Neural Recording and Simulation Tools to Address the Mesoscale Gap

解决中尺度差距的神经记录和模拟工具

• 批准号: 10739544
• 负责人: John Compton Mosher
• 金额: $ 448.68万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10739544
• 关键词: Acceleration; Acute; Address; Aerosols; Amplifiers; Area; Auditory; Auditory area; Auditory system; Biological Models; Biophysics; Brain; Chronic; Classification; Clinical; Cochlea; Communities; Complex; Comprehension; Computer software; Data; Device or Instrument Development; Devices; Diagnosis; Diagnostic; Discrimination; Dura Mater; Elasticity; Elastomers; Electrodes; Electroencephalography; Electronics; Electrophysiology (science); Elements; Epilepsy; Evaluation; Film; Frequencies; Generations; Histologic; Human; Inferior Colliculus; Institution; Lateral; Lead; Length; Location; Longevity; Macaca; Maps; Measurement; Measures; Methods; Microelectrodes; Miniaturization; Modeling; Modification; Motor; Neurobiology; Neurosciences; Noise; Operative Surgical Procedures; Output; Pathology; Performance; Printing; Process; Publishing; Rattus; Resolution; Risk; Rodent; Signal Transduction; Site; Software Tools; Source; Speech; System; Technology; Testing; Thalamic structure; Thinness; Time; Utah; Validation; Work; auditory stimulus; biophysical model; brain computer interface; density; design; elastomeric; expectation; experimental study; flexibility; improved; in vivo; insight; manufacture; microelectronics; millimeter; multidisciplinary; neural; next generation; novel; novel strategies; open source; response; sensor; sensory system; simulation; software development; source localization; tool; virtual; voltage

Abstract We have designed a novel approach to perform multi-scale recordings in the brain across regions and depths. This tool, referred to as DISC for its directional and scalable sensing, is an array of microelectrodes surrounding the lead body and designed to maximize the phenomenon of “substrate shielding”. Electro-quasistatic modeling and in vivo data demonstrate significant improvements over microwires and ring electrodes, including (i) signal amplitude, (ii) signal-to-noise ratio, and (iii) source separation in classification testing. DISC measures local field potentials in stereo and with significant amplification, which is especially powerful in isolating sources at the mesoscale. Several critical challenges for the propagation of this technology are the inherent limitations in photolithographic manufacturing methods, and our continuing inability to relate the local field potential with detailed circuit function. To address these two challenges, we will develop a revolutionary manufacturing method for microelectronics based on aerosol jet printing (Aim 1) and develop a biophysical model that can predict specific voltage outputs (Aim 2). The amplification and directionality of DISC when combined with biophysical forward models will be a unique and power tool to improve the utility of the local field potential. The validation of the hardware and software tools will be performed using chronic rat and macaque auditory experiments. DISC will demonstrate both laminar and network-wide recordings in the auditory core during audio stimulation. We will analyze the ability of DISC recordings to discriminate the best frequency circuits and contrast this with a variety of virtual macroelectrodes, including the ring electrode currently used in sEEG. We believe this multidisciplinary work will culminate in 3 critical tools being made available to the neuroscience and clinical communities: (1) a stereotactically-guided depth array capable of chronic, low-noise wideband recordings that excel at high-resolution mesoscale information; (2) a detailed, multi-scale forward model (NetPyNE/Brainstorm pipeline) that produces simulated voltage readings specific to several device types including DISC; and (3) a high-resolution inverse model, which will extend source localization to mesoscale voltage inputs. The software development will be open-source.

抽象的 我们设计了一种新颖的方法，可以在跨区域和深度之间在大脑中执行多尺度记录。该工具被称为圆盘的方向性和可扩展传感器，是围绕铅体的一系列微电极，旨在最大化“底物屏蔽”现象。电质量建模和体内数据表现出对微小电极和环电极的显着改善，包括（i）信号放大器，（ii）信噪比和（iii）分类测试中的源分离。光盘测量立体声中的局部场电位，并具有显着的扩增，这在隔离中尺度的源中特别有力。该技术传播的几个关键挑战是光刻制造方法的继承局限性，以及我们继续无法将本地现场潜力与详细的电路功能联系起来。为了应对这两个挑战，我们将基于气溶胶喷射打印（AIM 1）开发一种革命性的微电子制造方法，并开发一个可以预测特定电压输出的生物物理模型（AIM 2）。与生物物理前向模型相结合时，光盘的扩增和方向性将是提高局部田间潜力效用的独特和电源工具。硬件和软件工具的验证将使用慢性大鼠和猕猴的听觉实验执行。光盘将在音频仿真期间在听觉核心中演示层流和网络范围的记录。我们将分析光盘记录区分最佳频率电路的能力，并将其与各种虚拟大型电极（包括当前在SeeG中使用的环电极）进行对比。我们认为，这项多学科工作将达到三种关键工具，可为神经科学和临床社区提供：（1）立体定位引导的深度阵列，能够具有慢性，低噪声宽带记录，可在高分辨率中尺度信息信息上表现出色； （2）一种详细的，多尺度的远期模型（Netpyne/头脑风暴管道），该模型会产生针对多种设备类型（包括光盘）的模拟电压读数； （3）高分辨率逆模型，该模型将将源定位扩展到中尺度电压输入。软件开发将是开源的。