Sensorimotor integration governing facial expression production in autism.

感觉运动整合控制自闭症患者的面部表情产生。

基本信息

批准号：
10899969
负责人：
Carissa J Cascio
金额：
$ 14.61万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-07 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10899969
关键词：
Animal Model Anxiety Architecture Attention Behavior Behavioral Bladder Brain Cardiac Characteristics Clinical Complex Computer Models Cues Development Emotional Endocrine system Environment Esthesia Evaluation Evoked Potentials Facial Expression Fascia Heart Heart Rate Human Immune system Impairment Individual Interoception Knowledge Lung Maintenance Measures Mediating Motivation Motor Pain Periodicity Physiological Play Process Production Psychiatry Reaction Recording of previous events Research Rest Role Safety Scanning Sensory Severities Signal Transduction Skin Sleep disturbances Social Behavior Social Interaction Stimulus Stream Subgroup Symptoms System Testing Uncertainty Viscera Visceral Vision Visual Visual Cortex Work autism spectrum disorder blood oxygen level dependent blood oxygenation level dependent response clinical diagnostics clinically relevant communication behavior comorbidity emotion regulation emotional experience emotional functioning experience heart rate variability improved indexing individuals with autism spectrum disorder insight interest multisensory neural neuroimaging pleasure potential biomarker repetitive behavior respiratory response sensory input sensory integration sensory stimulus social social deficits somatosensory theories visual stimulus

项目摘要

PROJECT SUMMARY Altered sensory experiences are prevalent in autism and have been implicated in not only the core behavioral characteristics of impaired social communication and repetitive behaviors, but in a range of associated comorbidities including sleep disturbances2 and anxiety24. Recent work in the sensory domain strongly suggests that the predictability, or lack thereof, of sensory stimuli heavily influences aberrant reactions and mediates relations between sensory sensitivity, anxiety, and social motivation in autism78-79. Most sensory research thus far has emphasized exteroceptive sensation—sensory signals that originate in the external environment—with less work on interoceptive sensation—sensory signals that arise from the viscera and skin to signal the brain about the physiological condition of the body6. These interoceptive cues are often the precursors of emotional experience, and thus have significant transdiagnostic clinical relevance in psychiatry. Evaluation of the emotional relevance of the external environment—within which social stimuli are embedded—requires a continuous exchange of information between exteroceptive and interoceptive processing streams. In other words, successful navigation of the social world depends on multisensory integration across the body boundary. Critically for autism, many visceral interoceptive signals tend to be very rhythmic (e.g., cardiac signals), and/or are under voluntary control (e.g., respiratory signals) and are thus far more predictable than environmental exteroceptive cues. This predictability is enhanced on average in individuals with autism, who tend to have higher heart rates and lower heart rate variability than controls. In the current project period, we found evidence for profoundly disrupted temporal integration of visceral interoceptive and exteroceptive signals, without clear evidence of disrupted interoception alone. We now propose, in this renewal, to isolate and test potential neural drivers and clinical sequelae of this disrupted integration. The proposed work will provide important new insights into the consequences of sensory processing deficits in autism that go beyond exteroceptive sensation, incorporating a sensory milieu that has high relevance for social-emotional functioning.

项目摘要改变的感觉经历在自闭症中普遍存在，不仅与核心有关社会沟通和重复行为受损的行为特征，但相关合并症，包括睡眠障碍2和动画24。感觉域中的最新工作强烈暗示感觉刺激的可预测性或缺乏可预测性会严重影响异常反应并调解自闭症中感觉敏感性，动画和社会动机之间的关系78-79。到目前为止外部环境 - 较少的在感知性感觉上的工作 - 内脏产生的感官信号和皮肤，向大脑发信号有关身体的身体状况6。这些互感的提示通常是情感体验的前体，因此具有显着的经诊断临床相关性精神病学。评估外部环境的情感相关性 - 在社会刺激的情况下嵌入式 - 要求扩展和跨性别之间的信息连续交换处理流。换句话说，社会世界的成功导航取决于多感官整个身体边界的集成。对自闭症的至关重要，许多内脏的互感信号往往是非常有节奏的（例如心脏信号）和/或受自愿控制（例如，呼吸信号），因此是比环境扩展提示更可预测。这种可预测性平均可增强患有自闭症的人，他们的心率较高，心率变异性较高，而不是对照。在当前的项目时期，我们发现了内脏互相暂时整合的严重破坏的证据和扩展的信号，没有明显的证据，仅仅拦截了拦截。我们现在建议更新，以分离和测试这种破坏整合的潜在神经元驱动因素和临床后遗症。拟议的工作将为感官处理缺陷的后果提供重要的新见解。自闭症超出了扩展的感觉，结合了与之相关的感官环境社会情感功能。

项目成果

期刊论文数量（17）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Disrupted integration of exteroceptive and interoceptive signaling in autism spectrum disorder.

自闭症谱系障碍中外感受和内感受信号的整合被破坏。

DOI：
10.1002/aur.1880
发表时间：
2018
期刊：
Autism research : official journal of the International Society for Autism Research
影响因子：
0
作者：
Noel,Jean-Paul;Lytle,Marisa;Cascio,Carissa;Wallace,MarkT
通讯作者：
Wallace,MarkT

Elevated Thresholds for Light Touch in Children With Autism Reflect More Conservative Perceptual Decision-Making Rather Than a Sensory Deficit.

自闭症儿童轻微触摸的阈值升高反映了更保守的知觉决策，而不是感觉缺陷。

DOI：
10.3389/fnhum.2020.00122
发表时间：
2020
期刊：
Frontiers in human neuroscience
影响因子：
2.9
作者：
Quinde-Zlibut,JenniferM;Okitondo,ChristianD;Williams,ZacharyJ;Weitlauf,Amy;Mash,LisaE;Heflin,BrynnaH;Woodward,NeilD;Cascio,CarissaJ
通讯作者：
Cascio,CarissaJ

Psychometric validation and refinement of the Interoception Sensory Questionnaire (ISQ) in adolescents and adults on the autism spectrum.

DOI：
10.1186/s13229-021-00440-y
发表时间：
2021-06-07
期刊：
Molecular autism
影响因子：
6.2
作者：
Suzman E;Williams ZJ;Feldman JI;Failla M;Cascio CJ;Wallace MT;Niarchou M;Sutcliffe JS;Wodka E;Woynaroski TG
通讯作者：
Woynaroski TG

Resting-State Functional Connectivity in Psychiatric Disorders.