A handheld scanner for clinical oximetry

用于临床血氧测定的手持式扫描仪

• 批准号: 8353211
• 负责人: PERIANNAN KUPPUSAMY
• 金额: $ 18.33万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8353211
• 关键词: Americas; Amputation; Biological; Biopolymers; Blood flow; Body Regions; Calibration; Chronic; Clinical; Computer Simulation; Computer software; Custom; Development; Devices; Diagnostic; Diffusion; Dimensions; Disease; Electrodes; Electron Spin Resonance Spectroscopy; Elements; Encapsulated; Heating; Human Volunteers; Hyperbaric Therapy; Implant; Magnetism; Measurement; Measures; Methods; Modeling; Monitor; Neonatal Intensive Care; Operative Surgical Procedures; Oxygen; Oxygen saturation measurement; Penetration; Perfusion; Peripheral Vascular Diseases; Physiologic pulse; Polymers; Rattus; Reading; Reconstructive Surgical Procedures; Research Proposals; Sampling; Skin; Subcutaneous Tissue; Surface; Surgical Flaps; System; Techniques; Temperature; Testing; Time; Tissue Grafts; Tissues; Topical application; Transplantation; Ultrasonography; Validation; Weight; Work; Wound Healing; base; clinical application; clinically significant; design; design and construction; implantation; in vivo; instrument; instrumentation; interest; magnetic field; microwave electromagnetic radiation; minimally invasive; new technology; prototype; sensor; subcutaneous; success; tissue oxygenation; tool; wound

DESCRIPTION (provided by applicant): Measurement of transcutaneous oxygen perfusion through the skin is used clinically as a measure of blood flow to a region of the body, and serves as an indicative measure of wound healing potential. Topical oximetry may also be useful for tracking peripheral vascular disease (PVD). Currently, the only clinically-applied technique used for this purpose is transcutaneous oxygen monitoring (TCOM) using electrode based sensors, which require an active heating element to encourage diffusion of oxygen through the skin. Subcutaneous (2 - 3 mm below the skin surface) tissue oxygen measurements would be useful in determining blood flow in vascularized free tissue flaps used for reconstructive surgery or in tissues surrounding chronic wounds. Our group has demonstrated that biopolymer-encapsulated probes used in electron paramagnetic resonance (EPR) oximetry can be used for such applications when applied topically to the region of interest, or implanted below the skin. The use of EPR for such measurements is currently not feasible in a clinical setting due to the size, weight, and space restrictions presented by existing instrumentation. We therefore propose to design, build, and test a new, portable EPR system for clinical oximetry applications. The envisioned device will be similar to a clinical ultrasound unit, with a "wand" assembly that will be placed in contact with the skin to obtain oximetry measurements from the probe sensors placed on the body, or implanted just below the surface. We will use computer modeling to determine the optimum arrangement of magnets and resonator prior to construction of a working prototype device. We will then test and characterize the oxygen-sensitive probes to be used. We will then use the prototype device to quantify tissue oxygenation in a rat chronic wound model, and continue with validation measurements using the portable EPR unit on human volunteers to compare this new technology with the existing electrode-based TCOM. PUBLIC HEALTH RELEVANCE (provided by applicant): Diffusion of oxygen through the surface of the skin (transcutaneous oxygen diffusion) can be used as a diagnostic tool for a number of different diseases and conditions, including peripheral vascular disease (PVD). Subcutaneous tissue oxygen levels can be used as an indicator of wound healing potential or tissue graft transplant success. The objective of this proposal is to design and construct a new device which will permit accurate and rapid quantification of transcutaneous oxygen perfusion and subcutaneous (2 - 3 mm below the skin) oxygen levels in clinical settings.

描述（由申请人提供）：通过皮肤的经皮氧灌注的测量在临床上用作对身体某个区域的血流的测量，并用作伤口愈合潜力的指示性测量。局部血氧测定法也可用于追踪周围血管疾病 (PVD)。目前，用于此目的的唯一临床应用技术是使用基于电极的传感器的经皮氧监测（TCOM），其需要主动加热​​元件来促进氧气通过皮肤扩散。皮下（皮肤表面以下 2 - 3 毫米）组织氧测量可用于确定用于重建手术的血管化游离组织瓣或慢性伤口周围组织的血流量。 我们的团队已经证明，电子顺磁共振 (EPR) 血氧定量法中使用的生物聚合物封装探针在局部应用于感兴趣区域或植入皮下时，可用于此类应用。由于现有仪器的尺寸、重量和空间限制，目前在临床环境中使用 EPR 进行此类测量并不可行。因此，我们建议设计、构建和测试一种用于临床血氧测定应用的新型便携式 EPR 系统。 设想的设备将类似于临床超声设备，具有一个“棒”组件，该组件将与皮肤接触，以便从放置在身体上或植入到表面下方的探头传感器获得血氧测量值。在构建工作原型设备之前，我们将使用计算机建模来确定磁铁和谐振器的最佳布置。然后我们将测试并表征要使用的氧敏感探针。然后，我们将使用原型设备量化大鼠慢性伤口模型中的组织氧合，并继续使用便携式 EPR 装置对人类志愿者进行验证测量，以将这项新技术与现有的基于电极的 TCOM 进行比较。 公共卫生相关性（由申请人提供）：氧气通过皮肤表面的扩散（经皮氧气扩散）可用作许多不同疾病和病症的诊断工具，包括外周血管疾病（PVD）。皮下组织氧水平可用作伤口愈合潜力或组织移植成功的指标。该提案的目的是设计和建造一种新设备，该设备将能够在临床环境中准确、快速地量化经皮氧灌注和皮下（皮肤下 2 - 3 毫米）的氧水平。