A Tailored mHealth Vaping Prevention Intervention for Adolescents with Congenital Heart Defects

针对先天性心脏病青少年的定制 mHealth 电子烟预防干预措施

基本信息

批准号：
10739666
负责人：
Kristen R. Fox
金额：
$ 18.74万
依托单位：
RESEARCH INST NATIONWIDE CHILDREN'S HOSP
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-15 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10739666
关键词：
3-Dimensional Acute Adherence Adolescent Adult Affect Age Area Behavior Therapy Behavioral Biological Markers Blood Pressure Cardiology Cardiovascular system Caring Characteristics Childhood Clinic Clinical Congenital Heart Defects Critical Congenital Heart Defects Data Development Plans Disease Educational Curriculum Effectiveness Electronic cigarette Feedback Fellowship Focus Groups Fred Hutchinson Cancer Research Center Future Goals Health Health Care Costs Health Status Health behavior and outcomes Healthcare High Prevalence Hypertension Individual Intervention Knowledge Longevity Managed Care Mentorship Methodology Modality Morbidity - disease rate Ohio Outcome Parents Participant Pediatric Hospitals Pediatric Research Personal Satisfaction Population Populations at Risk Predisposition Prevention Prevention education Prevention program Psychology Public Health Recording of previous events Reporting Research Research Institute Risk Risk Factors Science Scientist Self Management Survivors TNFSF15 gene Teenagers Time Tobacco Training Treatment Efficacy Universities Vulnerable Populations Youth acceptability and feasibility aged arm arterial stiffness cardiovascular health cardiovascular risk factor career career development cigarette smoking combustible cigarette design efficacy evaluation efficacy trial electronic cigarette use evidence base follow-up handheld mobile device information gathering intervention effect mHealth multidisciplinary perceived stress pilot trial preference prevent preventive intervention programs randomized, clinical trials recruit retention rate satisfaction social cognitive theory sociodemographics statistics stress management stress reduction tobacco prevention treatment arm treatment as usual usability vaping web page

项目摘要

PROJECT SUMMARY/ABSTRACT: Congenital heart defects (CHD) affect over 2.4 million individuals in the U.S and generate $6.1 billion in annual healthcare costs. Avoidance of tobacco is vital to mitigate CHD survivors’ risk for acquired cardiovascular complications, but the youth e-cigarette (“vaping”) crisis exposes the growing and vulnerable population of adolescents (“teens”) with CHD to potential vaping-related harms and significantly increases risk for conventional cigarette use. Interventions to prevent vaping among teens with CHD are critically needed, but no existing programs are sufficient for this at-risk group. Dr. Fox’s TL1 fellowship research showed that 31% of teens with CHD are susceptible to vaping and identified perceived stress and poor disease knowledge as potential risk factors, but existing programs do not address these considerations. The proposed research will generate and evaluate the first vaping prevention intervention tailored for teens with CHD. Aim 1: Adapt curriculum from an evidence-based, classroom-delivered vaping prevention intervention to include critical stress management and disease knowledge modules in a mobile Health (mHealth) format for teens (12-18 years) with CHD. Intervention adaptation/refinement will occur via: 1) focus groups with key stakeholders (teens with CHD, parents, cardiologists) to understand intervention preferences, and 2) a single-arm pilot trial of the adapted mHealth intervention (N=16) with follow-up focus groups to gather information for refinement. Aim 2: Evaluate the feasibility/acceptability of the mHealth intervention via a pilot randomized clinical trial (RCT; N=72). Exploratory Aim 3: Explore the preliminary efficacy of the mHealth intervention for indicators of vaping prevention (vaping-related efficacy, perceived vaping outcomes, e-cigarette knowledge). These aims directly align with Dr. Fox’s career goal of becoming an independent clinician-scientist with expertise in behavioral RCTs and scalable disease self-management interventions for transition-aged teens with CHD. To achieve this goal, Dr. Fox requires advanced training in the following areas: 1) behavioral intervention science to design and optimize interventions that can be implemented on a public health level, such as mHealth modalities, 2) RCT methodology and analysis to rigorously evaluate behavioral interventions for efficacy and effectiveness, and 3) CHD disease self- management and healthcare for transition-aged teens to incorporate unique factors of living with CHD into tailored interventions. The career development plan involves didactic and applied training and leverages expert multidisciplinary (public health, clinical/quantitative psychology, cardiology) mentorship from The Abigail Wexner Research Institute at Nationwide Children’s Hospital, one of the worlds’ fastest growing pediatric research centers, its academic affiliate The Ohio State University, and the Fred Hutchinson Cancer Research Center. This K23 proposal will provide high-quality preliminary data and instill expertise needed for an R01 efficacy trial, advancing toward the ultimate goal of enhancing wellbeing across the lifespan of CHD.

项目摘要/摘要：先天性心脏缺陷（CHD）影响超过240万人美国并产生61亿美元的年度医疗费用。避免烟草对于减轻冠心病至关重要幸存者发生心血管并发症的风险，但青年电子烟（“ vaping”）危机暴露了与毒品相关的危害和显着增加了常规香烟使用的风险。防止青少年烟的干预措施冠心病是至关重要的，但是对于这个高危人群，现有的计划不足以足够。福克斯博士的TL1 奖学金研究表明，有31％的冠心病青少年容易受到烟的影响和识别压力和疾病知识不足是潜在的危险因素，但现有计划并未解决这些问题考虑因素。拟议的研究将生成和评估第一次预防干预针对青少年量身定制的CHD。 AIM 1：调整基于循证的，教室的烟雾的课程预防干预措施，包括移动中的关键压力管理和疾病知识模块与CHD的青少年（12-18岁）的健康（MHealth）格式。干预适应/改进将通过以下方式进行：1）与主要利益相关者（与冠心病的青少年，父母，心脏病学家）一起了解干预的焦点小组偏好和2）适用于MHealth干预措施（n = 16）的单臂试点试验，随访重点小组收集信息进行改进。目标2：评估MHealth的可行性/可接受性通过试验随机临床试验（RCT; n = 72）进行干预。探索目的3：探索初步 MHealth干预效率对于预防烟雾的指标（与烟有关的效率，感知到蒸发结果，电子烟知识）。这些目标直接与福克斯博士的职业目标保持一致独立的临床科学家具有行为RCT和可扩展疾病自我管理方面的专业知识与CHD过渡时期青少年的干预措施。为了实现这一目标，福克斯博士需要高级培训以下领域：1）行为干预科学设计和优化可以是的干预措施在公共卫生层面上实施，例如MHealth模式，2）RCT方法论和分析严格评估行为干预措施的有效性和有效性，3）冠心病自我过渡时代青少年的管理和医疗保健将冠心病生活的独特因素纳入量身定制的干预措施。职业发展计划涉及教学和应用培训和利用专家多学科（公共卫生，临床/定量心理学，心脏病学）Abigail的精神训练全国儿童医院的韦克斯纳研究所，这是世界上增长最快的儿科之一研究中心，俄亥俄州立大学的学术会员和弗雷德·哈钦森癌症研究中心。该K23提案将提供R01所需的高质量初步数据和灌输专业知识功效试验，朝着在整个CHD寿命中增强健康的最终目标。