Immunological Memory to Covid-19

Covid-19 的免疫记忆

• 批准号: 10632659
• 负责人: Rafi Ahmed
• 金额: $ 210万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-19 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10632659
• 关键词: 2019-nCoV; Antibody Response; Blood specimen; CD8-Positive T-Lymphocytes; COVID-19; COVID-19 long hauler; COVID-19 patient; Cancer Center; Cellular Immunity; Characteristics; Collaborations; Communities; Consent; Development; Diagnosis; Disease; Enrollment; General Population; Hospitalization; Humoral Immunities; Immune response; Immunity; Immunologic Memory; Immunologic Monitoring; Immunologics; Immunotherapeutic agent; Individual; Infection; Long COVID; Mediating; Monitor; Participant; Pathogenicity; Patients; Post-Acute Sequelae of SARS-CoV-2 Infection; SARS coronavirus; SARS-CoV-2 immunity; SARS-CoV-2 infection; Symptoms; T cell response; United States; Universities; Vaccines; adaptive immune response; cohort; global health; insight; longitudinal analysis; member; pandemic coronavirus; pandemic disease

ABSTRACT The SARS-CoV-2 coronavirus pandemic has created the largest global health crisis in almost a century. It is essential to understand the immunological responses that mediate long-term protective immunity to SARS-CoV-21. To assess the durability of humoral and cellular immunity to SARS-CoV-2 in COVID-19 patients we have been collecting longitudinal blood samples from convalescent individuals over the past 18 months. To date we have consented and enrolled 461 individuals that were infected with SARS-CoV-2 into our ongoing study. This cohort includes underrepresented and underserved members of the community. It is important to note that the vast majority (>90%) of the patients in our cohort had mild to moderate disease. This more reflective of COVID-19 infection in the general population. Using this cohort, we are proposing to extend our studies for an additional year to provide an analysis of the magnitude and durability of the antibody response, and CD4 and CD8 T cell responses to SARS-CoV-2 over a three-year period. In addition, 147 patients (32%) in our cohort were diagnosed as COVID-19 “long-haulers” with post- acute sequelae of SARS-CoV-2 (PASC), with symptoms for up to 18 months after infection onset. We will continue to monitor symptoms of PASC for an additional year and determine what features of the adaptive immune response are associated with the development of PASC. This study is a productive ongoing collaboration between the Emory Vaccine Center (PI: Rafi Ahmed) and the Fred Hutchinson Cancer Center (PI: Julie McElrath). Our studies will provide insight into the duration of immunological memory in COVID- 19 convalescent patients, and determine the correlation between PASC and the adaptive immune response.

抽象的 SARS-COV-2冠状病毒大流行造成了近一个世纪以来最大的全球健康危机。它 了解介导长期保护免疫史的免疫学反应至关重要 SARS-COV-21。评估COVID-19中的体液和细胞免疫对SARS-COV-2的耐用性 我们过去一直在康复中收集纵向血液样本 18个月。迄今为止，我们已同意并招募了461名感染SARS-COV-2的人 进入我们正在进行的研究。该队列包括代表性不足和服务不足的成员 社区。重要的是要注意，我们队列中绝大多数（> 90％）的患者温和至 中度疾病。这更反映了普通人群中的共同感染。使用这个队列， 我们建议将研究延长一年，以分析大小和 抗体反应的持续时间，以及三年内CD4和CD8 T细胞对SARS-COV-2的响应 时期。此外，我们队列中有147名患者（32％）被诊断为19.19的“长途猎人” SARS-COV-2（PASC）的急性后遗症，在感染发作后长达18个月内具有符号。我们将 继续监测PASC症状额外的一年，并确定适应性的功能 免疫反应与PASC的发展有关。这项研究是一项持续的富有成效的 Emory疫苗中心（PI：Rafi Ahmed）与Fred Hutchinson癌症中心之间的合作 （PI：Julie McElrath）。我们的研究将洞悉COVID中免疫记忆的持续时间 19例疗养患者，并确定PASC与自适应免疫之间的相关性 回复。