Training in Cardiovascular Research

心血管研究培训

• 批准号: 10626716
• 负责人: Stavros George Drakos
• 金额: $ 46.16万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10626716
• 关键词: Cardiovascular system; Research; Training

PROJECT ABSTRACT Cardiovascular disease is the leading cause of death in the United States. There is an ongoing need to provide multidisciplinary training for physician and PhD investigators who will devote a significant component of their professional activity to understanding the pathophysiology and treatment of cardiovascular disease. This is the 7th renewal application for the University of Utah (UofU) Cardiovascular Research Training Program. Since its inception in 1984, this program has trained 113 individuals who have largely gone on to pursue research careers. During the last training period (2016-2020), this training grant supported 21 post-doctoral research trainees (5 MD/DOs, 16 PhDs) who all remain active at academic institutions. Our trainees have authored 218 publications, with an average of 2 first-author publications each. They have also received several grants and career development awards (e.g. NIH, American Heart Association, NSF, ACS). This program continues to build on our unique strengths in cardiovascular research at the UofU, spanning basic and mechanistic investigation across a range of model systems and translational studies in humans. This training program unifies the three major cardiovascular research centers at the UofU Health Sciences Center: The Nora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), the Division of Cardiovascular Medicine at the School of Medicine, and the Molecular Medicine Program (U2M2) at the Eccles Institute of Human Genetics. This training program spans 13 UofU departments and includes 54 well-funded faculty mentors who lead exciting and productive cardiovascular research programs. Each trainee will participate in a two-year training program that includes a research project with a multidisciplinary mentoring committee, didactic coursework, and professional development opportunities. With this renewal application, we continue to request support to prepare 8 postdoctoral trainees to be leaders in cardiovascular research. The next stage of the training program will utilize an expanded mentor pool and implement a dual-leadership structure by two cardiology physician- scientists (MPIs: Stavros Drakos, MD, PhD, and Robin Shaw, MD, PhD) whose interests span from basic biochemistry to clinical trials. This renewal occurs at a time with the UofU is increasing its already sizeable investment into cardiovascular research training. A $6M addition to the CVRTI is being constructed to increase the number of cardiovascular research laboratories in an institute already fully dedicated to cardiovascular research and training. Also there is a campus-wide Cardiovascular Strategic Plan being implemented to enhance cardiovascular research and care and the UofU. The next five years of the training program will leverage these new resources and opportunities at the UofU and represents a new era of interdisciplinary collaborative cardiovascular research at our institution.

项目摘要 心血管疾病是美国死亡的主要原因。持续不断 为医师和博士调查人员提供多学科培训，他们将致力于重要 他们专业活动的组成部分，以了解 心血管疾病。这是犹他大学（UOFU）心血管的第七次续签申请 研究培训计划。自1984年成立以来，该计划已经培训了113个人 在很大程度上继续从事研究职业。在最后一个培训期（2016-2020），这项培训补助金 支持21名博士后研究学员（5个MD/DOS，16位博士学位），他们都活跃于学术 机构。我们的受训者撰写了218个出版物，平均有2个第一专人出版物 每个。他们还获得了几项赠款和职业发展奖（例如NIH，美国心脏 协会，NSF，ACS）。该计划继续以我们在心血管中的独特优势为基础 UOFU的研究，跨越了一系列模型系统的基本和机械调查 人类的翻译研究。该培训计划统一了三个主要的心血管研究 UOFU健康科学中心的中心：Nora Eccles Harrison Harrison心血管研究和 培训研究所（CVRTI），医学院心血管医学部门， Eccles人类遗传学研究所的分子医学计划（U2M2）。这个培训计划 跨越13个UOFU部门，包括54位资金丰富的教师导师，他们领导了令人兴奋和富有成效的 心血管研究计划。每个学员将参加一项为期两年的培训计划，包括 由多学科指导委员会，教学课程和专业的研究项目 发展机会。通过此续订申请，我们继续请求支持8 博士后学员将成为心血管研究的领导者。培训计划的下一个阶段将 利用扩展的导师池并通过两个心脏病医师实施双重领导结构 科学家（MPI：Stavros Drakos，医学博士，博士学位和Robin Shaw，MD，PhD），他们的兴趣来自基本 临床试验的生物化学。这种续约一次发生在UOFU中，它已经增加了很大 投资心血管研究培训。 CVRTI的增加了600万美元 增加已经完全致力于的研究所的心血管研究实验室的数量 心血管研究和培训。还有一个范围内的心血管战略计划 实施以增强心血管研究和护理以及UOFU。接下来的培训五年 计划将利用UOFU的这些新资源和机会，代表 我们机构的跨学科协作心血管研究。

项目成果

Meningeal cells and glia establish a permissive environment for axon regeneration after spinal cord injury in newts.

• DOI: 10.1186/1749-8104-6-1
• 发表时间: 2011-01-04
• 期刊: Neural development
• 影响因子: 3.6
• 作者: Zukor KA;Kent DT;Odelberg SJ
• 通讯作者: Odelberg SJ

The small GTPase ARF6 stimulates β-catenin transcriptional activity during WNT5A-mediated melanoma invasion and metastasis.

• DOI: 10.1126/scisignal.2003398
• 发表时间: 2013-03-05
• 期刊: Science signaling
• 影响因子: 7.3
• 作者: Grossmann AH;Yoo JH;Clancy J;Sorensen LK;Sedgwick A;Tong Z;Ostanin K;Rogers A;Grossmann KF;Tripp SR;Thomas KR;D'Souza-Schorey C;Odelberg SJ;Li DY
• 通讯作者: Li DY

Canine Model of Ischemia-Induced Ventricular Tachycardia.

缺血引起的室性心动过速的犬模型。

• DOI: 10.1016/j.jss.2023.09.003
• 发表时间: 2024
• 期刊: The Journal of surgical research
• 作者: Hirahara,AnnieM;Khan,MuhammadS;Ishidoya,Yuki;Smego,Douglas;Roman,Orvelin;Ranjan,Ravi;Krueger,Lauren;Hoareau,Guillaume;Selzman,CraigH;Dosdall,DerekJ
• 通讯作者: Dosdall,DerekJ

Author Correction: Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment.

• DOI: 10.1038/s41467-022-31304-5
• 发表时间: 2022-06-20
• 期刊: Nature communications
• 影响因子: 16.6

Characterization of diffuse fibrosis in the failing human heart via diffusion tensor imaging and quantitative histological validation.

• DOI: 10.1002/nbm.3200
• 发表时间: 2014-11
• 期刊: NMR IN BIOMEDICINE
• 影响因子: 2.9
• 作者: Abdullah, Osama M.;Drakos, Stavros G.;Diakos, Nikolaos A.;Wever-Pinzon, Omar;Kfoury, Abdallah G.;Stehlik, Josef;Selzman, Craig H.;Reid, Bruce B.;Brunisholz, Kim;Verma, Divya Ratan;Myrick, Craig;Sachse, Frank B.;Li, Dean Y.;Hsu, Edward W.
• 通讯作者: Hsu, Edward W.