Driven exercise and risk for eating disorders: A combined genetic and longitudinal epidemiological investigation

驱动运动和饮食失调的风险：遗传和纵向流行病学联合调查

• 批准号: 10623268
• 负责人: Katherine Schaumberg
• 金额: $ 18.57万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10623268
• 关键词: Accelerometer; Adolescence; Age of Onset; Agitation; Anhedonia; Anorexia Nervosa; Anxiety; Area; Award; Behavior; Biological; Birth; Body Weight; Body fat; Body mass index; Bulimia; Child; Childhood; Chromosome Mapping; Clinical; Collaborations; Complex; Data; Data Analyses; Dependence; Detection; Development; Diagnosis; Disease; Early identification; Eating; Eating Disorders; Environment; Epidemiology; Equation; Etiology; Exercise; Faculty; Future; General Population; Genes; Genetic; Genetic Predisposition to Disease; Genetic Risk; Genomics; Goals; Health behavior; Heritability; Human; Hyperactivity; Individual; Individual Differences; International; Intervention; Investigation; Knowledge; Lead; Link; Longitudinal Studies; Maintenance; Measures; Mental Health; Mental disorders; Mentors; Mentorship; Methods; Modeling; National Institute of Mental Health; Obsessive compulsive behavior; Obsessive-Compulsive Disorder; Onset of illness; Outcome; Parents; Pathology; Pathway interactions; Pattern; Phenotype; Physical activity; Positioning Attribute; Predictive Factor; Prognosis; Psychiatry; Psychologist; Psychology; Psychopathology; Quality of life; Recovery; Regulation; Research; Research Domain Criteria; Research Personnel; Research Project Grants; Research Support; Resources; Rewards; Risk; Risk Factors; Sampling; Science; Shapes; Symptoms; System; Testing; Thinness; Training; Translational Research; Treatment outcome; Universities; Weight maintenance regimen; Wisconsin; Youth; biobehavior; body dissatisfaction; career; career development; clinically relevant; cohort; cooking; data resource; dietary; dieting; disorder risk; early adolescence; emerging adulthood; epidemiologic data; epidemiology study; genetic architecture; genetic epidemiology; genetic information; genome wide association study; improved; member; notch protein; novel; professor; prospective; psychiatric genomics; psychobiology; restraint; risk prediction; risk prediction model; skills; statistics; substance use; suicidal behavior; suicidal risk; symptomatology; therapy development; trait

PROJECT SUMMARY Candidate: I am a clinical psychologist and Assistant Professor in the Department of Psychiatry at the University of Wisconsin (UW). Career Goals: My ultimate goal is to combine my clinical expertise with training in genetic epidemiology and statistical genetics, which will allow me to develop sophisticated risk prediction models for eating- and activity-related risk in psychiatry. Investigations that combine genetic information with detailed epidemiological data will improve understanding of etiology, enhance detection and diagnosis, and lead to novel interventions for psychiatric illness. Career Development: I request support for mentored training to build skills in four areas: (1) genetic and biological risk for health-related behaviors; (2) longitudinal data analysis; (3) genetic epidemiology and statistical genetics; and (4) professional development as a junior faculty member. Research Project: This study leverages existing data resources from the Avon Longitudinal Study of Parents and Children (ALSPAC) and the Psychiatric Genomics Consortium (PGC) along with GWAS summary statistics from several large epidemiological studies. The primary aim of this project will be to map genetic and developmental risk for driven exercise, a common and understudied feature of eating disorders. First, I will identify and characterize physical activity trajectories from late childhood through emerging adulthood in ALSPAC and capture associations between these trajectories and driven exercise and eating disorder risk. Second, I will examine the relationship between driven exercise and eating disorder psychopathology, both in ALSPAC and in the PGC. Finally, I will use genomic structural equation modeling to determine the extent to which driven exercise reflects genetic predispositions to theoretically-linked traits. These results will inform future my independent applications (R01s) that explore unique contributions of genes and environment to predict risk for dysregulated eating and activity patterns in psychiatric illness. Environment: The proposed training and research will occur at UW and includes collaborations with the international power of the PGC and top-notch researchers in the fields of genetic epidemiology, eating disorders, exercise psychology, and statistical genetics. Mentorship: The mentorship team will be led by Dr. Corinne Engelman, whose research focuses on genetic epidemiology of complex human traits. Dr. Cynthia Bulik, co-mentor, is an internationally recognized expert in eating disorder research and co-chair of the eating disorders workgroup of the PGC. Dr. Nadia Micali, co-mentor, has been the lead eating disorder resource on the ALSPAC cohort for the past 20 years. Dr. Dane Cook, collaborator, has expertise in the psychobiology of exercise. Dr. Qiongshi Lu, collaborator, has specialized knowledge in statistical genetics, including methods proposed in this application, and Dr. Cathryn Lewis, collaborator, is a world-renowned expert in statistical genetics. Their combined mentorship will position me to succeed as an independent investigator with a powerful skillset—the ability to apply statistical genetics to clinically-relevant research questions that will elucidate links between health-related behaviors and psychiatric risk.

