Signaling and Tumor Microenvironment (STME)

信号传导和肿瘤微环境 (STME)

• 批准号: 10627253
• 负责人: Marina Pasca Di Magliano
• 金额: $ 7.85万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627253
• 关键词: Achievement; Affect; Animal Model; Area; Award; Basic Science; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Control; Cells; Clinical Research; Collaborations; Community Outreach; Data Science; Detection; Development; Developmental Therapeutics Program; Diagnosis; Diagnostic; Doctor of Philosophy; Drug Kinetics; Drug Screening; Early Diagnosis; Epithelium; Faculty; Fibroblasts; Flow Cytometry; Funding; Future; Glossary; Goals; Grant; Growth; Hematopoiesis; Heterogeneity; Homeostasis; Immune; Immunity; Immunologic Monitoring; Immunology; Inflammation; Internal Medicine; Invaded; Journals; Knowledge; Malignant Neoplasms; Mentors; Metabolic; Metabolic Pathway; Metabolism; Metabolite Interaction; Michigan; Microbe; Molecular; Names; Neoplasm Metastasis; Operative Surgical Procedures; Pathway interactions; Peer Review; Phenotype; Physiology; Population Sciences; Prevention; Proteomics; Publications; Research; Research Personnel; Research Support; Resource Sharing; Role; Scheme; Schools; Seminal; Signal Transduction; Source; Structure; Therapeutic; Tissue imaging; Tissues; Training and Education; Transgenic Animals; Translating; Translational Research; United States National Institutes of Health; Universities; Work; cancer genetics; cancer prevention; cellular imaging; college; community engagement; extracellular; health communication; improved; insight; interdisciplinary collaboration; interest; irradiation; member; microbiome; molecular imaging; molecular pathology; neoplastic cell; novel; novel marker; pre-clinical; professor; programs; recruit; single cell analysis; small molecule; stemness; therapy resistant; treatment response; tumor; tumor initiation; tumor metabolism; tumor microenvironment; tumor progression; tumorigenesis; working group

PROJECT SUMMARY/ABSTRACT (SIGNALING AND TUMOR MICROENVIRONMENT) Members of the University of Michigan (U-M) Rogel Cancer Center (Rogel) Signaling and Tumor Microenvironment (STME) Program share interests that align with five of the nine Rogel cross-cutting research themes: Tumor Microenvironment & Metabolism; Molecular Determinants; Inflammation, Microbes & Immunity; Targets & Therapeutics; and Prevention & Early Detection. STME, formerly known as the Cancer Biology (CB), was renamed to reflect the areas of strength and focus of the membership. Members of the STME Program are engaged in understanding both tumor-intrinsic and microenvironmental effects of altered signaling networks. STME Program comprises 55 members from 28 departments and four schools at the University of Michigan. STME members have $15.3M in annual cancer-relevant grant funding (DC), 88% of which comes from peer- reviewed sources (36% NCI, 44% other NIH sources). Investigators are involved in intra- and inter-programmatic interactions and actively collaborate with Rogel Cancer Center researchers within the Basic Science, Translational and Clinical Research, and Cancer Control and Population Sciences Programs. During the period of 01/01/2017 and 12/31/2021, members authored a total of 910 cancer-relevant publications, 30.7% in journals with Impact Factors > 10. The shared research interests of program members are reflected in the program’s overall scientific aims: 1) Elucidate the role of cell fate and plasticity during tissue homeostasis and cancer progression, 2) Define the heterocellular interactions that drive tumor epithelial growth and treatment response, 3) Characterize metabolic and metabolite interactions that impact cancer and growth progression. The Aims will identify cell autonomous and microenvironmental factors that alter fundamental aspects of tumor initiation, expansion, invasion and metastasis. Our main goal is to translate the mechanistic findings to improve cancer prevention, diagnosis, and treatment.

项目摘要/摘要（信号和肿瘤微环境） 密歇根大学（U-M）Rogel癌症中心（Rogel）信号和肿瘤的成员 微环境（STME）计划分享了与九个Rogel横切研究中的五个保持一致的兴趣 主题：肿瘤微环境和代谢；分子决定因素；炎症，微生物和免疫力； 靶标和治疗学；以及预防和早期检测。 Stme，以前称为癌症生物学（CB）， 被更名为反映成员资格的力量和重点领域。 STME计划的成员是 参与了解改变信号网络的肿瘤内部和微环境效应。 STME计划由密歇根大学的28个系和4所学校组成55名成员。 STME成员的年度与癌症相关的赠款资金（DC）有1530万美元，其中88％来自同行 审查的来源（NCI 36％，其他NIH来源44％）。研究人员参与了媒介间和编程间 互动并与基础科学中的Rogel Cancer Center研究人员积极合作， 翻译和临床研究，以及癌症控制与人口科学计划。在此期间 在2017年1月1日和12/31/2021中，成员共同撰写了910个与癌症相关的出版物，期刊为30.7％ 影响因素> 10。计划成员的共同研究兴趣反映在该计划的 总体科学目的：1）阐明细胞命运和可塑性在组织稳态和癌症中的作用 进展，2）定义驱动肿瘤上皮生长和治疗反应的杂细胞相互作用， 3）表征影响癌症和生长进展的代谢和代谢产物相互作用。目的会 确定改变肿瘤起始基本方面的细胞自主和微环境因素， 扩展，入侵和转移。我们的主要目标是翻译机械发现以改善癌症 预防，诊断和治疗。