Building a next-generation AMP-AIM Data Management Core to maximize FAIR-ness of autoimmune and immune-mediated disease research resources

构建下一代 AMP-AIM 数据管理核心，以最大限度地提高自身免疫和免疫介导疾病研究资源的公平性

• 批准号: 10900403
• 负责人: ANNA K GREENWOOD
• 金额: $ 50万
• 依托单位: SAGE BIONETWORKS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10900403
• 关键词: Acceleration; Address; Alzheimer' s Disease; Autoimmune; Autoimmune Diseases; Biological Assay; Biology; Cells; Communities; Complement; Computer software; Data; Data Coordinating Center; Data Set; Development; Disease; Documentation; Ecosystem; Engineering; Ensure; FAIR principles; Feedback; Funding; Goals; Grant; Image; Immune; Immune System Diseases; Individual; Inflammatory; Infrastructure; Investigation; Knowledge Portal; Link; Mediating; Medicine; Metadata; Modality; Modernization; Molecular; Multiomic Data; Pathway interactions; Persons; Phase; Phenotype; Positioning Attribute; Process; Psoriasis; Psoriatic Arthritis; Publications; Published Comment; Research; Research Personnel; Resource Sharing; Resources; Rheumatoid Arthritis; Sampling; Sjogren' s Syndrome; Specific qualifier value; Standardization; Structure; Subjects Selections; Surface; System; Systemic Lupus Erythematosus; Technology; Tissues; Update; Validation; Vision; Work; clinically relevant; cohort; data exploration; data management; data sharing; data standards; data structure; data warehouse; design; flexibility; high dimensionality; member; multiple omics; next generation; programs; tool; virtual

PROJECT SUMMARY/ABSTRACT The Accelerating Medicines Partnership Autoimmune and Immune-Mediated Diseases (AMP-AIM) program is developing a diverse array of multi-omic and imaging data to study multiple diseases, including rheumatoid arthritis, systemic lupus erythematosus, psoriasis, psoriatic arthritis, and Sjögren's disease, with an overarching goal to identify common inflammatory pathways and unique molecular underpinnings to these diseases. This proposal is designed to extend the work of the Accelerating Medicines Partnership Alzheimer's Disease (AMP- AD) Data Coordination Center (AD-DCC) grant (U24AG061340) to support the coordination and dissemination of resources of the AMP-AIM program. Specifically, this work aims to expand the access to and enable reuse of resources being developed in the AMP-AIM program by using the systems, processes, and technology developed in the AMP-AD program to both increase within consortia sharing and broader sharing with the research community. Due to similarity in data structure being between collected in the Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP-RA/SLE) program and the structure of data currently being hosted through the AMP-AD program, a supplement mechanism was used to provide rapid support of AMP- RA/SLE (U24AG061340-03S3). A second supplement project (U24AG061340-04S2) built on work done in the initial funding period to support the management of existing AMP-RA/SLE Phase I and Phase II resources by enabling upload of new Phase II data, expanding on features of the Autoimmune and Related Knowledge Portal (ARK Portal), and positioning the ARK Portal to accommodate requirements from the AMP-AIM program. This proposal aims to establish what we view as a “next-generation” AMP-AIM Data Management Core (DMC) to maximize FAIR-ness of autoimmune and immune-mediated disease research resources. We intend to achieve this vision by (1) evolving the AMP-AIM data sharing infrastructure while providing continued data management support to establish a standards-driven research ecosystem; and (2) enhancing ARK Portal resource dissemination to enable standards-powered discovery and reuse.

项目概要/摘要 加速药物合作伙伴自身免疫和免疫介导疾病 (AMP-AIM) 计划 开发多种多组学和成像数据来研究多种疾病，包括类风湿病 关节炎、系统性红斑狼疮、牛皮癣、牛皮癣、关节炎和干燥病， 目标是确定这些疾病的常见炎症途径和独特的分子基础。 该提案旨在扩展加速药物合作伙伴阿尔茨海默病 (AMP- AD）数据协调中心（AD-DCC）拨款（U24AG061340）以支持协调和传播 具体而言，这项工作旨在扩大对 AMP-AIM 计划资源的访问并实现重用。 AMP-AIM 计划中使用系统、流程和技术开发的资源 AMP-AD 计划中开发的内容既增加了联盟内的共享，又增加了与 研究社区。 由于加速药物合作伙伴关系类风湿病收集的数据结构相似 关节炎和系统性红斑狼疮 (AMP-RA/SLE) 计划和目前正在制定的数据结构 通过AMP-AD计划主办，利用补充机制为AMP-AD提供快速支持 RA/SLE (U24AG061340-03S3)。第二个补充项目 (U24AG061340-04S2) 基于 RA/SLE 中所做的工作。 初始资助期，用于支持现有 AMP-RA/SLE 第一阶段和第二阶段资源的管理 允许上传新的第二阶段数据，扩展自身免疫和相关知识门户的功能 （ARK Portal），并定位 ARK Portal 以满足 AMP-AIM 计划的要求。 该提案旨在建立我们所认为的“下一代”AMP-AIM 数据管理核心 (DMC) 最大限度地提高自身免疫和免疫介导疾病研究资源的公平性。 通过 (1) 发展 AMP-AIM 数据共享基础设施，同时提供持续的数据管理来实现这一愿景 支持建立标准驱动的研究生态系统；(2) 增强 ARK Portal 资源； 传播以实现标准驱动的发现和重用。