Developing Methods to Estimate Mediation Effects in Adaptive Interventions

开发估计适应性干预中中介效应的方法

基本信息

批准号：
10620857
负责人：
AHNALEE M BRINCKS
金额：
$ 10.91万
依托单位：
MICHIGAN STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-15 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10620857
关键词：
Address Adoption Affect Aftercare Alcohol dependence Analgesics Automobile Driving Behavioral Behavioral Mechanisms Biometry Biostatistical Methods Characteristics Clinical Cocaine Dependence Communicable Diseases Communities Coping Skills Counseling Data Derivation procedure Development Diagnosis Discipline Doctor of Philosophy Dose Drops Drug Addiction Drug usage Epidemiology Evaluation Exhibits Experimental Designs Foundations Funding Future Goals HIV/AIDS Helping to End Addiction Long-term Hepatitis C virus Heroin Hispanic Human Incidence Individual Intermediate Variables Intervention Intervention Trial Journals Knowledge Lead Learning Manuscripts Mediating Mediation Mediator Medicine Mentored Research Scientist Development Award Mentors Methodology Methods Michigan Motivation National Institute of Drug Abuse Natural History Outcome Participant Pathway interactions Patient Care Patients Persons Pharmacotherapy Prevention Property Protocols documentation Randomized Relapse Research Research Design Research Personnel Risk Schools Science Scientist Sequential Multiple Assignment Randomized Trial Statistical Methods Strategic Planning Symptoms Target Populations Testing Time Training Programs Universities Work adaptive intervention addiction behavior change care systems career development college coping design drug abuse prevention drug use behavior effective intervention evidence base experience experimental study improved innovation interest motivational intervention novel novel strategies opioid abuse prevention opioid use disorder preventive intervention professor programs reduced substance use simulation theories tool treatment choice treatment program treatment research

项目摘要

PROJECT SUMMARY The proposed K01 Mentored Research Scientist Development Award will prepare Ahnalee Brincks, Ph.D. to lead the development of novel quantitative methods needed to understand the mechanisms through which person-focused adaptive interventions affect drug use and addiction (DUA), including heroin and other opioid use disorders (OUD). Dr. Brincks, Assistant Professor of Biostatistics at the Michigan State University College of Human Medicine, will benefit from the NIDA-funded establishment of MSU's Drug Dependence Epidemiology Training Program and National Hispanic Science Network Mentoring Program, continued with university support under the direction of an experienced NIDA PI, Dr. Jim Anthony, who serves as here lead K01 sponsor. Person-focused adaptive interventions (AIs) are used by clinicians make adaptations to treatment based on participant characteristics that are observed before and after treatment starts. As promising new approaches for clinical and preventive interventions in DUA and OUD, AIs give practitioners evidence-based tools to adjust an intervention to fit each patient's needs as these needs evolve, to deliver the most effective intervention at the ideal time and in the optimal dose. Current statistical approaches exist to evaluate whether AIs work and for whom AIs are effective. However, there are no statistical tools for understanding how the AIs work at the level of the person's experience, via supra-molecular mechanisms and mediational pathways investigated in clinical and prevention researchcontexts. New mediation methods are needed to improve AIs via greater understanding of intervening pathways. Identification of intervening pathways can lead to discover of new intervention targets to be challenged or confirmed in subsequent field-driving AI trials of OUD and DUA interventions. K01 support will strengthen Dr. Brincks' career development. In addition to studying OUD/DUA natural history and clinical course, diagnosis and patient care services, she also will learn 1) epidemiology as applied to DUA, their determinants and complications, defined to encompass HIV/AIDS, HCV, and other infectious diseases, 2) current DUA interventions and their hypothesized mediators, 3) experimental designs used to build adaptive interventions (e.g., Sequential Multiple Assignment Randomized Trials), and 4) state-of-the-science causal approaches to mediational pathways in NIDA research. In her K01 research, her primary aim is development of new quantitative methods to better understand mechanisms through which AIs reduce OUD and other DUA. A second aim involves applying these methods to evaluate mediation hypotheses in AI trial data. She will launch an independent program focused on OUD/DUA mediational pathways, extending current AI approaches beyond clinical intervention evaluations to focus on reducing OUD/DUA incidence rates in communities, schools, and target populations. As such, this work should have far-reaching implications for NIDA strategic goals.

