Environmental Influences on Child Health Outcomes (ECHO) and Pregnancy in Ohio

俄亥俄州环境对儿童健康结果 (ECHO) 和怀孕的影响

• 批准号: 10746498
• 负责人: Sarah Keim
• 金额: $ 132.58万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10746498
• 关键词: 21 year old; Adult; American Heart Association; Anthropometry; Appalachian Region; Area; Behavior; Birth; Black race; Caring; Child; Child Behavior; Child Health; Childhood; Clinical; Collaborations; Communities; Complement; Conceptions; Continuous Glucose Monitor; Data; Data Collection; Data Element; Development; Dimensions; Disparate; Emotional; Enrollment; Ensure; Environmental Exposure; Ethnic Origin; Generations; Genes; Genetic; Genomic approach; Goals; Health; Health system; Immigrant; Impairment; Individual; Inequity; Infant Health; Investigation; Knowledge; Leadership; Life; Life Style; Long-Term Effects; Longitudinal Studies; Maternal Exposure; Maternal and Child Health; Measures; Mediating; Mediation; Mediator; Medical center; Methods; Molecular; Neonatal; Neurodevelopmental Impairment; Not Hispanic or Latino; Ohio; Outcome; Parents; Participant; Pathway interactions; Patients; Pattern; Pediatric Hospitals; Pennsylvania; Perinatal; Personal Satisfaction; Population; Population Heterogeneity; Postpartum Period; Poverty; Pregnancy; Pregnancy Outcome; Protocols documentation; Refugees; Research; Research Personnel; Role; Rural; Secure; Site; Surveys; Techniques; Time; Underserved Population; United States National Institutes of Health; Universities; West Virginia; Work; cardiovascular health; cohort; emerging adult; epidemiologic data; ethnic minority population; experience; follow-up; health data; high risk; improved; innovation; maternal risk; neurodevelopment; offspring; perinatal period; postnatal; pregnant; prenatal; programs; public health relevance; racial minority population; recruit; repository; social health determinants; suburb

PROJECT SUMMARY / ABSTRACT The goal of the ECHO Ohio Cohort Site at Nationwide Children’s Hospital and The Ohio State University Wexner Medical Center (NCH-OSUWMC) is to contribute to the ECHO Cohort by collecting and providing valuable data on a diverse and often underserved population of participating pregnant individuals, conceiving partners, and children who live in our region, so we can improve maternal and child health everywhere by better understanding how exposures prior to and during pregnancy impact childhood outcomes. Nearly 1/5 of Ohio’s children live in poverty. The rate is more than twice that for non-Hispanic Black children. Central Ohio is diverse with a rapidly growing immigrant population including the largest ethnic Nepali and 2nd largest Somali refugee populations in the U.S.; 1 in 6 Columbus children have an immigrant parent. The patients we serve live not only in urban, suburban, and rural central Ohio, but also within Appalachian portions of southeast Ohio, Pennsylvania, and West Virginia. The communities we serve are ranked poorly across multiple maternal and child health well-being indicators, underscoring a critical need to better understand environmental influences in the perinatal period that contribute to adverse child outcomes both locally and nationally. The NCH-OSUWMC health system is highly experienced in contributing to large multicenter NIH studies involving pregnant individuals and children and well- poised to contribute interdisciplinary leadership. We have maintained a large perinatal repository of clinical, survey, and rich biospecimen data from pregnant individuals, their partners, and their children for over a decade. Our research coordinators and investigators are highly experienced in recruiting both pregnant individuals and children for research investigations and securely and efficiently processing health data and biospecimens. Of note, our track record in retaining diverse subpopulations of high-risk maternal/child dyads, as well as conceiving partners, for follow-up is strong. We provide specific expertise in evaluating lifestyle exposures in pregnancy, most prominently in maternal cardiovascular health, and outcomes expertise in pre-, peri-, and postnatal health and childhood neurodevelopment. We propose 1) evaluating the impact of maternal cardiovascular health during pregnancy using the American Heart Association Life’s Essential 8 framework on child socioemotional development and behavior to age 21, using existing ECHO Cohort Protocol core data elements and 2) investigating, using innovative methods (continuous glucose monitoring), the association between evolving maternal dysglycemia patterns across the peripartum period and child socioemotional development and behavior while evaluating neonatal anthropometrics as potential mediators. We propose to evaluate the interaction between genes and lifestyle exposures on socioemotional development via an association study complemented with imputed -omics data. In a preconception-focused aim, we propose examining the impact of maternal and paternal preconception cardiovascular health on socioemotional development and behavior. Our contributions to the ECHO cohort, providing diversity and expertise, will enhance knowledge leading to improved child health.

项目摘要 /摘要 全国儿童医院和俄亥俄州立大学Wexner的Echo Ohio队列网站的目标 医疗中心（NCH-OSUWMC）将通过收集和提供有价值的数据来为回声队列做出贡献 关于多样性，经常服务不足的参与孕妇，构想的伴侣，以及 居住在我们地区的孩子，因此我们可以通过更好的了解来改善各地的孕产妇和儿童健康 怀孕前后的暴露如何影响童年的结果。俄亥俄州近1/5的孩子居住 贫困。对于非西班牙裔黑人儿童来说，速度是两倍以上。俄亥俄州中部是潜水员 不断增长的移民人口，包括最大的尼泊尔民族和第二大索马里难民人口 美国；六分之一的哥伦布儿童有移民父母。我们服务的患者不仅在城市中生活 郊区和俄亥俄州中部的郊区，也在俄亥俄州东南部的阿巴拉契亚州，宾夕法尼亚州和 西弗吉尼亚州。在多个母校和儿童健康状况中，我们所服务的社区排名很差 指标，了解在围产期更好地了解环境影响的批判性需求 在当地和全国范围内为不利的儿童成果做出贡献。 NCH-OSUWMC卫生系统高度高 在为大型多中心NIH研究贡献涉及怀孕的个体和儿童以及良好的经验 被毒死以贡献跨学科的领导。我们维持了临床的大量围产期存储库 十多年来，调查以及来自孕妇，伴侣及其子女的丰富生物循环数据。 我们的研究协调员和研究人员在招募孕妇和 研究研究调查的儿童，并牢固有效地处理健康数据和生物测量。的 请注意，我们在保留高风险材料/儿童二元组的潜水员亚群体方面的记录以及构想 合作伙伴，跟进很强。我们提供特定的专业知识，以评估怀孕的生活方式暴露， 在母体心血管健康方面最突出，以及产前，杂期和产后健康方面的成果专业知识 和童年的神经发育。我们提出1）评估母体心血管健康期间的影响 使用美国心脏协会生活的儿童社会情感框架的怀孕框架 使用现有的Echo队列协议核心数据元素和2）的发展和行为21岁） 使用创新方法（连续葡萄糖监测）研究，不断发展的关联 跨期间期间和儿童社会情感发展和行为的产妇血糖模式 同时将新生儿人类术语作为潜在的介体。我们建议评估相互作用 通过协会研究完成的基因与生活方式发展的生活方式暴露 使用估算的 - 组数据。在以审前为重点的目的中，我们建议检查母亲和 父亲的先选对社会情感发展和行为的心血管健康。我们的贡献 对于提供多样性和专业知识的回声队列，将增强知识，从而改善儿童健康。