DIABETES PREVENTION / RISK / OMICS / METABOLISM / THERAPY (PROMT) INTERDISCIPLINARY TRAINING

糖尿病预防/风险/组学/代谢/治疗（PROMT）跨学科培训

• 批准号: 10627642
• 负责人: RAMA NATARAJAN
• 金额: $ 7.56万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627642
• 关键词: Diabetes prevention; Metabolism; Risk; Training

PROJECT SUMMARY/ABSTRACT Within the US, the incidence of diabetes is at epidemic proportions. At the same time, technological advancements are offering promising strategies to therapeutically ameliorate diabetes. The Arthur Riggs Diabetes & Metabolism Research Institute (AR-DMRI) at City of Hope (COH) is uniquely poised as a center of translational research excellence with a long-standing record of success in diabetes research. As such, the COH AR-DMRI has a profound commitment to training a diverse next generation of scientific leaders with the skills needed to develop novel technologies and translate them into the clinic. The internationally recognized experts Drs. Debbie Thurmond and Rama Natarajan formalized this commitment by bringing together research mentors from 3 themes: Prevention/Risk/Biomarkers/Omics, Metabolism, and Diabetes Therapy to create the (PROMT) Predoctoral T32 Training Program. The goal of the T32 program is to support outstanding predoctoral students with analytically intensive science education from diverse backgrounds with distinct perspectives to become scientific leaders in diabetes research in line with the NIDDK mission. The PROMT program will admit 2 predoctoral trainees/ year to participate in research across the translational science pipeline. PROMT will provide an unprecedented experience for predoctoral trainees and is predicted to strengthen their commitment to research careers that drive real change in clinical practice. Eligible candidates will be recruited through the Irell & Manella Graduate School of Biological Sciences (IMGS) at COH. After 2 years of IMGS core curriculum, PROMT students will commit to engage in PhD dissertation research and T32 program activities for 2 years. A 3rd year of PROMT training is available by competitive renewal. Trainees will select from among 16 Mentors and 17 Co-Mentors/Clinical Partners that comprise a collaborative group of faculties with a diverse array of interests from basic, translational to clinical science. Research interests of the mentors include islet biology, epigenetics, genomics and metabolomics, adipose and muscle metabolic dysregulation, and human islet transplantation, among others. Program highlights include robust institutional support (Years 1 and 2) and unique research resources on campus, including 3 GMP-compliant manufacturing facilities, and the Helford Clinical Research Hospital. The AR-DMRI is home to the NIDDK-sponsored Integrated Islet Distribution Program (IIDP) and the Human Islet Research Network (HIRN). The T32 curriculum focuses on diabetes and diabetes-related metabolic diseases, with an emphasis on responsible research conduct and reproducibility. Laboratory research, coursework, and translational research internships will be enhanced by regular institutional journal clubs, seminars, and symposia, and a yearly PROMT retreat. The PROMT structure includes an Executive Committee, Internal Advisory Board, External Advisory Board, Curriculum Committee, and Recruitment Committee. The AR- DMRI is in a period of rapid growth, adding new departments and top-level faculty and state-of-the-art facilities, and is pleased to welcome PROMT T32 students into our rigorous training environment.

项目概要/摘要 在美国，糖尿病的发病率已达到流行病的程度。同时，科技 进展为治疗改善糖尿病提供了有前景的策略。亚瑟·里格斯 希望之城 (COH) 的糖尿病与代谢研究所 (AR-DMRI) 拥有得天独厚的优势，成为糖尿病与代谢研究中心 卓越的转化研究，在糖尿病研究方面拥有长期的成功记录。因此，COH AR-DMRI 坚定致力于培养具有技能的多元化下一代科学领导者 需要开发新技术并将其转化为临床。国际公认的专家 博士。黛比·瑟蒙德 (Debbie Thurmond) 和拉玛·纳塔拉詹 (Rama Natarajan) 将研究导师聚集在一起，正式履行了这一承诺 从 3 个主题：预防/风险/生物标志物/组学、新陈代谢和糖尿病治疗来创建 (PROMT) 博士前T32培训计划。 T32计划的目标是支持优秀的博士前学生 通过来自不同背景和不同观点的分析强化科学教育，成为 糖尿病研究领域的科学领导者符合 NIDDK 的使命。 PROMT 计划将录取 2 名 博士前培训生/年参与整个转化科学管道的研究。 PROMT将提供 这对博士前学员来说是前所未有的体验，预计将加强他们的承诺 推动临床实践真正变革的研究职业。合格的候选人将通过 Irell 招募 ＆COH 的马内拉生物科学研究生院 (IMGS)。经过 2 年的 IMGS 核心课程后， PROMT 学生将承诺从事为期 2 年的博士论文研究和 T32 项目活动。一个 第三年的 PROMT 培训可通过竞争性更新获得。学员将从 16 名导师中选出 17 名共同导师/临床合作伙伴，由具有不同兴趣的院系组成的协作小组 从基础科学、转化科学到临床科学。导师的研究兴趣包括胰岛生物学、表观遗传学、 基因组学和代谢组学、脂肪和肌肉代谢失调以及人类胰岛移植， 除其他外。计划亮点包括强有力的机构支持（第一年和第二年）和独特的研究 校园资源，包括 3 个符合 GMP 要求的生产设施和 Helford 临床研究中心 医院。 AR-DMRI 是 NIDDK 赞助的综合胰岛分布计划 (IIDP) 和 人类胰岛研究网络（HIRN）。 T32课程重点关注糖尿病和糖尿病相关代谢 疾病，强调负责任的研究行为和可重复性。实验室研究， 定期的机构期刊俱乐部将加强课程作业和转化研究实习， 研讨会、座谈会以及每年一次的 PROMT 务虚会。 PROMT 结构包括执行委员会、 内部顾问委员会、外部顾问委员会、课程委员会和招聘委员会。 AR- DMRI 正处于快速发展时期，增加了新的院系、顶级师资和最先进的设施， 并很高兴欢迎 PROMT T32 学生加入我们严格的培训环境。