Add Health Parent Study: A Biosocial Resource for the Study of Multigenerational Racial/Ethnic Disparities in Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD)

添加健康父母研究：用于研究阿尔茨海默病和阿尔茨海默病相关痴呆 (AD/ADRD) 中多代人种/民族差异的生物社会资源

• 批准号: 10745617
• 负责人: ERIC A. BOERWINKLE
• 金额: $ 319.77万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745617
• 关键词: Address; Adolescent; Adult; Adult Children; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Behavior; Behavioral; Biological; Biological Factors; Biosocial; Black race; Blood; Child; Cognition; Cognitive; Cognitive aging; Collection; Communities; Consent; DNA; DNA Methylation; Data; Data Collection; Databases; Development; Dimensions; Discrimination; Disparity; Documentation; Dryness; Economics; Education; Environment; Epigenetic Process; Ethnic Population; Etiology; Generations; Genes; Genetic Processes; Genomic Library; Genomics; Health; Hispanic; Impaired cognition; Interview; Investigation; Knowledge; Lateral; Link; Longitudinal Studies; Measurement; Measures; National Longitudinal Survey of Adolescent to Adult Health; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Parents; Participant; Patterns of Care; Phase; Population; Preventive; Process; Protocols documentation; Race; Reporting; Research; Research Personnel; Resource Sharing; Resources; Respondent; Risk; Role; SNP genotyping; Saliva; Sample Size; Sampling; Sampling Studies; Scientist; Specimen; Spottings; Spouses; Surveys; Time; Weight; aged; caregiving; cognitive function; cognitive testing; cohort; data resource; dementia risk; design; ethnic difference; ethnic disparity; experience; family caregiving; genomic data; health data; health economics; healthy aging; high risk; indexing; innovation; insight; instrument; intergenerational; member; middle age; multi-ethnic; novel; offspring; phase 1 study; phase 2 study; protective factors; racial difference; racial disparity; racial population; recruit; social; social stigma; socioeconomics; whole genome

Abstract Significant knowledge gaps exist regarding intergenerational dimensions of cognitive aging and risk for Alz- heimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD), and how these processes differ across race and ethnic groups. The proposed Add Health Parent Study (AHPS) Phase 2 is designed to ad- dress these gaps. AHPS is an ongoing study of social, behavioral, and biological factors influencing healthy aging and the development of AD/ADRD in a national sample of adults currently aged 58-90. Sample members are parents of the National Longitudinal Study of Adolescent to Adult Health (Add Health) cohort, initially inter- viewed in Add Health in early midlife (1994-95) before differential survival could contribute bias to sample rep- resentation. Phase 1 of AHPS (2015-17) collected longitudinal data on a random subsample of parents and their spouse/partners (S/P, N= 3001), the majority (73%) of whom were Non-Hispanic (NH) White. Phase 2 of AHPS will collect social, behavioral, and health data on all available NH Black and Hispanic parents (BHS sup- plement, N= 2,505), and cognitive assessments and DNA data on all AHPS Phase 1 and BHS sample parents and their current S/P (total N= 5,506). By adding NH Black and Hispanic parents, AHPS will be sufficiently sta- tistically powered to address, for the first time, measurement of health, social, and behavioral differences in AD/ADRD risk and protective factors across race/ethnic groups and socioeconomic strata. Combined data from AHPS Phases 1 and 2 will be linked with rich longitudinal data on original Add Health re- spondents to create and disseminate the first nationally representative multigenerational biosocial resource with cognitive, genomic, behavioral, and social data for the study of racial/ethnic disparities in cognitive aging and AD/ADRD risk. Cognition and genomic data will be harmonized across the two generations of parents and children for innovative analysis of intergenerational predictors of AD/ADRD; the role of genetic processes in AD/ADRD etiology; and intergenerational and lateral caregiving. Project specific aims are: 1a. Recruit and interview additional sample of 2,505 NH Black and Hispanic parents with the AHPS survey. 1b. Consent all 5,506 AHPS members for participation in AD/ADRD Assessment and DNA data collection. 2a. Collect DNA and conduct SNP genotyping and DNA methylation analysis on AHPS sample. 2b. Develop an intergenerational genomic database to advance an understanding of the gene-environment interplay in the etiology of AD/ADRD. 3a. Examine novel longitudinal and intergenerational social, health, and behavioral risk and preventive factors for AD/ADRD across racial/ethnic groups and social strata. 3b. Examine AHPS members’ caregiving experiences and the socioeconomic consequences of caregiving ex- periences related to AD/ADRD conditions or risks. 4. Document, disseminate, and promote use of AHPS data to the global scientific community.

抽象的 关于认知衰老的代际维度和alz-的风险存在很大的知识差距 海默氏病和阿尔茨海默氏病有关的痴呆症（AD/ADRD），这些过程如何不同 跨种族和种族。拟议的添加健康父母研究（AHPS）第2阶段旨在广告 打扮这些缝隙。 AHP是对影响健康的社会，行为和生物学因素的持续研究 在目前58-90岁的全国成年人样本中，老化和AD/ADRD的发展。样本成员 是全国青少年纵向研究成人健康（ADD健康）队列的父母，最初是 在中年早期（1994 - 95年）中，在差异生存之前对健康有偏见的偏见 - 怨恨。 AHPS（2015-17）的第1阶段收集了父母随机子样本的纵向数据， 他们的配偶/伴侣（S/P，n = 3001），其中大多数（73％）是非西班牙裔（NH）白人。第2阶段 AHP将收集所有可用的NH黑人和西班牙裔父母的社交，行为和健康数据（BHS SUP- PLEMENT，n = 2,505），以及所有AHPS 1和BHS样本父母的认知评估和DNA数据 及其当前的S/P（总n = 5,506）。通过添加NH Black和西班牙裔父母，AHP将足够sta- 第一次解决健康，社会和行为差异的第一次解决 跨种族/族裔群体和社会经济性Stratta的AD/ADRD风险和保护因素。 AHPS 1和2的合并数据将与原始添加健康重新添加的丰富纵向数据联系在一起 赞助商创建和传播第一个国家代表性的多代表生物社会资源 认知，基因组，行为和社会数据，用于研究认知衰老的种族/种族差异 和AD/ADRD风险。认知和基因组数据将在两代父母中进行协调， 对AD/ADRD的代际预测指标的创新分析的儿童；遗传过程在 AD/ADRD病因；以及代际和横向护理。项目特定目标是： 1a。在AHPS调查中，招募和采访了2,505 NH Black和西班牙裔父母的其他样本。 1B。同意所有5,506名AHP成员参加AD/ADRD评估和DNA数据收集。 2a。收集DNA并在AHP样品上进行SNP基因分型和DNA甲基化分析。 2b。开发代际基因组数据库，以提高对基因环境的理解 AD/ADRD病因的相互作用。 3a。检查新颖的纵向和代际社会，健康和行为风险以及预防因素 在种族/族裔群体和社会阶层之间进行广告/adrd。 3b。检查AHPS成员的护理经验以及护理的社会经济后果 与AD/ADRD条件或风险有关的时期。 4。文件，传播并促进向全球科学界使用AHP的数据。