CATALYTIC PLATFORMS USING AROMATIC IONS AND OTHER CHARGED SPECIES

使用芳香族离子和其他带电物质的催化平台

基本信息

批准号：
10623471
负责人：
Tristan H Lambert
金额：
$ 51.18万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2028-06-30
项目状态：
未结题

项目摘要

Project Summary. Catalysis has long been a potent force for advancing biomedical research by enabling the construction of biologically important molecules with ever-increasing speed, efficiency, and versatility. One of the most potent driving forces for progress in the area of catalysis has been the discovery of new catalytic platforms and concepts. The proposed research program is broadly focused on advancing the area of catalysis through the development of novel catalytic platforms, concepts, and methods. In particular, we have developed two generic catalytic strategies with broad applicability over a wide array of reaction types. In the first program, we have helped to pioneer the area of electrophotocatalysis, which combines the power of light and electrical energy within a single catalyst to promote challenging chemical reactions. Especially, we have introduced trisaminocyclopropenium (TAC) ions as a novel class of electrophotocatalyst; these catalysts have proven to be useful for a number of transformations, including C–H bond functionalizations and olefin derivatizations. The current application seeks to leverage electrophotocatalysis to realize other challenging, unprecedented reactions, especially those requiring very high redox potentials or involving multiple redox events. In the second program, we have pioneered the area of catalytic carbonyl-olefin metathesis, using hydrazine catalysis. This foundational capability enables a wide range of potentially advantageous synthetic methods. The current application seeks to make major advances to this program by designing highly reactive, next-generation catalysts that greatly expand the scope of substrates that can be engaged. We also aim to apply this mode of catalysis to useful new chemical methods, and to develop related catalytic platforms using these general principles. These and other investigations into the use of novel ideas in catalysis will continue to serve as a stimulus for advancements in chemical synthesis.

项目摘要长期以来，催化一直是推动生物医学研究的强大力量。以不断提高的速度、效率和多功能性构建具有生物学意义的重要分子之一。催化领域进步最有力的驱动力是新催化材料的发现拟议的研究计划主要集中于推进催化领域。特别是，我们开发了新型催化平台、概念和方法。两种通用催化策略在多种反应类型中具有广泛的适用性在第一个程序中，我们帮助开拓了电光催化领域，该领域结合了光和电的力量特别是，我们引入了单一催化剂中的能量来促进具有挑战性的化学反应。三氨基环丙烯 (TAC) 离子作为一类新型电光催化剂，已被证明可以可用于许多转化，包括 C-H 键官能化和烯烃衍生化。当前的应用旨在利用电光催化来实现其他具有挑战性的、前所未有的反应，特别是那些需要非常高的氧化还原电位或涉及多个氧化还原事件的反应。第二个项目，我们开创了利用肼催化的催化羰基-烯烃复分解反应领域。这种基础能力使得多种具有潜在优势的合成方法成为可能。应用程序寻求通过高度设计反应式、下一代技术来使该程序取得重大进展我们也致力于应用这种模式的催化剂，大大扩大了可以参与的底物的范围。催化有用的新化学方法，并利用这些通用方法开发相关的催化平台这些和其他关于在催化中使用新想法的研究将继续作为一种方法。刺激化学合成的进步。

项目成果

期刊论文数量（28）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Polycyclic heteroaromatics via hydrazine-catalyzed ring-closing carbonyl-olefin metathesis.

DOI：
10.1039/d1sc06234d
发表时间：
2022-02-23
期刊：
Chemical science
影响因子：
8.4
作者：
Cho EK;Quach PK;Zhang Y;Sim JH;Lambert TH
通讯作者：
Lambert TH

Metal-Free Ring-Opening Metathesis Polymerization with Hydrazonium Initiators.

DOI：
10.1002/anie.202203344
发表时间：
2022-06-13
期刊：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
影响因子：
16.6
作者：
Quach, Phong K.;Hsu, Jesse H.;Keresztes, Ivan;Fors, Brett P.;Lambert, Tristan H.
通讯作者：
Lambert, Tristan H.

Cross-Coupling of Amines via Photocatalytic Denitrogenation of In Situ Generated Diazenes.