV-2感染是温和的，但是年龄较大的人和人们 在某些先前存在的条件下，患严重疾病和死亡的风险增加。新兴证据表明 该遗传因素也可能导致19.19的严重程度。虽然大多数感染完全解决了 几个星期，有些人继续经历了199症状，几周甚至几个月后 从急性疾病中康复。主要关注的是一个新兴的证据，即使那些从 有症状的Covid-19，甚至患有轻度疾病的人，可能会遇到严重的长期并发症 影响不同的身体器官。其中一些并发症包括呼吸道，心血管，肾脏， 神经和精神病疾病。重要的是，Covid-19以及 长期并发症的危险因素仍然未知。 在2001年9月11日世界贸易中心（WTC）活动期间担任第一响应者的男性和女人 构成老龄化的人口。 WTC站点的有毒暴露导致不成比例的患病率 该人群中的某些健康状况（指定为WTC相关条件），其中许多都有 被鉴定或被认为是严重Covid-19疾病的危险因素，并可能增加可能性 发展长期并发症。包括长岛在内的纽约市（纽约市）地区 早期的SARS-COV-2爆发，估计有19-23％的普通人群在纽约市感染。飞行员 长岛WTC健康计划的数据表明，该领域约有10％的WTC响应者可能有 被感染。该研究项目的目的是：1）评估SARS-COV-2感染，Covid-19疾病的影响， 以及对短期和长期心理健康成果的强制性社会疏远措施 WTC响应者； 2）调查人口统计，健康和职业危险因素，以及有毒的影响 SARS-COV-2感染后，WTC暴露于Covid-19疾病严重程度和负面健康结果， 3）研究COVID-19的遗传危险因素，疾病严重程度和后循环后结果负面。我们 假设在这个人群中，SARS-COV-2感染会加剧发生率和进展 呼吸道，心血管和心理健康状况，以及类似的人口，健康，遗传， 职业和有毒暴露因素将与严重疾病的风险增加有关 并发症。这项研究的结果将有助于更好地了解Covid-19对WTC的影响 响应者，确定以增加负面结果风险的子选集，并告知目标干预措施 管理这些风险。一些研究发现，特别是负面的职业和遗传危险因素 COVID-19的结果将在WTC响应者人群以外具有更广泛的含义。