Balancing the Risk and Benefits of Rapid Weight Gain in Infancy

平衡婴儿期体重快速增加的风险和益处

• 批准号: 8325591
• 负责人: Mandy Brown Belfort
• 金额: $ 14.9万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8325591
• 关键词: 7 year old; 8 year old; Adult; Award; Benefits and Risks; Birth; Birth Weight; Blood Pressure; Body mass index; Boston; Cardiovascular system; Child; Childhood; Clinical; Cognition; Cognitive; Data; Decision Analysis; Development; Disease; Elements; Epidemiology; Equilibrium; Gestational Age; Goals; Growth; Guidelines; Health; Health Services Research; Hypertension; Infant; K-Series Research Career Programs; Life; Measures; Mentors; Mentorship; Modeling; Neonatology; Neurocognitive; Obesity; Outcome; Overweight; Parents; Pattern; Pediatric Hospitals; Pediatrics; Population; Pregnancy; Premature Infant; Prevalence; Prevention strategy; Primary Prevention; Research; Research Personnel; Resources; Risk; School-Age Population; Skinfold Thickness; Structure; Training; Weight Gain; Work; adverse outcome; career; cohort; follow-up; improved; infancy; instructor; medical schools; neurodevelopment; nutrition; patient oriented; premature; programs; prospective

DESCRIPTION (provided by applicant): Mandy Brown Belfort, MD MPH is a neonatologist at Children's Hospital Boston and Instructor of Pediatrics at Harvard Medical School. This application for a K23 mentored career development award combines structured mentorship and training with a detailed research plan. The overall goal of this proposal is to train Dr. Belfort for a career as an independent patient-oriented researcher focused on the long term outcomes of early-life growth and nutrition. In full term infants, rapid infant gain is associated with long-term risks, such as overweight and high blood pressure, but whether rapid weight gain is similarly harmful in preterm infants is unclear. Rapid weight gain may also be beneficial, for example to neurodevelopment in preterm infants; whether rapid weight gain benefits neurodevelopment in full term populations is poorly understood. A better understanding of the balance of risks and benefits associated with rapid infant weight gain in both full term and preterm populations would inform guidelines for optimal infant weight gain patterns in these populations. For this award, Dr. Belfort aims first to assess the adiposity-related risks and neurocognitive benefits at school age associated with infant weight gain in 2 large, established cohorts of full term and preterm infants. Dr. Belfort will then build a decision analytic model to estimate the optimal rate of weight gain for full term and preterm infants, balancing adiposity-related risks with neurocognitive benefits through adulthood. This research plan builds directly on Dr. Belfort's previous training in epidemiology and health services research and her clinical expertise in neonatology. Her findings will provide critical information regarding patterns of weight gain that optimize long term health in full term and preterm populations. Dr. Belfort's unique resources include a supportive, accomplished multi-disciplinary mentorship team; access to 2 large, established, longitudinal cohorts of full term and preterm children; and advanced coursework in epidemiology and decision analysis. The proposed award will enable Dr. Belfort to make a substantial scientific contribution and to develop her career as an independent investigator.

描述（由申请人提供）：Mandy Brown Belfort，医学博士、公共卫生硕士，是波士顿儿童医院的新生儿科医生和哈佛医学院儿科讲师。 K23 指导型职业发展奖的申请将结构化的指导和培训与详细的研究计划结合起来。该提案的总体目标是培训贝尔福特博士成为一名以患者为中心的独立研究人员，专注于生命早期生长和营养的长期结果。在足月婴儿中，婴儿快速体重增加与超重和高血压等长期风险相关，但体重快速增加是否对早产儿同样有害尚不清楚。体重快速增加也可能有益，例如有利于早产儿的神经发育；体重快速增加是否有益于足月人群的神经发育尚不清楚。更好地了解足月和早产人群中与婴儿体重快速增加相关的风险和益处的平衡，将为这些人群中最佳婴儿体重增加模式提供指导。为了获得该奖项，贝尔福特博士的目标首先是在 2 个大型足月儿和早产儿队列中评估与肥胖相关的风险以及与婴儿体重增加相关的学龄期神经认知益处。然后，贝尔福特博士将建立一个决策分析模型，以估计足月儿和早产儿的最佳体重增加率，平衡肥胖相关风险与成年期的神经认知益处。该研究计划直接建立在贝尔福特博士之前在流行病学和卫生服务研究方面的培训以及她在新生儿学方面的临床专业知识的基础上。她的研究结果将提供有关体重增加模式的关键信息，从而优化足月和早产人群的长期健康。贝尔福特博士的独特资源包括一支支持性的、卓有成效的多学科导师团队；获得 2 个大型、已建立的足月儿和早产儿纵向队列；以及流行病学和决策分析方面的高级课程。拟议的奖项将使贝尔福特博士能够做出重大的科学贡献，并发展她作为独立研究者的职业生涯。

项目成果

No difference in urinary iodine concentrations between Boston-area breastfed and formula-fed infants.

波士顿地区母乳喂养和配方奶喂养的婴儿的尿碘浓度没有差异。

• 发表时间: 2014-08
• 作者: Gordon, Joshua H;Leung, Angela M;Hale, Andrea R;Pearce, Elizabeth N;Braverman, Lewis E;He, Xuemei;Belfort, Mandy B;Nelson, Sara M;Brown, Rosalind S
• 通讯作者: Brown, Rosalind S

Health state preferences associated with weight status in children and adolescents.

健康状况偏好与儿童和青少年的体重状况相关。

• 发表时间: 2011
• 影响因子: 2.4
• 作者: Belfort, Mandy B;Zupancic, John A F;Riera, Katherine M;Turner, Jane H G;Prosser, Lisa A
• 通讯作者: Prosser, Lisa A

Parental preference and ability to participate in web-based developmental screening and surveillance: preliminary evidence for preterm infants after NICU discharge.

父母参与基于网络的发育筛查和监测的偏好和能力：新生儿重症监护病房出院后早产儿的初步证据。

• 发表时间: 2014-11
• 影响因子: 1.6
• 作者: Lakshmanan, Ashwini;Santo, Eilann;McCormick, Marie C;Belfort, Mandy
• 通讯作者: Belfort, Mandy

Low iodine content in the diets of hospitalized preterm infants.

住院早产儿饮食中的碘含量较低。

• 发表时间: 2012-04
• 作者: Belfort, Mandy B;Pearce, Elizabeth N;Braverman, Lewis E;He, Xuemei;Brown, Rosalind S
• 通讯作者: Brown, Rosalind S

Using parent questionnaires to assess neurodevelopment in former preterm infants: a validation study.

使用家长问卷评估前早产儿的神经发育：一项验证研究。

• 发表时间: 2013-03
• 影响因子: 2.8
• 作者: Belfort, Mandy B;Santo, Eilann;McCormick, Marie C
• 通讯作者: McCormick, Marie C