Leveraging Community-Academic Partnerships and Social Networks to Disseminate Vaccine-Related Information and Increase Vaccine Uptake Among Black Individuals with Rheumatic Diseases

利用社区学术合作伙伴关系和社交网络传播疫苗相关信息并提高患有风湿病的黑人个体的疫苗接种率

• 批准号: 10620245
• 负责人: Candace Hillary Feldman
• 金额: $ 73.87万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-10 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620245
• 关键词: Address; Advocacy; Area; Arthritis; Assessment tool; Black Populations; Black race; Boston; COVID-19 pandemic; COVID-19 stress; COVID-19 vaccination; COVID-19 vaccine; Caring; Characteristics; Chicago; Chronic; Cities; Clinical Trials; Communicable Diseases; Communities; Critical Race Theory; Disease Outcome; Disease susceptibility; Disparity; Education; Educational Curriculum; Educational Intervention; Evaluation; Exhibits; Fright; General Population; Goals; Health; Immunocompromised Host; Individual; Infection; Information Dissemination; Intervention; Interview; Justice; Knowledge; Lupus; Maps; Methods; Modeling; Outcome; Patients; Persons; Pharmaceutical Preparations; Physicians; Play; Population; Positioning Attribute; Process; Public Health; Race; Randomized; Randomized, Controlled Trials; Recommendation; Regimen; Research; Rheumatism; Rheumatoid Arthritis; Rheumatology; Risk; Role; SARS-CoV-2 infection; Safety; Social Network; Societies; Structural Racism; Structure; Systemic Lupus Erythematosus; Testing; Training; Training Activity; Trust; Underrepresented Minority; Vaccinated; Vaccination; Vaccines; Work; acute care; adverse outcome; arm; black patient; comorbidity; density; design; empowerment; ethnic disparity; evidence base; experience; forging; health care availability; health care disparity; high risk; high risk population; immunosuppressed; improved; lens; long-standing disparities; low socioeconomic status; member; mortality; outreach; people of color; physically handicapped; racial disparity; racism; recruit; response; severe COVID-19; social health determinants; socioeconomic disparity; standard of care; transmission process; treatment arm; trial enrollment; uptake; vaccine acceptance; vaccine efficacy; vaccine hesitancy; vaccine response; vaccine safety; virtual

PROJECT SUMMARY Individuals with chronic rheumatic diseases including arthritis comprise approximately 25% of the U.S. population. Racial/ethnic and socioeconomic disparities in adverse, often avoidable outcomes occur in nearly all rheumatic diseases particularly among Black and lower socioeconomic status individuals. Despite the importance of vaccinations in patients with rheumatic diseases, and the high rates of serious infections, vaccine uptake is consistently poor. In the U.S., COVID-19 vaccine uptake is lower and vaccine hesitancy higher among Black patients compared with White patients, and this holds true in rheumatic diseases. With the profound disparities uncovered by the COVID-19 pandemic aggravated by proven disparities in rheumatic disease outcomes, and heightened vulnerability to infections, there is an urgent need to address low vaccine uptake and hesitancy among Black individuals with these conditions. In addition, it is critical to also increase vaccine uptake among the social networks of individuals with rheumatic diseases who are immunosuppressed and may have less robust vaccination responses. Our team has forged longstanding community-academic partnerships in the Boston and Chicago areas to understand the needs of Black individuals with lupus, a systemic rheumatic disease, and the role racism plays in health and healthcare access. Framed by the Public Health Critical Race Praxis that recognizes the pervasiveness of racism in our society, we will leverage our community-academic partnerships to implement the CDC's Popular Opinion Leader (POL) model whereby trusted community leaders are trained to disseminate information regarding COVID-19 vaccination through their social networks in predominately Black communities to increase vaccine uptake and reduce hesitancy. In response to the NOSI NOT-MD-21-008: Research to Address Vaccine Hesitancy, Uptake and Implementation among Populations that Experience Disparities, we propose the following aims: Aim 1. To leverage community- academic partnerships across two U.S. cities to develop training and evaluation materials for POLs. Aim 2a. To establish the efficacy of a community-based intervention with and without a racial justice framework to increase COVID-19 vaccine uptake and reduce hesitancy among social networks of Black individuals with rheumatic conditions. We will conduct a cluster randomized controlled trial to test whether POLs trained with racial justice framing embedded in information on vaccine safety and efficacy will result in greater COVID-19 vaccine uptake among their social network members compared to safety and efficacy training alone. Aim 2b. To determine the structure and composition of the outreach social networks of POLs. We will enhance the existing POL model by adding a validated mixed methods approach to compare the social networks reached by POLs in each arm. We hypothesize that incorporating a racial justice lens will empower POLs to disseminate information more broadly and more persuasively and increase vaccine uptake by reducing fear and mistrust.

项目摘要 包括关节炎在内的慢性风湿病患者占美国约25％ 人口。不利的种族/种族和社会经济差异，几乎可以避免的结果几乎发生 所有风湿性疾病，尤其是在黑人和较低的社会经济地位个人中。尽管有 风湿性疾病患者的疫苗接种重要性以及严重感染的高率 疫苗的摄取始终很差。在美国，Covid-19-19 与白人患者相比，黑人患者中的更高，这在风湿性疾病中是正确的。与 Covid-19发现的严重差异是风湿性差异的严重差异 疾病结局和增加感染的脆弱性，迫切需要解决低疫苗 有这些条件的黑人个人的吸收和犹豫。另外，也要增加至关重要 免疫抑制的风湿病患者的社交网络中的疫苗接种 并且可能具有较少的疫苗接种反应。我们的团队已经建立了长期的社区学术 波士顿和芝加哥地区的合作伙伴关系，以了解狼疮黑人的需求 系统性风湿病以及种族主义在健康和医疗保健方面的作用。由公众构建 健康关键的种族实践认识到社会中种族主义的普遍性，我们将利用我们的 社区学术合作伙伴关系，以实施CDC的流行意见领导者（POL）模型 受信任的社区领导者接受了培训，可以通过传播有关COVID-19的信息。 他们主要在黑人社区中的社交网络，以增加疫苗的吸收并减少犹豫。在 对NOSI NOT-MD-21-008的回应：解决疫苗犹豫，吸收和实施的研究 在经历差异的人群中，我们提出以下目的：目标1。利用社区 - 美国两个城市之间的学术合作伙伴关系，以开发POLS的培训和评估材料。目标2a。到 建立有或没有种族正义框架的基于社区干预的功效以增加 Covid-19-19 状况。我们将进行一项群集随机对照试验，以测试是否接受过种族正义训练的POLS 有关疫苗安全性和功效的信息嵌入的框架将导致更大的COVID-19疫苗吸收 与仅安全性和效力培训相比，他们的社交网络成员中的成员中。目标2B。确定 PON的外展社交网络的结构和组成。我们将增强现有的POL模型 通过添加一种经过验证的混合方法来比较POL在每个ARM中所达到的社交网络。 我们假设结合种族正义镜头将增强POLS以传播信息 通过减少恐惧和不信任，更广泛，更有说服力，增加疫苗的摄取。