Evaluating Velopharyngeal Function During Phonation in Children Utilizing Static MRI

利用静态 MRI 评估儿童发声期间的腭咽功能

基本信息

批准号：
10750304
负责人：
Taylor Snodgrass
金额：
$ 3.78万
依托单位：
EAST CAROLINA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-12-01 至 2025-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10750304
关键词：
5 year old Address Adenoidal structure Age Air Anatomy Articulation Asian Asian population Black Populations Black race Child Childhood Cleft Palate Clinic Clinical Clinical Data Contracts Data Databases Decision Making Goals Image Imaging Techniques Individual Investigation Length Literature Magnetic Resonance Imaging Measures Morphology Movement Muscle Muscle Contraction National Institute of Dental and Craniofacial Research Nose Operative Surgical Procedures Oral cavity Outcome Patients Pattern Pediatric Hospitals Pharyngeal structure Phonation Physiology Population Production Protocols documentation Race Recording of previous events Reporting Research Research Personnel Rest Speech Speech Intelligibility Stretching Structure Techniques Tissues Velopharyngeal Insufficiency Visualization age group aged craniofacial design diagnostic tool health care disparity imaging modality improved innovation palate repair racial population recruit

项目摘要

PROJECT SUMMARY/ABSTRACT Magnetic resonance imaging (MRI) has gained popularity as an imaging modality for children with a history of cleft palate and/or velopharyngeal insufficiency (VPI) because it is currently the only instrumental assessment technique that allows for direct visualization of velopharyngeal muscles and structures. Because MRI allows for direct visualization of velopharyngeal anatomy, it can be very helpful in surgical planning for children with velopharyngeal insufficiency; however, there are no data describing typical structure size and movement patterns of the velopharynx during phonation using the protocol many cleft and craniofacial centers use for MRI. The protocol many craniofacial clinics use consists of sustained phonation of /i/ (shows maximal contraction of the velopharynx during production of a vowel) and /s/ (shows maximal contraction of the velopharynx during production of a consonant). The goal of this study is to establish preliminary data among non-cleft subjects for sustained phonation of /i/ and /s/, as visualized on MRI. There is a critical need for normative data during sustained phonation of /i/ and /s/, and these norms should include consideration of an individual's race. Racial considerations are imperative because race can significantly impact velopharyngeal structure size at rest, and size of structures at rest impacts physiology for speech. This study will provide preliminary normative data to define typical anatomy and physiology of the velopharynx during these sustained phonation tasks across three racial groups: Asian, Black, and White. Such data can be used for comparison to children with a history of cleft palate and/or velopharyngeal insufficiency, given this same MRI protocol is used by many craniofacial centers. These normative findings will help researchers and clinicians gain a better understanding of the differences between typical and atypical velopharyngeal function and how race can impact typical velopharyngeal function for speech. To establish preliminary normative data in children without a history of cleft palate or velopharyngeal insufficiency, the current study proposes two aims to 1) define normal velar function during sustained phonation of /i/ and /s/, 2) examine normal levator veli palatini muscle contraction during sustained phonation of /i/ and /s/. This is innovative, as it will provide preliminary normative sustained phonation data, controlling for race, which can be used for direct comparison to the anatomy of patients with VPI. We plan to recruit 42 children without a history of cleft palate or VPI, all aged five (common age for VPI surgery), to complete the clinical velopharyngeal MRI protocol, including sustained /i/ and /s/.

项目概要/摘要磁共振成像 (MRI) 作为一种针对有病史的儿童的成像方式而受到欢迎腭裂和/或腭咽闭合不全 (VPI)，因为它是目前唯一的仪器评估允许直接观察腭咽肌肉和结构的技术。因为 MRI 允许腭咽解剖结构的直接可视化，对于患有以下疾病的儿童的手术计划非常有帮助腭咽闭合不全；然而，没有数据描述典型的结构尺寸和运动模式使用许多裂隙和颅面中心用于 MRI 的协议，在发声期间观察腭咽部的情况。这许多颅面诊所使用的方案包括持续发声 /i/（显示颅骨最大收缩）发出元音时的腭咽部）和/s/（显示发音时腭咽部的最大收缩）辅音的产生）。本研究的目的是在非唇腭裂受试者中建立初步数据 MRI 上显示，持续发出 /i/ 和 /s/ 的声音。期间迫切需要规范数据持续发声 /i/ 和 /s/，这些规范应包括考虑个人的种族。种族考虑因素是必要的，因为种族会显着影响静息时的腭咽结构尺寸，并且静止时结构的大小会影响言语的生理学。本研究将为定义在三个持续发声任务期间腭咽的典型解剖学和生理学种族群体：亚洲人、黑人和白人。此类数据可用于与有唇腭裂病史的儿童进行比较鉴于许多颅面中心都使用相同的 MRI 方案，因此可能会出现腭和/或腭咽功能不全的情况。这些规范性发现将帮助研究人员和临床医生更好地理解差异典型和非典型腭咽功能之间以及种族如何影响典型腭咽功能用于演讲。建立无腭裂或腭咽裂病史儿童的初步规范数据由于不足，当前的研究提出了两个目标：1）定义持续发声期间的正常软腭功能 /i/ 和 /s/，2) 检查 /i/ 和 /i/ 持续发声期间的正常提腭大肌收缩 /s/。这是创新的，因为它将提供初步规范的持续发声数据，控制种族，可用于与 VPI 患者的解剖结构进行直接比较。我们计划招募42名儿童无腭裂或 VPI 病史，年龄均为五岁（VPI 手术的常见年龄），完成临床腭咽 MRI 方案，包括持续 /i/ 和 /s/。