Interoception as a Novel Risk Factor for Suicidal Thoughts and Behaviors

内感受作为自杀想法和行为的新危险因素

• 批准号: 10750168
• 负责人: Azure Reid-Russell
• 金额: $ 3.39万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10750168
• 关键词: Adolescence; Adolescent; Adult; Area; Attention; Cause of Death; Clinical; Data Collection; Development; Ecological momentary assessment; Exhibits; Exposure to; Feeling suicidal; Goals; Hospitalization; Hospitals; Interoception; Intervention; Language; Learning; Link; Longevity; Measurement; Mediating; Mediator; Meta-Analysis; Methods; Modeling; Nature; Pathway interactions; Perception; Prevention; Process; Psychopathology; Psychophysiology; Public Health; Recording of previous events; Research; Risk; Risk Factors; Sampling; Severities; Statistical Methods; Statistical Models; Suicide; Suicide prevention; Surveys; Testing; Time; Training; United States; Work; aged; bodily sensation; directed attention; experience; high risk; high-risk adolescents; improved; innovation; insight; negative affect; novel; pediatric trauma; programs; psychologic; skills; statistics; suicidal adolescent; suicidal behavior; suicidal risk; suicide rate; traumatized children; years of life lost

Project Summary Suicide is a leading cause of death worldwide and the second leading cause of death for adolescents in the US. Despite advances in understanding of suicidal thoughts and behaviors and their treatment, the suicide rate has not decreased. One possible factor limiting progress in this area has been a lack of focus on understanding (and targeting) developmental mechanisms that may give rise to suicidal thoughts and behaviors. Interoception, the perception of internal bodily states, holds promise as a novel factor that may increase risk for suicide. Suicidal thoughts and behaviors center around inflicting harm to the body, yet surprisingly little work has tested whether and how disrupted interoceptive processes may contribute to risk for suicide. Given the centrality of the body in suicidal thoughts and behaviors and the unique interoceptive learning and processing that may occur during adolescence, altered interoceptive processing represents a novel risk factor that may advance understanding of suicidal thoughts and behaviors among adolescents. This proposal tests the associations between interoceptive processes and the occurrence of suicidal thoughts and behaviors. Eighty adolescents with and without suicidal thoughts and behaviors will undergo assessments of suicidal thoughts and behaviors, psychophysiological measurement of interoceptive processes, exposure to childhood trauma, and ecological momentary assessments of suicidal thoughts and behaviors and appraisals of body sensations. Aim 1 of this proposal is to test the association between perceptual interoceptive processes (i.e., interoceptive accuracy, sensitivity, and attention) and suicidal thoughts and behaviors. Aim 2 of this proposal is to test the association between appraisals and descriptions of body sensations and suicidal thoughts and behaviors. Aim 3 of this proposal is to test whether interoceptive processes are a potential mediator of the associations between childhood trauma and suicidal thoughts and behaviors. The proposed study’s greatest potential impacts are to use innovative strategies to study a novel potential risk factor for suicidal thoughts and behaviors, identify putative pathways that have clear translational value, and to potentially identify novel targets for intervention to treat suicidal thoughts and behaviors in adolescents.

项目摘要 自杀是全球死亡的主要原因，也是青少年的第二大主要原因 我们。尽管在理解自杀思想和行为及其待遇方面取得了进步，但自杀率 尚未改善。在这一领域的一个可能限制进展的因素是缺乏关注 理解（和针对性的）发展机制，可能导致自杀思想和 行为。拦截是对内部身体状态的感知，将有望作为一个新的因素，可能 增加自杀的风险。自杀的思想和行为围绕对身体造成伤害，但 令人惊讶的是，几乎没有测试的工作是否以及跨感受过程是否有助于造成风险 自杀。鉴于身体在自杀思想和行为中的中心性以及独特的互感 青少年期间可能发生的学习和处理，改变的跨性别处理代表 新的风险因素可能会推动青少年中对自杀思想和行为的理解。这 提案测试互感过程与自杀思想的发生之间的关联 行为。有或没有自杀思想和行为的八十名青少年将接受评估 自杀的思想和行为，心理生理学测量的跨感受过程，暴露于 童年创伤以及对自杀思想和行为和评估的生态瞬时评估 身体感觉。该提案的目标1是测试感知性际观察的关联 过程（即互感的准确性，敏感性和注意力）以及自杀的思想和行为。目标2 该建议是测试评估与身体感觉的描述之间的关联 思想和行为。该提案的目标3是测试感知过程是否潜在 童年创伤与自杀思想和行为之间关联的调解人。提议 研究的最大潜在影响是利用创新策略来研究一种新的潜在风险因素 自杀思想和行为，确定具有明显翻译价值的假定途径，并 潜在地确定了干预措施的新颖目标，以治疗青少年的自杀思想和行为。