Early joint cranial and brain development from fetal and pediatric imaging

胎儿和儿科成像的早期关节颅骨和大脑发育

• 批准号: 10625390
• 负责人: Natasha Lepore
• 金额: $ 68.79万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625390
• 关键词: 3-Dimensional; Accounting; Address; Affect; Age; Ants; Arizona; Birth; Bone Development; Brain; Brodmann' s area; Cephalic; Child; Childhood; Clinical; Clinical Management; Cognition; Colorado; Craniosynostosis; Data; Data Set; Databases; Deformity; Development; Diagnosis; Diffusion; Disease; Evolution; Face; Fetal Development; Fetal Growth; Fetus; Funding; Future; Goals; Growth; Head; Health; Hospitals; Image; Imaging Device; Imaging Techniques; Impaired cognition; Individual; Infant; Institution; Intracranial Hypertension; Joints; Knowledge; Live Birth; Logistic Regressions; Los Angeles; Magnetic Resonance Imaging; Manuals; Maps; Measures; Methodology; Methods; Modeling; Morphology; Motion; Motor; Multiple Pregnancy; National Institute of Child Health and Human Development; National Institute of Dental and Craniofacial Research; Neurologic; Organ; Patients; Pediatric Hospitals; Physicians; Positioning Attribute; Pregnancy; Research; Research Personnel; Resources; Sampling; Shapes; Standardization; Surgical sutures; System; Testing; Thick; Time; Universities; Variant; Work; X-Ray Computed Tomography; aged; automated segmentation; bone; brain abnormalities; brain morphology; brain shape; brain tissue; brain volume; cortex mapping; cranium; data standards; design; developmental disease; disability; early childhood; fetal; graphical user interface; imaging modality; improved; improved outcome; in utero; in vivo; indexing; model development; morphometry; multidisciplinary; programs; quantitative imaging; sex; success; tool; treatment planning; user-friendly

PROJECT SUMMARY The devastating impacts of early-childhood cranial and skull deformities affect nearly 25% of infants from single pregnancies and 50% of those from multiple pregnancies. If not diagnosed early and treated effectively, these abnormalities can impact brain development, leading to cognitive impairment, elevated intracranial pressure, and motor disabilities. Clinicians’ capacity to effectively diagnose and treat these disorders is hindered by two things: first, a limited understanding of how the cranium and brain normally grow and co- develop; and, second, a dearth of imaging techniques that are sensitive enough to analyze joint cranial and brain development in both healthy and abnormal instances. To address these limitations, a strong, interdisciplinary, collaborative team from Children’s National Hospital, Children’s Hospital Los Angeles, Brown University, University of Colorado and Arizona State University proposes the current R01 aimed at developing the first normative joint model of brain and cranium development before and after birth. This work is f ueled by the team’s robust prior efforts, in which they independently collected large, normative datasets of computed tomography (CT) and magnetic resonance (MR) images of infants and fetuses, and implemented preliminary tools to analyze them as a starting point for new methods to be developed as part of this project . The team’s hypothesis is that the development of regional cortical and cranial morphologies will be strongly associated. It will be tested using the following aims: (1) Develop quantitative imaging tools to model healthy cranial development in infants; (2) Determine the joint development of cranial and cortical shape and thickness in infants; (3) Develop a preliminary model of fetal brain and cranial growth across gestation; and (4) Build and disseminate a user-friendly toolbox for clinicians and researchers. This project will be the first systematic in-vivo study of joint healthy cranial and brain development before and after birth. As such, it will determine typical variations of the cranial shape and their correlations with brain parameters, adjusted for age and sex. The normative models generated here will serve as clinical resources for matched comparisons in individual children with suspected disorders that involve abnormal cranial shapes. Additionally, precise in-vivo quantitative imaging methods for assessing joint cranial and brain shape in inf ants will be developed in this project and will serve as invaluable tools for physicians to better assess, diagnose, and plan treatment for infant cranial deformities in the future.

项目摘要 早期颅骨和头骨畸形的破坏性影响影响了几乎25％的基础设施 多个怀孕的单身怀孕和50％的怀孕。如果没有早点诊断并有效治疗， 这些异常会影响大脑发育，导致认知障碍，颅内升高 压力和运动障碍。临床医生有效诊断和治疗这些疾病的能力是 受到两件事的阻碍：第一，对颅骨和大脑通常如何生长和共同的了解有限 发展;第二，成像技术的死亡足以分析关节颅和 健康和异常实例的大脑发育。为了解决这些限制，一个强大的 跨学科，儿童国家医院，洛杉矶儿童医院的合作团队，布朗 科罗拉多大学和亚利桑那州立大学的大学提议目前的R01旨在开发 出生前后的大脑和颅骨发育的第一个正常关节模型。这项工作是由 团队的强大事先努力，他们独立地收集了大型正常数据集的计算 婴儿和胎儿的层析成像（CT）和磁共振（MR）图像，并实施了初步 将它们作为该项目的一部分开发新方法的起点来分析它们。团队的 假设是，区域皮质和颅形态的发展将密切相关。它 将使用以下目的对：（1）开发定量成像工具来建模健康的颅骨 婴儿的发展； （2）确定颅和皮质形状和厚度的关节发展 婴儿； （3）在妊娠之间发展了胎儿脑和颅颅生长的初步模型； （4）构建和 为临床医生和研究人员传播一个用户友好的工具箱。 该项目将是对关节健康颅和大脑发育的第一个系统内部研究 出生后。因此，它将确定颅骨形状的典型变化及其与大脑的相关性 参数，针对年龄和性别进行调整。这里生成的普通模型将作为临床资源 对于涉及异常颅骨形状的可疑疾病的个别儿童的匹配比较。 此外，精确的体内定量成像方法用于评估INF蚂蚁的关节颅和大脑形状 将在该项目中开发，并将作为医生更好地评估，诊断的宝贵工具 并计划未来婴儿颅骨畸形。