The MesoCase Study: Mesothelioma Case-Control and Rapid Case Ascertainment Study

MesoCase 研究：间皮瘤病例对照和快速病例查明研究

• 批准号: 10625254
• 负责人: Sheiphali Arvind Gandhi
• 金额: $ 5.1万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-28 至 2023-06-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10625254
• 关键词: Academic Medical Centers; Asbestos; Award; Biometry; California; Caring; Case Study; Case/Control Studies; Clinical; Clinical Research; Clinical Trials; Collaborations; Combined Modality Therapy; Country; Data; Data Science; Data Set; Development; Diagnosis; Disease; Early Intervention; Enrollment; Epidemiology; Exposure to; Fellowship; Foundations; Future; Goals; Guidelines; Health; Hour; Impairment; Incidence; Intervention; Intervention Studies; Interview; Link; Lung diseases; Malignant Neoplasms; Maps; Measures; Mesothelioma; Metadata; Modality; National Cancer Program; National Heart, Lung, and Blood Institute; Natural Language Processing; Occupational; Occupational Epidemiology; Occupational Health; Operative Surgical Procedures; Outcome; Patients; Physicians; Population Surveillance; Prevention; Prognosis; Protocols documentation; Proxy; Public Health; Questionnaires; Radiation; Recommendation; Recording of previous events; Registries; Reporting; Research; Research Personnel; Risk; Risk Assessment; Risk Factors; San Francisco; Scientist; Source; Strategic vision; Surveillance Program; System; Techniques; Testing; Time; Training; United States; Universities; Woman; academic preparation; cancer diagnosis; cancer prevention; cancer risk; career; case control; chemotherapy; clinical trial enrollment; epidemiology study; frontier; implementation research; improved; improved outcome; innovation; medical specialties; men; neoplasm registry; novel; prevent; programs; rapid diagnosis; skills; treatment strategy

Project Summary/Abstract Despite steep declines in asbestos usage since the 1970s, the burden of mesothelioma within the United States has not decreased proportionately. The lack of decline is particularly pronounced among women, in whom mesothelioma rates have remained stable for more than three decades. Although the relationship between occupational asbestos exposure and mesothelioma is well-described, our understanding of non- occupational risk factors is limited. Current lags in the cancer registry network enrollment contribute to delayed patient identification, preventing early intervention. Due to delayed patient identification, previous studies primarily relied on unvalidated proxy interviews for risk exposure assessment. In this project, I will collaborate with the California Department of Public Health's Occupational Health Branch (OHB) and the California Cancer Registry (CCR) to create a novel case ascertainment system in order to mitigate these issues. This study's central objective is to use rapid case ascertainment and exposure assessment to elucidate non-occupational asbestos exposures that are associated with the development of mesothelioma. To assess this, I will conduct a case-control study to determine the non-occupational exposures to asbestos utilizing a novel case ascertainment strategy (Aim 1). The secondary objective of this study is to assess the feasibility of creating a rapid mesothelioma case ascertainment program that could facilitate future research and treatment (Aim 2). A rapid cancer-reporting system will create a mechanism for rapid exposure assessments within the public health surveillance system, allowing us to assess cancer risk factors accurately. The proposal is directly responsive to NHLBI's Strategic Vision to "develop and optimize clinical and implementation research to improve health and reduce disease" (Objective 6). Additionally, by developing innovative approaches to integrate multiple forms of data such as natural language processing, exposure history questionnaires, registry metadata, geo-mapping, exposure assessments, and outcome data, our project also fulfills the goal of "leverag[ing] emerging opportunities in data science to open new frontiers in HLBS research" (Objective 7). Through improved public health surveillance and risk assessment, exposures can be mitigated, bolstering cancer prevention efforts. This is particularly important to elucidating the preventable, non-occupational asbestos exposures related to mesothelioma. Furthermore, this award will serve as a foundation for training Dr. Sheiphali Gandhi, a fellow at the University of California San Francisco, to prepare her for her academic research career. This fellowship will provide her with the necessary support to hone her epidemiology and biostatistical skills in order to become an independent physician-scientist studying the epidemiology of occupational and environmental lung diseases.

项目摘要/摘要 尽管自1970年代以来的石棉使用幅度急剧下降，但联合国内部皮质瘤的负担 国家没有按比例减少。女性中缺乏下降尤其明显，在 间皮瘤率一直保持稳定超过三十年。虽然关系 在职业石棉暴露和间皮瘤之间有很好的描述，我们对非 - 职业风险因素有限。癌症注册网络注册中的当前滞后有助于延迟 患者识别，防止早期干预。由于患者的识别延迟，先前的研究 主要依靠未验证的代理访谈进行风险暴露评估。在这个项目中，我将合作 与加利福尼亚公共卫生部的职业健康部（OHB）和加利福尼亚癌症 注册表（CCR）创建一个新颖的案例确定系统，以减轻这些问题。这项研究是 中心目标是使用快速的案例确定和暴露评估来阐明非职业 与间皮瘤发展有关的石棉暴露。为了评估这一点，我将进行 病例对照研究以确定利用新病例的石棉的非占用暴露 确定策略（目标1）。这项研究的次要目的是评估创建一个的可行性 快速间皮瘤病例确定计划，可以促进未来的研究和治疗（AIM 2）。一个 快速癌症报告系统将创建一种机制，用于公共卫生中的快速暴露评估 监视系统，使我们能够准确评估癌症风险因素。该提议直接响应 NHLBI的战略愿景是“开发和优化临床和实施研究，以改善健康和 减少疾病”（目标6）。此外，通过开发创新的方法来整合多种形式 诸如自然语言处理，暴露历史调查表，注册表元数据，地理图， 暴露评估和结果数据，我们的项目还实现了“杠杆”的目标 数据科学的机会开放HLBS研究的新领域”（目标7）。通过改进的公众 健康监视和风险评估，可以减轻暴露，从而加强预防癌症的工作。这 对于阐明可预防的，非占领的石棉暴露尤其重要 间皮瘤。此外，该奖项将成为培训Sheiphali Gandhi博士的基础 加利福尼亚大学旧金山分校为她的学术研究生涯做准备。这个奖学金将 为她提供必要的支持，以磨练她的流行病学和生物统计学技能，以便成为 独立医师科学家研究职业和环境肺部疾病的流行病学。