项目概要 候选人：我是一名临床心理学家，也是大学精神病学系的助理教授 威斯康星大学（UW）的职业目标：我的最终目标是将我的临床专业知识与遗传培训相结合。 流行病学和统计遗传学，这将使我能够开发复杂的风险预测模型 精神病学中与饮食和活动相关的风险，将遗传信息与详细信息相结合。 流行病学数据将提高对病因的了解，加强检测和诊断，并带来新的发现 精神疾病的干预措施：我请求支持指导培训以培养技能。 四个领域：（1）健康相关行为的遗传和生物风险；（3）纵向数据分析； 流行病学和统计遗传学；(4) 作为初级教员研究的专业发展。 项目：本研究利用雅芳父母和儿童纵向研究的现有数据资源 (ALSPAC) 和精神病学基因组学联盟 (PGC) 以及来自多个国家的 GWAS 汇总统计数据 该项目的主要目的是绘制遗传和发育风险图。 驱动性运动是饮食失调的一个常见且尚未得到研究的特征。首先，我将识别并描述其特征。 ASPAC 中从童年晚期到成年初期的身体活动轨迹并捕获 其次，我将研究这些轨迹与驱动运动和饮食失调风险之间的关联。 ASPAC 和 PGC 中驱动性运动与饮食失调精神病理学之间的关系。 最后，我将使用基因组结构方程模型来确定驱动运动反映的程度 这些结果将为我未来的独立应用提供信息。 （R01s）探索基因和环境的独特贡献来预测饮食失调的风险 精神疾病的活动模式 环境：拟议的培训和研究将在华盛顿大学和华盛顿大学进行。 包括与 PGC 的国际力量以及遗传领域的顶尖研究人员的合作 流行病学、饮食失调、运动心理学和统计遗传学：指导团队。 该研究将由 Corinne Engelman 博士领导，他的研究重点是复杂人类特征的遗传流行病学。 共同导师 Cynthia Bulik 博士是国际公认的饮食失调研究专家，也是 PGC 饮食失调工作组的联合导师 Nadia Micali 博士一直是饮食失调的领导者。 合作者 Dane Cook 博士在过去 20 年对 ASPAC 队列进行了研究，拥有这方面的专业知识。 合作者卢琼石博士拥有统计遗传学方面的专业知识， 包括本申请中提出的方法，合作者Cathryn Lewis博士是世界知名专家 他们的指导将使我成为一名成功的独立研究者。 拥有强大的技能——将统计遗传学应用于临床相关研究问题的能力 阐明健康相关行为与精神风险之间的联系。

项目成果

Prospective associations between childhood social communication processes and adolescent eating disorder symptoms in an epidemiological sample.

• DOI: 10.1007/s00787-020-01655-9
• 发表时间: 2021-12
• 期刊: European child & adolescent psychiatry
• 影响因子: 6.4
• 作者: Schaumberg K;Zerwas SC;Bulik CM;Fiorentini C;Micali N
• 通讯作者: Micali N

Prospective associations between childhood neuropsychological profiles and adolescent eating disorders.

• DOI: 10.1002/erv.2721
• 发表时间: 2020-01
• 期刊: European eating disorders review : the journal of the Eating Disorders Association
• 作者: Katherine Schaumberg;Katherine Schaumberg;L. Brosof;E. Lloyd;Z. Yilmaz;C. M. Bulik;C. M. Bulik;S. Zerwas;Nadia Micali;Nadia Micali;Nadia Micali

Registered report: Initial development and validation of the eating disorders safety behavior scale.

• DOI: 10.1002/eat.23479
• 发表时间: 2021-04
• 期刊: The International journal of eating disorders
• 作者: Reilly EE;Bohrer B;Sullivan D;Essayli JH;Farrell NR;Brown TA;Gorrell S;Anderson LM;Cooper M;C Schreyer C;Olesnycky O;Peros O;Schaumberg K
• 通讯作者: Schaumberg K

Prospective Associations Between Driven Exercise and Other Eating Disorder Behaviors in Adolescence: A Longitudinal Cohort Study.

• DOI: 10.1016/j.jadohealth.2021.11.022
• 发表时间: 2022-05
• 期刊: JOURNAL OF ADOLESCENT HEALTH
• 影响因子: 7.6
• 作者: Schaumberg, Katherine E.;Robinson, Lauren;Hochman, Ayelet;Micali, Nadia
• 通讯作者: Micali, Nadia

Predicting eating disorder and anxiety symptoms using disorder-specific and transdiagnostic polygenic scores for anorexia nervosa and obsessive-compulsive disorder.

• DOI: 10.1017/s0033291721005079
• 发表时间: 2023-05
• 期刊: PSYCHOLOGICAL MEDICINE
• 影响因子: 6.9
• 作者: Yilmaz, Zeynep;Schaumberg, Katherine;Halvorsen, Matthew;Goodman, Erica L.;Brosof, Leigh C.;Crowley, James J.;Mathews, Carol A.;Mattheisen, Manuel;Breen, Gerome;Bulik, Cynthia M.;Micali, Nadia;Zerwas, Stephanie C.
• 通讯作者: Zerwas, Stephanie C.