项目概要拟议的 K01 指导研究科学家发展奖将为 Ahnalee Brincks 博士做好准备。到领导开发新的定量方法，以了解其机制以人为本的适应性干预措施影响药物使用和成瘾（DUA），包括海洛因和其他阿片类药物使用障碍（OUD）。 Brincks 博士，密歇根州立大学学院生物统计学助理教授人类医学系，将受益于 NIDA 资助建立的密歇根州立大学药物依赖性流行病学培训计划和国家西班牙裔科学网络指导计划，在大学支持下继续进行在经验丰富的 NIDA PI Jim Anthony 博士的指导下，他担任 K01 的首席赞助商。临床医生使用以人为本的适应性干预措施 (AI)，根据情况调整治疗在治疗开始之前和之后观察到的参与者特征。作为有前途的新方法 DUA 和 OUD 的临床和预防干预措施，AI 为从业者提供基于证据的工具来调整随着患者需求的变化，进行干预以满足每个患者的需求，从而在患者需要时提供最有效的干预理想的时间和最佳的剂量。当前的统计方法可以评估人工智能是否有效以及是否有效人工智能对哪些人有效。然而，没有统计工具可以帮助我们了解人工智能如何在该层面上工作。通过临床研究的超分子机制和中介途径来了解人的经历和预防研究背景。需要新的中介方法通过加深理解来改进人工智能的干预途径。识别干预途径可以发现新的干预目标在随后的 OUD 和 DUA 干预的现场驱动人工智能试验中受到挑战或证实。 K01 的支持将加强 Brincks 博士的职业发展。除了学习 OUD/DUA 自然历史以及临床课程、诊断和患者护理服务，她还将学习 1) 应用于 DUA 的流行病学，其决定因素和并发症，定义为包括 HIV/AIDS、HCV 和其他传染病，2) 当前的 DUA 干预措施及其假设的中介因素，3）用于构建适应性的实验设计干预措施（例如序贯多重分配随机试验），以及 4) 最先进的因果关系 NIDA 研究中的中介途径方法。在她的 K01 研究中，她的主要目标是开发新的定量方法可以更好地理解人工智能减少 OUD 和其他 DUA 的机制。一个第二个目标涉及应用这些方法来评估人工智能试验数据中的中介假设。她将推出一个专注于 OUD/DUA 中介途径的独立项目，将当前的人工智能方法扩展到其他领域临床干预评估重点关注降低社区、学校和社区的 OUD/DUA 发生率目标人群。因此，这项工作应该对 NIDA 的战略目标产生深远的影响。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Familias Unidas Prevents Youth Internalizing Symptoms: a Baseline Target Moderated Mediation (BTMM) Study.

DOI：
10.1007/s11121-021-01247-2
发表时间：
2023-03
期刊：
Prevention science : the official journal of the Society for Prevention Research
影响因子：
0
作者：
Brincks A;Perrino T;Howe G;Estrada Y;Robles N;Prado G
通讯作者：
Prado G

Preventing alcohol use among Hispanic adolescents through a family-based intervention: The role of parent alcohol misuse.

通过基于家庭的干预措施防止西班牙裔青少年饮酒：父母滥用酒精的作用。

DOI：
10.1037/fam0001038
发表时间：
2023
期刊：
Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)
影响因子：
0
作者：
Brincks,Ahnalee;Perrino,Tatiana;Estrada,Yannine;Prado,Guillermo
通讯作者：
Prado,Guillermo

Reducing Screen-Based Sedentary Behavior Among Overweight and Obese Hispanic Adolescents Through a Family-Based Intervention.

通过基于家庭的干预措施减少超重和肥胖西班牙裔青少年基于屏幕的久坐行为。

DOI：
10.1123/jpah.2022-0050
发表时间：
2022
期刊：
Journal of physical activity & health
影响因子：
3.1
作者：
Perrino,Tatiana;Brincks,AhnaleeM;Estrada,Yannine;Messiah,SarahE;Prado,Guillermo
通讯作者：
Prado,Guillermo

Mechanisms by Which the Fun for Wellness Intervention May Promote Subjective Well-Being in Adults with Obesity: a Reanalysis Using Baseline Target Moderation.

DOI：
10.1007/s11121-021-01274-z
发表时间：
2023-03
期刊：
PREVENTION SCIENCE
影响因子：
3.5
作者：
Myers, Nicholas D;Prilleltensky, Isaac;McMahon, Adam;Brincks, Ahnalee M;Lee, Seungmin;Prilleltensky, Ora;Pfeiffer, Karin A;Bateman, Andre G
通讯作者：
Bateman, Andre G

Secondary Analysis to Inform the Development of Adaptive Preventive Interventions.