Evaluating Velopharyngeal Function During Phonation in Children Utilizing Static MRI

利用静态 MRI 评估儿童发声期间的腭咽功能

• 批准号: 10750304
• 负责人: Taylor Snodgrass
• 金额: $ 3.78万
• 依托单位: EAST CAROLINA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-12-01 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10750304
• 关键词: 5 year old; Address; Adenoidal structure; Age; Air; Anatomy; Articulation; Asian; Asian population; Black Populations; Black race; Child; Childhood; Cleft Palate; Clinic; Clinical; Clinical Data; Contracts; Data; Databases; Decision Making; Goals; Image; Imaging Techniques; Individual; Investigation; Length; Literature; Magnetic Resonance Imaging; Measures; Morphology; Movement; Muscle; Muscle Contraction; National Institute of Dental and Craniofacial Research; Nose; Operative Surgical Procedures; Oral cavity; Outcome; Patients; Pattern; Pediatric Hospitals; Pharyngeal structure; Phonation; Physiology; Population; Production; Protocols documentation; Race; Recording of previous events; Reporting; Research; Research Personnel; Rest; Speech; Speech Intelligibility; Stretching; Structure; Techniques; Tissues; Velopharyngeal Insufficiency; Visualization; age group; aged; craniofacial; design; diagnostic tool; health care disparity; imaging modality; improved; innovation; palate repair; racial population; recruit

PROJECT SUMMARY/ABSTRACT Magnetic resonance imaging (MRI) has gained popularity as an imaging modality for children with a history of cleft palate and/or velopharyngeal insufficiency (VPI) because it is currently the only instrumental assessment technique that allows for direct visualization of velopharyngeal muscles and structures. Because MRI allows for direct visualization of velopharyngeal anatomy, it can be very helpful in surgical planning for children with velopharyngeal insufficiency; however, there are no data describing typical structure size and movement patterns of the velopharynx during phonation using the protocol many cleft and craniofacial centers use for MRI. The protocol many craniofacial clinics use consists of sustained phonation of /i/ (shows maximal contraction of the velopharynx during production of a vowel) and /s/ (shows maximal contraction of the velopharynx during production of a consonant). The goal of this study is to establish preliminary data among non-cleft subjects for sustained phonation of /i/ and /s/, as visualized on MRI. There is a critical need for normative data during sustained phonation of /i/ and /s/, and these norms should include consideration of an individual's race. Racial considerations are imperative because race can significantly impact velopharyngeal structure size at rest, and size of structures at rest impacts physiology for speech. This study will provide preliminary normative data to define typical anatomy and physiology of the velopharynx during these sustained phonation tasks across three racial groups: Asian, Black, and White. Such data can be used for comparison to children with a history of cleft palate and/or velopharyngeal insufficiency, given this same MRI protocol is used by many craniofacial centers. These normative findings will help researchers and clinicians gain a better understanding of the differences between typical and atypical velopharyngeal function and how race can impact typical velopharyngeal function for speech. To establish preliminary normative data in children without a history of cleft palate or velopharyngeal insufficiency, the current study proposes two aims to 1) define normal velar function during sustained phonation of /i/ and /s/, 2) examine normal levator veli palatini muscle contraction during sustained phonation of /i/ and /s/. This is innovative, as it will provide preliminary normative sustained phonation data, controlling for race, which can be used for direct comparison to the anatomy of patients with VPI. We plan to recruit 42 children without a history of cleft palate or VPI, all aged five (common age for VPI surgery), to complete the clinical velopharyngeal MRI protocol, including sustained /i/ and /s/.

项目摘要/摘要 磁共振成像（MRI）已成为具有历史史的儿童的成像方式 left裂和/或咽咽功能不全（VPI），因为它是目前唯一的仪器评估 允许直接可视化咽肌肉和结构的技术。因为MRI允许 直接可视化尾咽解剖学，它对患有儿童的外科手术计划非常有帮助 咽喉不足；但是，没有描述典型结构大小和运动模式的数据 使用协议，在发声过程中，许多裂缝和颅面中心用于MRI。这 协议许多颅面诊所的使用包括 / i /的持续发音（显示了最大的收缩 在生产元音期间的速咽）和 / s /（显示尾咽的最大收缩 产生辅音）。这项研究的目的是在非小腿受试者之间建立初步数据 在MRI上可视化的 /i /和 /s /的持续发音。在迫切需要规范数据的过程中 /i /和 /s /的持续发音，这些规范应包括对个人种族的考虑。种族 必须考虑考虑因素，因为种族可以显着影响静脉咽脑结构的大小，并且 静止的结构的大小会影响言语的生理。这项研究将提供初步的规范数据 在这些持续的发音任务期间定义了速溶性的典型解剖学和生理学 种族群体：亚洲，黑人和白人。此类数据可用于与具有left病史的儿童进行比较 鉴于许多颅面中心使用了相同的MRI方案，pa和/或咽咽功能不全。 这些规范性的发现将帮助研究人员和临床医生更好地了解差异 在典型和非典型尾咽功能以及种族如何影响典型咽咽功能之间 语音。在没有left裂或尾咽病史的儿童中建立初步的规范数据 当前的研究不足，提出了两个目的1）定义持续发音期间的正常绒毛功能 /i /and /s /，2）检查 /i /和 /s/。这是创新的，因为它将提供初步规范性的持续发音数据，控制种族， 可直接与VPI患者的解剖结构进行直接比较。我们计划招募42个孩子 没有left裂或VPI的病史 速咽MRI方案，包括持续 /I /和 /S /。